دانلود رایگان مقاله لاتین مسمومیت کبدی ناشی از استامینوفن از سایت الزویر
عنوان فارسی مقاله:
بیومارکرهای بالقوه جدید مسمومیت کبدی ناشی از استامینوفن
عنوان انگلیسی مقاله:
New potential biomarkers of acetaminophen-induced hepatotoxicity
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Acetaminophen (N-acetyl-p-aminophenol, APAP, paracetamol) 12 is one of the most commonly used antipyretic and analgesic drugs. 13 Taking it in therapeutic doses, is harmless, however, APAP 14 overdosing may cause hepatotoxicity. Many pharmaceutical products contain APAP and are available without any prescription. 15 Their easy availability results in constantly-increasing rate of APAP 16 poisoning cases. For this reason, the safety of APAP is still widely 17 discussed. 18 APAP has similar properties (analgesic and antipyretic proper- 19 ties) to nonsteroidal anti-inflammatory drugs (NSAIDs), but it does 20 not possess any anti-inflammatory activity. Applied in recom- 21 mended doses, APAP does not cause gastrointestinal side effects, 22 which is common for NSAIDs. After ingestion, about 90% of APAP is 23 metabolized in the liver, where it is conjugated with glucuronic acid (50–60%) and sulfuric acid (25–35%). A small amount of this 26 drug (3%) binds to cysteine. The products ofthese conjugations are 27 pharmacologically inactive and are eliminated by the urinary 28 system. About 5% of APAP is eliminated by the kidneys in an 29 unchanged form. Another 5% of APAP undergoes N-hydroxylation 30 by cytochrome P450 enzymes, producing a toxic metabolite i.e. 31 N-acetyl-p-benzoquinone imine (NAPQI, N-acetylimidoquinone). 32 In therapeutic APAP doses, reactive NAPQI is sufficiently 33 deactivated by conjugation with sulfhydryl groups of glutathione 34 (GSH). The final product of APAP metabolism is mercapturic acid, 35 which is eliminated with urine. The situation changes if APAP is 36 overdosed. Metabolic reactions cause hepatic GSH depletion and 37 NAPQI binds to various hepatocyte macromolecules such as 38 proteins, lipids and DNA. It leads to metabolic disturbances and 39 cell death. N-acetylcysteine (NAC) restores GSH resources, 40 therefore administration of NAC plays an essential role in medical 41 care of patients with APAP overdose. However, NAC is fully 42 hepatoprotective only when distributed within 8 h after APAP 43 ingestion [1].
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کلمات کلیدی:
Translational biomarkers of acetaminophen-induced acute liver injury https://www.ncbi.nlm.nih.gov › NCBI › Literature › PubMed Central (PMC) by RD Beger - 2015 - Cited by 17 - Related articles May 17, 2015 - Acetaminophen (APAP) is a commonly used analgesic drug that can cause liver injury, liver necrosis and liver failure. APAP-induced liver injury ... Mechanistic Biomarkers in Acetaminophen-induced Hepatotoxicity ... https://www.ncbi.nlm.nih.gov › NCBI › Literature › PubMed Central (PMC) by MR McGill - 2014 - Cited by 36 - Related articles May 16, 2014 - Introduction. Drug hepatotoxicity is a major clinical issue. Acetaminophen (APAP) overdose is especially common. Serum biomarkers used to ... Highlight report: biomarkers of acetaminophen-induced liver injury ... link.springer.com/article/10.1007/s00204-015-1629-z by HM Bolt - 2015 - Related articles Nov 3, 2015 - A comprehensive review about translational biomarkers of acetaminophen-induced acute liver damage has been published in our journal ... [PDF]New potential biomarkers of acetaminophen-induced hepatotoxicity iranarze.ir/wp-content/uploads/2016/10/E117.pdf New potential biomarkers of acetaminophen-induced hepatotoxicity. 4. Katarzyna Siemionow. Q1 a,*, Joanna Teul a, Paweł Dra˛gowski a, Jerzy Pałka b, ... Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update www.jcthnet.com/images/fulltext/v4/131_JCTH-D-15-00052.pdf by E Yoon - 2016 - Cited by 18 - Related articles Reported cases of APAP-induced hepatotoxicity first .... Yoon E. et al: Acetaminophen-induced liver toxicity ..... Serum biomarkers of APAP-induced liver injury. Identification of Early Biomarkers during Acetaminophen-Induced ... journals.plos.org/plosone/article?id=10.1371/journal.pone.0045521 by R Gautam - 2012 - Cited by 11 - Related articles Sep 19, 2012 - Acetaminophen is a widely prescribed drug used to relieve pain and fever; however, it is a leading cause of drug-induced liver injury and a ... Identification of Novel Translational Urinary Biomarkers for... - PLOS journals.plos.org/plosone/article?id=10.1371/journal.pone.0049524 by RPL van Swelm - 2012 - Cited by 17 - Related articles Nov 14, 2012 - (2012) Identification of Novel Translational Urinary Biomarkers for Acetaminophen-Induced Acute Liver Injury Using Proteomic Profiling in Mice. Single Cell Sequencing and Systems Immunology https://books.google.com/books?isbn=9401797536 Xiangdong Wang - 2015 - Medical Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and ... H. Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute ...
