دانلود رایگان مقاله لاتین سرطان آندومتر از سایت الزویر
عنوان فارسی مقاله:
بیان ژن های سرکوبگر تومور مربوط به چرخه سلولی در بیماران مبتلا به سرطان آندومتر
عنوان انگلیسی مقاله:
Expression of tumor suppressor genes related to the cell cycle in endometrial cancer patients
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
The increased incidence of endometrial cancer in the last 11 decade has placed it as the most common gynecological 12 malignancy in developed countries [1]. This trend is becoming 13 more marked in Poland [2]. The well-acknowledged dualistic 14 carcinogenesis model based on clinicopathological characteristics 15 has led to two types of endometrial cancer being distinguished 16 [3]. Approximately 75–80% of uterus malignancies are estrogen- 17 dependent type I endometrial cancer with endometrioid 18 morphology (EEC, endometrioid endometrial cancer) including 19 adenocarcinomas. Endometrioid cancer arises from complex 20 atypical endometrial hyperplasia and is pathogenetically associated with unopposed estrogenic stimulation. It occurs in 21 peri- and postmenopausal women and has a good prognosis 22 [4]. Type II cancer is characterized by non-endometrioid histology 23 and non-estrogen dependency. It develops from atrophic endome- 24 trium and carries a poor prognosis [3,4]. The existence of two 25 different cancer types has been confirmed by molecular biology 26 based studies [5]. 27 Tumor suppressor genes (TSGs) are the guardian genes that 28 prevent oncogenic transformation. These genes play a critical role 29 in controlling the cell cycle checkpoints that are needed for the 30 normal outcome of proliferation and differentiation. Hence, TSGs 31 can prevent accumulating mutations and protect the cell from 32 acquiring cancer phenotype by inducing apoptosis [6,7]. The role of 33 tumor suppressor genes in estrogen dependent endometrial cancer 34 is important and has an impact on new therapies. Furthermore, 35 gene expression changes in TSGs (p53, PTEN) are considered to be 36 poor prognostic factors [8,9]. 37 The aim of this study was to analyze the expression profile of 38 tumor suppressor genes related to the cell cycle in patients with endometrial adenocarcinoma across histological differentiation 41 and to identify transcripts differentiating endometrium into 42 various pathomorphological grades.
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کلمات کلیدی:
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