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عنوان فارسی مقاله:
درگیری ریز RNA-200C در گسترش سرطان معده با سرکوب مستقیم p27Kip1
عنوان انگلیسی مقاله:
MicroRNA-200c is involved in proliferation of gastric cancer by directly repressing p27Kip1
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Gastric cancer is one of the most common and aggressive forms in China [1]. Patients with gastric cancer are often given a poor prognosis due to the difficulty of early diagnosis with highly growth and high rate of recurrence [2,3]. It has been suggested that the abnormal expression of check point genes can always be found in tumorgenesis, including TP53, P27Kip1, P21Cip2, P16Ink1 and C-Myc [4–8]. P27Kip1, also known as Cyclin-dependent kinase inhibitor 1B, binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1 stage [9]. It is always thought the inhibitor of cell cycle with a tumor suppressor [10,11]. In cancers it is often inactivated via impaired synthesis, accelerated degradation, or mislocalization [12]. We previously reported that FoxM1, the main positive regulator of cell cycle, can regulate gastric cancer cells proliferation and senescence through inhibition of P27Kip1 [13,14]. These observations support that P27Kip1 is strongly negatively correlated with gastric carcinogenesis. It is important to better understand the regulation of P27Kip1 expression in tumorgenesis for anti-cancer therapy. Currently, microRNAs (miRNAs) has been thought one of the most important regulators in tumorgeneis [15–18]. MiRNAs are the small non- translated RNA molecules with approximately 18–24 nucleotides in length. Every miRNA can directly bind to the complementary sequence on the 3′-untranslated region (3′-UTR) of many possible target mRNAs, which thus regulates the genes expression by post-transcriptional gene silencing, producing sequence specific mRNA cleavage, or translational repression [19,20]. MiRNAs can be the tumor suppressors or oncogenes which are determined by the functions of their target genes [21,22]. There are only a few research on the miRNAs regulation on P27Kip1 expression in tumorgenesis, including miR-221/222 [23,24]. We still need more evidence on specific miRNA regulation on P27Kip1 and its function in gastric carcinoma. In this study, we demonstrated that miR-200c is an oncogene in gastric carcinoma which can directly inhibit the expression of P27Kip1 in vivo and in vitro. To our knowledge, this is the first time to explore the relationship between miR-200c and P27Kip1 in gastric carcinoma. We propose that antagomiRNAs of miR-200c might be the potential for an anti-cancer therapy by reactivation of P27Kip1.
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کلمات کلیدی:
MicroRNA‐212 inhibits proliferation of gastric cancer by directly ... onlinelibrary.wiley.com/doi/10.1002/jcb.24613/pdf by Z Jiping - 2013 - Cited by 31 - Related articles MicroRNA‐212 Inhibits Proliferation of Gastric Cancer by. Directly Repressing Retinoblastoma Binding Protein 2. Zeng Jiping,. 1,2. Fang Ming,. 1,3. MicroRNA-200c is involved in proliferation of gastric cancer by directly ... www.sciencedirect.com/science/article/pii/S2405580816301819 by Y Wang - 2016 - Related articles miR-200c is involved in the proliferation of gastric cancer cell lines. ... MiR-200c could enhance the colony formation of cells by repressing P27Kip1 expression. MicroRNA-212 inhibits proliferation of gastric cancer by directly ... https://www.researchgate.net/.../241694359_MicroRNA-212_inhibits_proliferation_of_... MicroRNA-212 inhibits proliferation of gastric cancer by directly repressing retinoblastoma binding protein 2 on ResearchGate, the professional network for ... Histological and Pathological Assessment of miR-204 and SOX4 ... https://www.hindawi.com/journals/bmri/2017/6894675/ by X Yuan - 2017 - Related articles Nov 29, 2016 - miRNAs directly interact with the mRNA 3′ untranslated regions (3′UTR) of their ... and tumor suppressing genes and usually negatively regulate them [11, 12]. .... miR-204 Suppressed Proliferation of Gastric Cancer Cells. miR-125b Suppresses Proliferation and Invasion by Targeting MCL1 ... https://www.hindawi.com/journals/bmri/2015/365273/ by S Wu - 2015 - Cited by 7 - Related articles May 18, 2015 - miR-125b elicits these responses by directly targeting MCL1 (myeloid cell ... To date, the role of miR-125b in gastric cancer has been undefined. ... of miR-125b dramatically repressed proliferation, induced apoptosis in vitro, ... MiR-196a Is Upregulated in Gastric Cancer and Promotes Cell ... mct.aacrjournals.org/content/11/4/842.full.pdf colony formation of gastric cancer cells, and ectopic miR-196a expression significantly ... mediated repression in cell proliferation was reverted by exogenous miR-196a expression. ... directly targeting p27kip1 (also known as CDKN1B). The. Cancer Gene Therapy - MicroRNAs in tumorigenesis, metastasis ... www.nature.com › Journal home › Archive › Review May 22, 2015 - Moreover, the overexpression of miR-21 in gastric cancer is directly ... Futhermore, p27 (kip1)-mediated repression in cell proliferation was ... Regulation of TRIM24 by miR-511 modulates cell proliferation in ... https://jeccr.biomedcentral.com/articles/10.1186/s13046-017-0489-1 by Z Fang - 2017 Jan 23, 2017 - Dual-luciferase reporter assay further verified TRIM24 is a direct target of miR-511. ... tumor-suppressive role of miR-511 in GC by suppressing TRIM24, suggesting that this ... miR-511 TRIM24 Cell proliferation Gastric cancer ...
