دانلود رایگان مقاله لاتین پیش بینی واکنش در چالش تخم مرغ آب پز از سایت الزویر
عنوان فارسی مقاله:
توسعه یک مدل پیش بینی واکنش شدید در چالش های تخم مرغ آب پز
عنوان انگلیسی مقاله:
Development of a prediction model of severe reaction in boiled egg challenges
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Oral food challenges (OFC) have been performed for the definitive diagnosis of a food allergy and more frequently, for the discernment of tolerance to the allergen.1 In addition to these conventional purposes, OFCs are performed to determine the threshold dose of food allergens for individuals beginning oral immunotherapy (OIT) or to determine the threshold of minimal avoidance. More severe reactions tend to be provoked in these OFC settings. Sampson's grade stratification2 is commonly used for an assessment of the severity of allergic reaction provoked in an OFC, and the Japanese Guideline for Food Allergy 2014 adopted it with minor modifications.3 This classification mostly aims to evaluate the severity of a reaction to decide the indications for therapy including intramuscular epinephrine injection. For that purpose, severity is judged based on the highest grade of symptoms, even if multi-organ reactions are provoked. On the other hand, an evaluation of multi-organ symptoms can be an important severity marker in some purposes because the number of symptomatic organs involved in an allergic reaction affects the outcome of achieving tolerance afterward.4,5 For this purpose, we have developed an original scoring system named Anaphylaxis Scoring Aichi (ASCA) for a quantitative evaluation of multi-organ reactions provoked in OFCs.6 ASCA lists and sorts allergic symptoms according to five organ systems (respiratory, skin-mucosal, gastrointestinal, psycho-neurological, and cardiovascular). In the gastrointestinal symptoms, the degree of abdominal pain was expressed as face scale (Supplementary Fig. 1). Each symptom was given an organ system score of 0e60 points in accordance to the severity. The gradient of the points was set for the purpose that the sum of plural mild points does not exceed one severe organ system point. The organ system score of 40 points almost corresponds to grade 4 of Sampson's grade2 (Table 1). The total score (TS) was defined as the sum of 5 organ system scores (maximum 240 points) based on the highest organ system score observed throughout a course of OFC. We have already validated the TS to be correlated to Sampson's grade6 (Fig. 1). Several studies have tried to predict the result of OFCs and their severity of outcome. Although a probability curve of specific Immunoglobulin E (sIgE) provides useful information for predicting a positive challenge7 and a severe reaction,8 another report suggested a limitation in its predictive accuracy.9 Component-resolved diagnostics for wheat (u-5 gliadin)10 and peanut (Ara h 2)11 provided a promising prediction for the positive result of an OFC, but failed to predict the threshold dose and the severity of symptoms. Clinical backgrounds should also be considered to predict the outcome of an OFC including the severity of the provoked reactions.4,12,13 A recent article suggested that a complex model incorporating both test results and a clinical history had a better predictive ability compared to simply relying on the sIgE and skin prick test (SPT) either alone or in combination with one another.4 For the purpose of identifying a severe allergic reaction, a complex model is thought to be a better predictor.12
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کلمات کلیدی:
Food Allergy - Page 182 - Google Books Result https://books.google.com/books?isbn=1437719929 Wesley Burks, John M. James, Philippe Eigenmann - 2011 - HEALTH & FITNESS skin test size and food-specific serum antibody level to egg white may help clinicians ... reported by Shreffler et al.39 to correlate with less severe milk-allergic reactions. ... visit he had an egg challenge under observation with hard-boiled egg. Pediatric Allergy, Asthma and Immunology https://books.google.com/books?isbn=3540333959 Arnaldo Cantani - 2008 - Medical Parents should be informed about possible severe reactions and give their written ... Procedure of Open Challenges with CM, Egg, Wheat, and Fish We follow the ... given, that is 100 ml of CM or half-boiled egg, or 100 g of bread or 80 g of fish. The Inside Tract: Your Good Gut Guide to Great Digestive Health https://books.google.com/books?isbn=1609614275 Gerard E. Mullin, Kathie Madonna Swift - 2011 - Health & Fitness If you suspect that you may have a severe reaction, you should discuss this with ... will test and you can record the results of each food challenge (i.e., Pass or Fail). ... To test eggs, use a hard-boiled egg as your test food, rather than egg salad. Spectrum Reading Workbook, Grade 7 - Page 8 - Google Books Result https://books.google.com/books?isbn=1483812200 Spectrum - 2014 - Juvenile Nonfiction Georgia is allergic to peanuts, and Angela is allergic to eggs. ... “I don't mean to cause problems, but when I eat eggs, I have serious physical reactions ... Spectrum Reading Grade 7 8 “So, this will be a challenge,” Jessica says thoughtfully, “but we can ... Or hard-boiled eggs,” Rachel declares and giggles at the thought of ... Spectrum Reading Workbook, Grade 7 - Page 8 - Google Books Result https://books.google.com/books?isbn=1483814149 2014 - Juvenile Nonfiction Georgia is allergic to peanuts, and Angela is allergic to eggs. ... “I don't mean to cause problems, but when I eat eggs, I have serious physical reactions ... Spectrum Reading Grade 7 8 “So, this will be a challenge,” Jessica says thoughtfully, “but we can ... Or hard-boiled eggs,” Rachel declares and giggles at the thought of ...
