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عنوان فارسی مقاله:
درد اندومتریوز و طب سوزنی
عنوان انگلیسی مقاله:
Endometriosis pain and acupuncture
سال انتشار : 2015
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مقدمه انگلیسی مقاله:
1. Introduction
Endometriosis is a multifactorial condition that can result in long-lasting visceral pelvic pain and infertility [24,35,76,77,12]. The condition is affecting approximately 10–15% of women in reproductive age [82]. The endometrial tissue is innervated by nerve fibres that may interact in the local oestrogen dependent inflammatory processes [74,7]leading to angiogenesis, adhesions, fibrosis, scarring [27] and ultimately in perceived pain [49]. Nociceptors are found in most visceral tissues including the uterus and cervix Tong et al. [85]. There is increasing evidence that endometriosis elicits changes in the population of uterine nociceptors. For example, women with endometriosis have many small unmyelinated nerve fibres in the functional layer of their endometrium. These nerve fibres are probably nociceptors, invading peritoneal endometriotic lesions [11], and are not present in women without endometriosis [71]. This suggests that there is abnormal sprouting of nociceptors in the endometrium and in peritoneal endometriotic lesions in women with endometriosis. Such nerve sprouting is likely caused by increased levels of NGF and GDNF [4,72]. Probably many of the nociceptors in the endometrium have the properties of ‘silent nociceptors’ [26]. These nociceptors are normally silent without responding to mechanical (pressure or distension) or thermal stimuli. When the surrounding tissue is ∗ Corresponding author. E-mail addresses: Irene.Lund@ki.se, irene.lund@quicknet.se (I. Lund). inflamed however, they become sensitized i.e., change from being exclusively noxious stimulus detectors to detectors also of innocuous inputs [15]. This peripheral sensitization represents a form of stimulus evoked functional plasticity of the nociceptor. Sensitizing agents (PGE2, kinins, amines, growth factors, chemokines and cytokines) reduce the threshold level of activation and increase the responsiveness of the terminal by binding to specific receptors expressed on the membrane of the nociceptor terminal. [53,56,57,67]. The exact function and interrelationship of the different second messengers in nociceptor signalling remains to be established as it for the moment remains unclear what determines the use of the varying signalling pathways in nociceptive neurons especially as most of them are polymodal e.g., respond to multiple kinds of stimuli. Peripheral sensitization results in hyperalgesia i.e. increased sensitivity in the receptive field of the nociceptive neuron (primary hyperalgesia). A common aspect of endometriosis pain is spontaneous pain (stimulus-independent pain). This pain may arise from signal molecules continuously released from the cysts that act on nociceptor peripheral terminals to either produce a depolarization sufficient to initiate action potentials or a reduction in threshold levels such that innocuous stimulus (as for example pulsation of blood vessels) now activate what had been high-threshold thermoand mechanonociceptors. This spontaneous pain is transmitted in C-fibres.
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کلمات کلیدی:
Top stories New Endometriosis Pain Treatments Are Focusing on Oxidized Cholesterol Endometriosis News Today · 17 hours ago Two million women in the UK are affected by endometriosis, here is all you need to know about the painful condition The Sun · 2 days ago Groundbreaking discovery uncovers key to understanding endometriosis - Vanderhoof News Vanderhoof Omineca Express · 17 hours ago More for Endometriosis pain Back pain? Chest pain? Leg Pain? - Endometriosis specialist nezhat.org/back-pain-chest-pain-leg-pain/ However, did you know that many women with endometriosis also report lower back pain, leg & hip pain, acid reflux, chronic fatigue, and many other symptoms ... Do you have Endo? | Endometriosis Research Center https://www.endocenter.org/do-you-have-endo/ With endometriosis, the disease occurs on the pelvic structures (and sometimes beyond), causing severe pain, bowel, bladder or other organ dysfunction, ... This Is What Endometriosis Really Feels Like | Prevention www.prevention.com/health/what-endometriosis-really-feels-like Dec 30, 2015 - Endometriosis is more than just a painful period. Learn what it's really like. What Is Endometriosis? Symptoms (Pain), Stages, Diet & Surgery www.medicinenet.com › ... › women's health a-z list › endometriosis index Oct 7, 2016 - Endometriosis is the abnormal growth of endometrial cells outside the uterus. The most common symptom is pelvic pain. Endometriosis is more ... Endometriosis, pelvic pain, heavy bleeding - Women Living Naturally www.womenlivingnaturally.com/articlepage.php?id=196 What are the symptoms of endometriosis? A common symptom of endometriosis is pain, mostly in the abdomen, lower back, and pelvic areas. The amount of ... Searches related to Endometriosis pain endometriosis pain all the time endometriosis pain relief what does endometriosis pain feel like symptoms of endometriosis cancer all symptoms of endometriosis how is endometriosis diagnosed do i have endometriosis quiz pictures of endometriosis
