دانلود رایگان مقاله لاتین نشانگر پروتئینی قابل هدف یابی محل زخم از سایت الزویر
عنوان فارسی مقاله:
قرارگیری اکتین بر روی آسیب بافت یک نشانگر پروتئینی قابل هدف یابی محل خاص زخم است
عنوان انگلیسی مقاله:
Actin exposure upon tissue injury is a targetable wound site-specific protein marker
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
There are a milieu of biochemical and physiological events at a wound site due to structural changes resulting from cell lysis or tissue rupture and the associated displacement of intracellular or extracellular proteins from their natural locations. Studies in model organisms, such as zebrafish, demonstrated that myocellular injury leads to expression of specific markers, such as Xinactin-binding repeat-containing proteins (Xirp), with a potential role in cytoskeletal reorganization and muscle regeneration [13]. Other studies have shown that injury of the blood vessel wall and surrounding extracellular matrix by mechanical rupture or heat results in irreversible unfolding of collagen from its native state [22], generating signals for induction of arteriolar vasodilation and increase in blood flow to the injured area [10]. In addition, necrotic cells resulting from tissue injury can be detected by the immune system through recognition of damage-associated molecular patterns (DAMPs) by dendritic cell receptors, leading to inflammatory response and tissue repair [2,16]. Identification of targetable wound-specific markers would represent a viable mechanism for the detection and specific delivery of biologically important materials to wound surfaces, such as therapeutic or hemostatic payloads. Additionally, identification of such targets might be advantageous in minimizing administered dosages, improve the availability due to increased local delivery, and avoid potential deleterious interactions with nearby healthy tissue. Wound targeting would also enable binding to non-compressible, asymmetrically exposed internal organ areas as a result of penetrating or surgical wounds, irrespective of geometry and location. To date, however, biological epitopes that are specific to injured tissue sites remain largely unknown. The objective of this study was to identify protein markers that become rapidly exposed in wounded animal tissues and might be
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کلمات کلیدی:
Factors Affecting Wound Healing - NCBI - NIH https://www.ncbi.nlm.nih.gov › NCBI › Literature › PubMed Central (PMC) by S Guo - 2010 - Cited by 1286 - Related articles A better understanding of the influence of these factors on repair may lead to therapeutics ... Keywords: wound healing, inflammation, proliferation, tissue remodeling ... at a specific time, and continue for a specific duration at an optimal intensity .... collagen formation, and the formation of granulation tissue at the site of injury. Methods and Compositions For Wound Treatment - Leidos, Inc. www.freepatentsonline.com/y2017/0089922.html Mar 30, 2017 - A method for identifying a wound target, wherein the wound target is an exposed ... exposed protein, peptide motif or epitope becomes exposed upon wounding, ... The method of claim 2, wherein the tissue is in an organ selected from the ... for identifying proteins and peptide motifs exposed in wound sites, ... Civetta, Taylor, and Kirby's Manual of Critical Care https://books.google.com/books?isbn=0781769159 Andrea Gabrielli, A. Joseph Layon, Mihae Yu - 2011 - Medical Current flowing through tissue is related to the voltage drop across the ... blood, and nerves; skin has an intermediate resistance. s Contact wounds on the hands ... Electricity can travel 2 to 3 cm/10,000 volts and may travel 10 feet or more to its target. ... sThe diagnosis of inhalation injury is based on several sitespecific and ... John Dresios, Ph.D. | LinkedIn https://www.linkedin.com/in/john-dresios-ph-d-74588446 San Diego, California - Chief Scientist, Technical Fellow at Leidos - Leidos View John Dresios, Ph.D.'s professional profile on LinkedIn. LinkedIn is ... Actin Exposure upon Tissue Injury is a Targetable Wound Site-Specific Protein Marker. Innovative Research Innovative Grade US Origin Sprague Dawley Rat ... https://www.innov-research.com/innovative-grade-us-origin-sprague-dawley-rat-kidn... May 24, 2016 - Written by jessica on June 9, 2016. Posted in ... Actin Exposure upon Tissue Injury is a Targetable Wound Site-Specific Protein Marker. Soft-tissue injury: Pathophysiology, evaluation, and classification https://www2.aofoundation.org/.../04_Sj9CPykssy0xPLMnMz0vMAfGjzOKN_A0M3... Open fractures and fractures with severe, closed soft-tissue damage are ... injuries, contamination and infection of the wound have a negative effect on the .... soft-tissue density, or entrapped air around and/or distal to the fracture site. ... Type IIIB: There is extensive soft-tissue loss with periosteal stripping and bone exposure.
