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عنوان فارسی مقاله:
مهار چسبندگی ماکروفاژ توسط SPC برای عروق سلولهای عضله صاف
عنوان انگلیسی مقاله:
Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Mononuclear cell adhesion to endothelial cells and their subsequent infiltration into the vascular wall is an important initiating event in the development of atherosclerosis and in blood vessel re-occlusion (restenosis) following angioplasty [1,2]. Adhesion is typically stimulated by cytokines such as tumour necrosis factora (TNF) released from inflammatory cells and vascular smooth muscle cells (SMC) [3]. These cytokines lead to an upregulation of adhesion proteins in endothelial cells, in particular vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1), which facilitate monocyte adhesion [4]. Following adhesion to endothelial cells, tissue infiltration of monocytes and their subsequent differentiation to macrophages lead to a local inflammatory response which drives the development of vascular disease [5]. This consists of changes in the vascular SMC phenotype from a quiescent to a more proliferative and migratory cell type [6]. While research has focussed on the mechanisms of monocyte/macrophage adhesion to endothelial cells, relatively little attention has been paid to interaction of monocyte/macrophage with vascular SMC. Evidence now indicates that monocyte/macrophage adhesion to vascular SMC is likely to be involved in the initiation of vascular disease [7,8]. It is clear that macrophages and vascular SMC are in direct contact in atherosclerotic plaque regions of human blood vessels [9]. In addition, proliferating neointimal vascular SMC, resulting from vascular injury and endothelial denudation, display an increased binding of monocytes [10]. This evidence demonstrates that monocytes/- macrophages can not only adhere to vascular SMC, but that this interaction may also be an integral part of vascular disease pathogenesis. Sphingolipids are a class of lipid mediators which are naturally occurring in blood and may regulate cell–cell interactions [11]. The most studied sphingolipid, sphingosine 1-phosphate (S1P) is stored in erythrocytes and is an important component of lipoproteins [12,13]. S1P actions are mediated by a specific class of G-proteincoupled 7-transmembrane receptors consisting of 5 isoforms S1P1–5 [14]. These receptors activate a repertoire of intracellular signalling pathways such as intracellular calcium release and activation of mitogen-activated protein kinases. Most cell types, including vascular SMC, express at least 2 isoforms of the S1P receptor [15,16]. Recent evidence now suggests that another sphingolipid, sphingosylphosphorylcholine (SPC), can also have important effects on the cardiovascular system [17]. SPC, similar to S1P, is naturally occurring. The source(s) of SPC production, release and metabolism in vivo are not clear although the SPC concentration is raised in serum compared to plasma suggesting release from platelets and SPC (similar to S1P) is also a constituent of lipoproteins [18,19]. Although a high affinity receptor for SPC has not been identified, SPC can act as a low affinity agonist at S1P receptors [20]. In addition, recent evidence has indicated that SPC signal transduction to intracellular pathways can also occur via lipid raft membrane domains [21,22]. These lipid raft-dependent effects have been observed in several cell types including vascular smooth muscle and could potentially be receptor-independent [23]. Such effects could involve direct interaction of SPC with these membrane lipid domains. In vascular SMC, we and others have shown that SPC has several actions including vasoconstriction and proliferation [24,25] although whether these are receptordependent or receptor-independent is not known. The effects of SPC on monocyte/macrophage adhesion to vascular SMC have not previously been investigated.
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کلمات کلیدی:
macrophage heparanase inhibition: Topics by Science.gov https://www.science.gov/topicpages/m/macrophage+heparanase+inhibition Macrophages activation by heparanase is mediated by TLR-2 and TLR-4 and ...... Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular ... Professor Graeme Nixon | Staff Profile | The University of Aberdeen https://www.abdn.ac.uk › About Us › Colleges and Institutes Results 1 - 25 of 32 - 'Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells'. Biochemical Pharmacology, vol 115, pp. High-Density Lipoproteins: Structure, Metabolism, Function and ... https://books.google.com/books?isbn=1118158660 Anatol Kontush, M. John Chapman - 2011 - Science Sphingosylphosphorylcholine can also act on S1P3 receptors, resulting in ... PON1 may degrade oxidized lipids and thereby inhibit ensuing macrophage ... The regulation of angiogenesis by tissue cell-macrophage interactions: https://books.google.com/books?isbn=2889193179 Michal Amit Rahat, Bernhard Hemmerlein, Vijaya Iragavarapu-Charyulu - 2014 - Physiology macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas. ... activator in sphingosylphosphorylcholine-induced angiogenesis. ... (2011). HRG inhibits tumor growth and metastasis by inducing macrophage ... Sphingosylphosphorylcholine and Lysophosphatidylcholine Are ... www.jbc.org/content/276/44/41325.abstract by K Zhu - 2001 - Cited by 239 - Related articles Nov 2, 2001 - Sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC) are .... Protein Kinase Activation, and Adenylate Cyclase Inhibition .... Loss of G2A promotes macrophage accumulation in atherosclerotic lesions of low ... Sphingosylphosphorylcholine and lysosulfatide have inverse ... - Agris agris.fao.org/agris-search/search.do;jsessionid...locale... Consistently, SPC promoted, while LSF inhibited, monocyte adhesion to fibronectin, ... differentiation into macrophages through regulating the Raf/MEK/ERK and ... Christian A. M. Wilson - FastRef | FastFormat https://fastformat.co/b/fastref?q=author:'Christian%20A.%20M.%20Wilson' [Artigo] Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells · Christiane Wirrig; Jenny S. McKean; Heather M. Wilson; ...
