دانلود رایگان مقاله لاتین عفونت توکسوپلاسما از سایت الزویر
عنوان فارسی مقاله:
القای مولد اینترلوکین 10 سلول های B تنظیمی به دنبال عفونت توکسوپلاسما گوندی برای تشکیل کیست مهم است
عنوان انگلیسی مقاله:
Induction of IL-10-producing regulatory B cells following Toxoplasma gondii infection is important to the cyst formation
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Toxoplasma gondii is an intracellular protozoan parasite with a worldwide distribution that infects a variety of warm-blooded mammals and causes toxoplasmosis, one of the most common chronic parasitic infections in humans: approximately one-third of the world population carries T. gondii [1]. Toxoplasmosis is usually clinically asymptomatic in healthy individuals but it can lead to severe complications in pregnant women and immunocompromised patients. The life cycle of T. gondii includes two asexual stages: rapidly dividing tachyzoites are found in the spleen and non-lymphoid tissues in the first week of infection and define the acute phase, whereas slowly dividing bradyzoites, residing mainly inside tissue cysts in the brain, appear around the second week and mark the beginning of the chronic phase [2]. Acute infection is characterized by tachyzoite proliferation and is known to cause lymphadenitis and congenital infection of fetuses [3]. During chronic infection, the parasite forms cysts, preferentially in the brain, and this phase is characterized by the balance between host immune responses and the parasite immune evasion. Parasites employ various strategies to evade host immune responses that normally thwart infection. The establishment and maintenance of chronic infection involves a balance between host immunity and parasite evasion of the immune response [4]. Although immune evasion supposedly evolved to favor parasite establishment within the host, some particular immune-escaping strategies might, quite paradoxically, be beneficial for the host [5]. Regulatory B cells (Bregs), regulatory T cells (Tregs), and alternatively activated macrophages have been identified as key components of the immune regulatory network functioning during helminth infections [6–8]. These immunoregulatory cells expand during parasite infection and may promote the development of chronic infection and parasite survival, as well as influence unrelated immune-driven pathology such as allergy and autoimmune diseases [7,9]. B cells typically function as antibody-producing cells but they are also involved in other immune functions including cytokine and chemokine secretion and antigen presentation. In addition, IL- 10-producing B cells have been shown to participate in the induction of immune tolerance and the suppression of inflammation [9–11]. The IL-10-producing subset of Bregs was first demonstrated to play a critical role in limiting disease severity in autoimmune conditions [6]. In recent studies, it has been found that these Bregs are also significantly induced during parasite infection [6,12–14].
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کلمات کلیدی:
Induction and Differentiation of IL-10–Producing Regulatory B Cells ... www.jimmunol.org/content/early/2017/01/12/jimmunol.1600218 by Z Bankó - 2017 Jan 15, 2017 - IL-10–producing B cells represent a major subset of regulatory B cells (Bregs) ... Regulatory B cell induction by Toxoplasma gondii infection ... What do we know about the role of regulatory B cells - Taylor & Francis ... www.tandfonline.com/doi/pdf/10.1080/20477724.2017.1308902?needAccess=true of infection of two major parasitic diseases, malaria and leishmaniasis? Roberta Reis ..... IL-10-producing CD1dhiCD5+ Breg cells isolated from B. microti-infected ..... of IL-10– producing regulatory B cells following Toxoplasma gondii infection ... What do we know about the role of regulatory B cells (Breg) during the ... www.tandfonline.com/doi/full/10.1080/20477724.2017.1308902?ai=1xir0&mi... Mar 29, 2017 - FO B cells are a major component of adaptive immune response and ..... to immune system-related diseases, infectious and/or cancerous, they ...... Induction of IL-10–producing regulatory B cells following Toxoplasma gondii ... Regulatory T cells and infection: a dangerous necessity : Article ... www.nature.com › Journal home › Archive › Review by Y Belkaid - 2007 - Cited by 669 - Related articles Failure to establish or restore homeostatic conditions during or following the onset of ... IL-10-producing T regulatory 1 (T R1) cells can be induced by dendritic cells ..... by its crucial role during acute infection of mice with Toxoplasma gondii. ... be produced by numerous cell types, including macrophages, DCs, B cells and ... Microbial Host-interaction: Tolerance Versus Allergy https://books.google.com/books?isbn=3805591675 Per Brandtzaeg, Erika Isolauri, Susan L. Prescott - 2009 - Medical Once allergen-specific IgE is bound to basophils or tissue mast cells, a new ... Furthermore, lack of exposure to certain orofecal infections, such as hepatitis A, Toxoplasma gondii or Helicobacter ... More recently, the importance of regulatory T cells and the production of immunosuppressive cytokines, such as IL-10 and TGF- ... The Diverse Role of NK Cells in Immunity to Toxoplasma gondii Infection journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005396 by JP Gigley - 2016 - Cited by 2 - Related articles Feb 25, 2016 - CD8 T cell interferon (IFN)γ is the major mechanism of protection [3,4]; ... NK cells produce IL-10 and regulate innate responses by .... following chemical hapten exposure in mice lacking T cells or B cells, ... Suzuki Y, Remington JS (1988) Dual regulation of resistance against Toxoplasma gondii infection by ...
