دانلود رایگان مقاله لاتین غلظت سرمی پروتئین از سایت الزویر
عنوان فارسی مقاله:
غلظت سرمی پروتئین در پرتوافکنی در دوز پایین به بدن سالم و دچار سو تغذیه
عنوان انگلیسی مقاله:
Serum protein concentration in low-dose total body irradiation of normal and malnourished rats
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Among the radiotherapeutics' modalities, total body irradiation (TBI) is used as treatment for certain hematological, oncological and immunological diseases, being an important part of the treatment in bone marrow and stem cell transplants. For patients at low risk of cell engraftment rejection, non-myeloablative conditioning regime with single fraction low-dose TBI (2–3 Gy) is an effective treatment option, alone or combined with chemotherapy. However, the incidence of complication induced by TBI is elevated, presenting as common problems such as renal toxicity, cataracts and functional reduction of the pituitary gland (Onal et al., 2012). In parallel, another aggravating factor of complications that arises from the application of TBI is the general health of the patients which, in most cases, present weight loss due to the simultaneous occurrence of malnutrition (Oliveira, 2007; Ollenschlager et al., 1991). From animal studies, it has been observed that malnutrition interferes directly on growth and body development, especially on body mass, triggering a sequence of adaptation mechanisms, especially on the musculoskeletal system, such as changing the fiber type (Paiva et al., 2012; Toscano et al., 2008, 2010). The plasma concentration of total protein is reported as an important and reliable parameter for malnutrition assessment (Nwokocha et al., 2012a; Santos et al., 2004), although clinically, the isolated dosage of total protein has little value, since a change in one of their fractions (globulins or albumin) can be compensated by changing the other one, where 6.4 g/dL is accepted as the minimum threshold (Labtest, 2014). The albumin level is one of the several clinical parameters of general health as well as the most widely used biochemical indicator of malnutrition. There is a strong correlation between lower-than-normal albumin levels and the incidence of morbidity and mortality in hospitalized patients. Serum values lower than 3.5 g/dL are considered indicative of malnutrition, chronic liver diseases, nephrotic syndrome and of state of protein catabolism (Doweiko and Nompleggi, 1991; Fontoura et al., 2006; Vannucchi et al., 1996). In this context, taking into account the importance in the follow-up of pediatric patients after TBI treatment, the aim of this study was to evaluate the long-term effects of low-dose total body irradiation on plasma concentration of total protein and albumin using prematurely and undernourished rats as animal model.
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کلمات کلیدی:
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