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عنوان فارسی مقاله:
سلولهای دندریتیک - رزیگلیتازون به واسطه بهبود آرتریت - کلاژن القا شده در موش
عنوان انگلیسی مقاله:
Rosiglitazone-mediated dendritic cells ameliorate collagen-induced arthritis in mice
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Rheumatoid arthritis (RA) is a systemic, chronic autoimmune disease that primarily targets the synovial membranes [1]. RA is currently treated with immunosuppressive drugs and/or biologic agents such as methotrexate and infliximab. However, these therapeutic agents cause blanket immunosuppression, which increases the risk of infectious disease and cancer [2,3]. Therefore, new therapeutic approaches should aim to suppress inflammation. The mouse model of type II collagen-induced arthritis (CIA) has proven to be a useful model of RA, since the characteristic cellular immune response is similar to that in human RA [4]. The main pathological features of CIA include proliferative synovitis accompanied by polymorphonuclear and mononuclear cell infiltration, pannus formation, cartilage degradation, bone erosion, and fibrosis. Dendritic cells (DCs) are potent stimulators of adaptive immunity; however, mounting evidence suggests that DCs also establish and maintain immunological tolerance [5]. Tolerogenic DCs (tDCs) play an important role in inducing peripheral tolerance via specific mechanisms, including activation of regulatory T (Treg) cells, suppression of effector T cells, and negative modulation of Th1/Th2 immune responses [6–8]. Indeed, a promising new immunotherapeutic strategy aimed at attenuating pathogenic T cell responses is based on autologous tDCs [9]. The use of tDCs for immunotherapy is an attractive approach to treating autoimmune diseases in an antigen (Ag)-specific manner; this may avoid the need for steroids, which are associated with systemic immunosuppression and adverse effects. Peroxisome proliferator-activated receptor-gamma (PPAR-c) belongs to the nuclear hormone receptor superfamily. PPAR-c is highly expressed in adipose tissue, where it plays a role in regulating adipocyte differentiation, fatty acid storage, and glucose metabolism; it is also a target for anti-diabetic drugs [10]. A recent study showed that PPAR-c protein was expressed by antigen presenting cells, monocytes, and macrophages, and plays a fundamental role in immune responses [11]. Indeed, synthetic PPAR-c agonists suppress the production of inflammatory cytokines by these cells [12,13].
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کلمات کلیدی:
External Article Page - Faculty of 1000 f1000.com/prime/ext/726373407 May 18, 2016 - Rosiglitazone-mediated dendritic cells ameliorate collagen-induced ... DC (Rosi-DC) therapy suppressed arthritis in a collagen-induced ... [PDF]Curriculum Vitae - BRIC www.ibric.org/myboard/view.php?Board=hbs_author&filename...pdf... Mar 31, 2017 - (2016) Rosiglitazone-mediated dendritic cells ameliorate collagen-induced arthritis in mice. Biochemical pharmacology 115: 85-93. Jung NC ... Mesenchymal Stem Cells Regulate the Innate and Adaptive Immune ... pubmedcentralcanada.ca/pmcc/articles/PMC5101398/ by RA Contreras - 2016 - Related articles Oct 26, 2016 - Indeed, MSCs inhibit the activation of dendritic cells (DCs), ...... Rosiglitazone-mediated dendritic cells ameliorate collagen-induced arthritis in ... Rosiglitazone | Sigma-Aldrich www.sigmaaldrich.com/catalog/search?interface...Rosiglitazone&N... Search results for Rosiglitazone at Sigma-Aldrich. ... Rosiglitazone-mediated dendritic cells ameliorate collagen-induced arthritis in mice. Sei-Hee Byun et. al sei | Sigma-Aldrich www.sigmaaldrich.com/catalog/search?interface=All&term=sei&N... Role of cancer stem cell in radioresistant head and neck cancer. ... Rosiglitazone-mediated dendritic cells ameliorate collagen-induced arthritis in mice. Sei-Hee ... Hyodae Seo - Publications - Academic Tree https://academictree.org/physics/publications.php?pid=294295 Effects of Angelicae dahuricae Radix on 2, 4-Dinitrochlorobenzene-Induced .... Rosiglitazone-mediated dendritic cells ameliorate collagen-induced arthritis in ...
