دانلود رایگان مقاله لاتین بیماری کلانژیوکارسینومای داخل کبدی از سایت الزویر
عنوان فارسی مقاله:
عوامل کلینیکی مرتبط با بقای بیماران مبتلا به کلانژیوکارسینومای داخل کبدی
عنوان انگلیسی مقاله:
Clinical factors associated with the survival of patients with intrahepatic cholangiocarcinoma
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Cholangiocarcinoma is a relatively uncommon but lethal cancer of the biliary epithelium; it accounts for 10e25% of all hepatobiliary malignancies [1,2]. Various risk factors for cholangiocarcinoma and a number of different diagnostic/ therapeutic modalities have been examined in clinical scenarios in order to understand the factors affecting survival of patients with this disease. To date a satisfactory solution to this global problem has not been found. Attempts to identify the factors affecting patient survival have been impeded by: (1) a lack of disease-specific symptoms in early stages; (2) surgical resection not being an appropriate treatment option; and (3) high rates of tumor recurrence following surgical resection [3e9]. According to anatomic locations, cholangiocarcinoma is classified into three subtypes, including: (1) intrahepatic cholangiocarcinoma (ICC); (2) perihilar cholangiocarcinoma (PCC); and (3) distal cholangiocarcinoma (DCC) [8]. Results from a large, single-centered study found that ICC accounted for less than 10% of cases of cholangiocarcinoma; PCC for 50%; and DCC for approximately 40% [10]. In contrast to PCC and DCC, the incidence of ICC saw a steady increase of 22% between 1979 and 2004 due to advances in diagnostic techniques in Western countries [6,11,12]. This increase in incidence was accompanied by a 39% increase in mortality [12]. ICC has overtaken hepatocellular carcinoma (HCC) as the leading cause of death in the UK since the mid-1990s [13]. Previous studies describe the distinction between ICC and extrahepatic cholangiocarcinoma [14], but potential risk factors remain unknown [2]. Therefore, establishing the prognostic factors and locations of tumor involvement such as peripheral or main bile ducts or extrahepatic metastasis may decide the patient’s prognosis prior to implementation of intervention options. To attain the greatest benefit in clinical scenarios, two points were assessed in this study. First the predictive factors affecting survival over the study period (including 3- and 6-month results) were investigated. These factors were then used to further elucidate the benefits of various modalities, which included curative, palliative, and no treatment, in ICC patients. We expect this study to provide valuable information which can be used in clinical settings.
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کلمات کلیدی:
Clinical factors associated with the survival of patients with ... www.sciencedirect.com/science/article/pii/S2351979715000237 by CF Ting - 2016 - Related articles Apr 23, 2015 - ICC is a cholangiocarcinoma subtype affecting the intrahepatic biliary tract and classification of tumor involvement is made according to the American Joint Committee on Cancer (AJCC) TNM (tumor, node, and metastases) Staging System [15]. Treatment and Prognosis for Patients With Intrahepatic ... jamanetwork.com/journals/jamasurgery/fullarticle/1857649 by MN Mavros - 2014 - Cited by 85 - Related articles Apr 9, 2014 - Surgical approach for long-term survival of patients with intrahepatic cholangiocarcinoma: a multi-institutional analysis of 434 patients. Surgical Approach for Long-term Survival of Patients With Intrahepatic ... jamanetwork.com/journals/jamasurgery/fullarticle/1351953 by D Ribero - 2012 - Cited by 89 - Related articles Aug 20, 2012 - Choi SB, Kim KS, Choi JY, et al. The prognosis and survival outcome of intrahepatic cholangiocarcinoma following surgical resection: ... Strategies to improve survival of patients with intrahepatic ... onlinelibrary.wiley.com/doi/10.1002/hep.28994/full by R Gupta - 2017 Feb 3, 2017 - Strategies to improve survival of patients with intrahepatic cholangiocarcinoma undergoing liver transplantation ... Diagnosis and Treatment of Cholangiocarcinoma - The Oncologist theoncologist.alphamedpress.org/content/9/1/43.full by CD Anderson - 2004 - Cited by 289 - Related articles The prognosis for unresectable patients is poor, and palliative measures should ... Patients with intrahepatic cholangiocarcinomas rarely present with jaundice; ... Ablative Radiotherapy Doses Lead to a Substantial Prolongation of ... ascopubs.org/doi/abs/10.1200/jco.2015.61.3778 by R Tao - 2015 - Cited by 28 - Related articles Ablative Radiotherapy Doses Lead to a Substantial Prolongation of Survival in Patients With Inoperable Intrahepatic Cholangiocarcinoma: A Retrospective Dose ... An update on the management of intrahepatic cholangiocarcinoma ... tgc.amegroups.com/article/view/9029/9642 by KW Ma - 2016 - Related articles Margin width tends to influence survival of patients with solitary tumour and node ... Keywords: Intrahepatic cholangiocarcinoma (ICC); liver cancer; evidence; ...
