دانلود رایگان مقاله لاتین ماکروفاژ محیطی از سایت الزویر
عنوان فارسی مقاله:
تحریک MΦ2 فنوتیپ مانند ضد التهابی در ماکروفاژهای محیطی با نمک زیاد
عنوان انگلیسی مقاله:
High salt induces anti-inflammatory MΦ2-like phenotype in peripheral macrophages
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Macrophages have an important role in innate immunity mediated inflammation and host defense [1]. Transformation of different phenotypes of macrophages regulate the initiation, development, and cessation of inflammatory diseases [2]. While, classically activated macrophages (MΦ1) comprise immune effector cells with an acute inflammatory and phagocytic phenotype [3]. Conversely, alternatively activated MΦ2-macrophages are anti-inflammatory and aid in inhibition of immune-damage and immune-tolerance [4]. A variety of external signals, such as, microbes, damaged tissue and infiltrating lymphocytes have been shown to play an important role in the preferential MΦ1 versus MΦ2 macrophage activation. In the tumor micro-environment, among the innate and adaptive immune cells recruited to the tumor site, macrophages are particularly abundant and are present at all stages of tumor progression [5]. Clinical studies and experimental mouse models indicate that these macrophages generally play an anti-inflammatory and pro-tumoral role [6]. Speci- fically, the tumor associated macrophages (TAM) have an MΦ2 phenotype with reduced antigen presentation capacity, thereby possibly leading to evasion of cancer immuno-elimination [7]. Further recent evidence suggests that high levels of TAM are often correlated with tumor metastasis and poor prognosis [5]. The high sodium content of mammary adenocarcinomas has been shown to be significantly higher than the normal lactating mammary epithelium [8]. Interestingly, recent studies by Jantsch et al. [9], suggest that skin infiltrating macrophages undergo phenotype changes [9]. However, the dermal micro-environment is known to have high sodium tonicity. These dermal resident macrophages have been indicated to sense the interstitial electrolyte composition and subsequently upregulate various transcription factor possibly resulting in their activation and phenotype changes [10]. Similarly high salt is considered to influence the macrophage activation in lung [11] and bone-marrow derived mouse macrophages[11]. However, currently there is limited evidence to demonstrate the direct role of high salt on macrophage activation. Peripheral blood mononuclear cells (PBMC) derive from myelomonocytic precursors in the bone marrow. Myelomonocytes circulate in the blood for approximately 72 h and then migrate to tissues to become macrophages [12]. The pattern of in vitro modulation of cell surface antigens in PBMC in many respects resembles the pattern seen in tissue macrophages [12]. As salt changes have been noted in cancer development [13], and these sites have higher frequency of alternatively activated MΦ2- macrophages, we hypothesized that high salt directly induces MΦ2-macrophage activation. In our current study, using in vitro macrophage cultures we directly determined the role of high sodium chloride concentration on macrophage phenotype changes.
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کلمات کلیدی:
[PDF]High salt induces anti-inflammatory MΦ2-like phenotype in peripheral ... iranarze.ir/wp-content/uploads/2016/10/E1214.pdf Taken together, these data suggest that high salt extracellular environment induces an anti- inflammatory MΦ2-like macrophage phenotype with poor phagocytic ... AACR 2016: Abstracts 2697-5293: - Google Books Result https://books.google.com/books?id=gijVCwAAQBAJ American Association for Cancer Research (AACR) - 2016 - Medical Innate Immune System, Myeloid Cells, and Tumorigenesis #3228 High salt induces anti-inflammatory MΦ2-like phenotype in peripheral macrophages. Amara S[au] - PubMed Result jneurosci.org/lookup/external-ref?access_num=Amara%20S&link_type... 1: Amara S, Tiriveedhi V. Inflammatory role of high salt level in tumor ... Tiriveedhi V. High salt induces anti-inflammatory MΦ2-like phenotype in peripheral ... Article metrics for: Macrophage biology in development, homeostasis ... www.nature.com/nature/journal/v496/n7446/nature12034/metrics/citations?page=23 Apr 25, 2013 - High salt primes a specific activation state of macrophages, M(Na) ... High salt induces anti-inflammatory MΦ2-like phenotype in peripheral ... Article metrics for: Macrophage plasticity and interaction with ... - Nature www.nature.com › Home › archive › issue › Review › Article › Article metrics Sep 20, 2010 - Simplexide Induces CD1d-Dependent Cytokine and Chemokine Production from ... High salt induces anti-inflammatory MΦ2-like phenotype in ... [PDF]CytoSelect™ 96-Well Phagocytosis Assay (Red ... - Cell Biolabs, Inc. https://www.cellbiolabs.com/sites/default/files/CBA-220-phagocytosis-assay.pdf by P Manual - Related articles 122001): One 20 µL tube of Rabbit Anti-Sheep RBC, IgG. 2. 10X Wash .... High salt induces anti-inflammatory MΦ2-like phenotype in peripheral macrophages. Article: High salt induces anti-inflammatory MΦ2-like phenotype in ... https://manuscriptpro.com/.../High-salt-induces-anti-inflammatory-MΦ2-like-phenoty... Author Suneetha Amara (Department of Medicine, Mercy Hospital, St Louis, MO.), Author Margaret Whalen (Department of Chemistry, Tennessee State ...
