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عنوان فارسی مقاله:
SOX2 سرکوب تحرک سرطان اوروتلیال با ارتقا حالت S100A14
عنوان انگلیسی مقاله:
SOX2 suppresses the mobility of urothelial carcinoma by promoting the expression of S100A14
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Post-transcriptional regulation mechanisms, including alternative splicing, mRNA stability, and translation modulation, play a major role in creating transcriptome and proteome complexity. Mechanistically, it is essential to select correct RNA transcripts for regulation [1,2]. The trans-acting guide-RNA-carrying protein complexes and RNA binding proteins are responsible to achieve the target specificity by recognizing the cis-sequence elements on the RNA transcripts. While the guide RNA-protein complexes, which are typified by microRNA-loaded RNA-induced silencing complex (RISC), achieve sequence-specific recognition through complementary annealing of the guide RNA [3], RNA binding proteins bind to the target RNA sequences through the RNA binding domains [4]. It was estimated that the human genome encodes hundreds of RNA binding proteins, but only limited numbers of the RNA binding protein repertoire have been extensively studied [5–7]. Given the important role of post-transcriptional regulation in cellular functions, it is necessary to advance our understanding on the functions of RNA binding proteins. RNA binding proteins binds to the target RNA transcripts through sequence-specific RNA-binding domains [8]. Although most of RNA binding proteins possess RNA-specific interaction domains, such as the RNA recognition motif (RRM) and hnRNP K homologous domain (KH domain) [8–10], some DNA binding proteins were shown to exhibit RNA binding capabilities. One of such versatile nucleic acid binding motifs is the zinc-finger DNAbinding domain [11,12]. The most notable example dual function transcription factor is Wilm’s tumor 1 (WT1), the master regulator for the development of the urinary and reproductive systems in mammals [13–15]. WT1 interacts with splicing factor and RNA binding protein, including U2AF65, WTAP, and RBM4. As the result of its RNA binding activity, WT1 performs diverse post-transcriptional activities, including 3′ splice site selection in the nucleus as well as mRNP localization and translation regulation in the cytoplasm [16–18]. Recently, p53, which is also a zinc-finger protein, was implicated in microRNA biogenesis by facilitating the recognition of the stem-loop structure on the primary microRNA [19], further supporting the zinc-finger domain can be used as DNA binding as well as post-transcriptional RNA recognition.
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کلمات کلیدی:
SOX2 suppresses the mobility of urothelial carcinoma by promoting ... zoodyab.ir/.../115627-sox2-suppresses-the-mobility-of-urothelial-c... Translate this page ... suggesting that SOX2 suppresses cell growth and mobility through promoting the expression of S100A14. Together, our experimental evidence indicates that ... Down-regulation of LncRNA TUG1 enhances radiosensitivity in ... https://ro-journal.biomedcentral.com/articles/10.1186/s13014-017-0802-3 by H Jiang - 2017 Apr 4, 2017 - lncRNA TUG1 HMGB1 Bladder cancer Radiosensitivity ... High mobility group box 1 protein (HMGB1), a chromosome-binding protein, .... treatment promotes the TUG1 and HMGB1 expression in bladder cancer cell lines. Fig. Granzyme B is expressed in urothelial carcinoma and promotes ... onlinelibrary.wiley.com/doi/10.1002/ijc.25135/pdf by D D'Eliseo - 2010 - Cited by 20 - Related articles In our study, we investigated GrB and Pf expression in bladder cancer cell lines and in ... This data provides the first evidence for a role of GrB in promoting cancer cell invasion. ..... from neighboring cells and increase their mobility and matrix. Prognostic impact of the expression of ALDH1 and SOX2 in urothelial ... www.nature.com › Journal home › Archive › Original Articles Aug 17, 2012 - Upper urinary tract urothelial cell carcinomas are uncommon and account for .... high mobility group box 2 (SOX2) expression status and (c) combined .... NANOG promotes cancer stem cell characteristics and prostate cancer ... PubMed Result - NCBI www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid... ... shRNA constructs inhibits the bioactivity of urothelial carcinoma cell lines via the ... Y. Reduced high-mobility group box 1 expression induced by RNA interference ... 7: Chen Y, Lin C, Liu Y, Jiang Y. HMGB1 promotes HCC progression partly ... Down-regulation of HMGB1 expression by shRNA constructs inhibits ... https://www.ncbi.nlm.nih.gov › NCBI › Literature › PubMed Central (PMC) by Z Huang - 2015 - Cited by 4 - Related articles Aug 4, 2015 - The high mobility group box 1 (HMGB1), which is a highly conserved and ... Our data suggest that HMGB1 promotes the malignant biological ... Bladder urothelial carcinomas (BUCs) represent nearly 90% of BCs that arise ...
