دانلود رایگان مقاله لاتین بهبود آگونیست از سایت الزویر
عنوان فارسی مقاله:
بهبود آگونیست های گیرنده CRF2 انتخابی حالت توسعه یافته اضطراب و افسردگی در طول درمان نیکوتین مزمن در موش
عنوان انگلیسی مقاله:
Selective CRF2 receptor agonists ameliorate the anxiety- and depressionlike state developed during chronic nicotine treatment and consequent acute withdrawal in mice
سال انتشار : 2016
برای دانلود رایگان مقاله بهبود آگونیست اینجا کلیک نمایید.
مقدمه انگلیسی مقاله:
1. Introduction
The urocortins (UCN 1, UCN 2 and UCN 3) are corticotropinreleasing factor (CRF)-related peptides with similar amino acidic structure, but different pharmacological profile. In contrast to CRF that binds preferentially to CRF receptor 1, UCN 1 attaches equipotently to both CRF receptors (Vale et al., 1981; Vaughan et al., 1995), whereas UCN 2 and UCN 3 bind selectively to CRF2 receptor, therefore these are considered selective agonists of the CRF2 receptor (Lewis et al., 2001; Reyes et al., 2001). Central administration of CRF and UCN 1 induces activation of the hypothalamic-pituitary-adrenal (HPA) axis, anxiety-like and depression-like behavior (Bale and Vale, 2004; Vale et al., 1981; Vaughan et al., 1995), while central administration of UCN 2 and UCN 3 produces anxiolytic and antidepressant actions (Tanaka and Telegdy, 2008; Telegdy and Adamik, 2013; Valdez et al., 2002, 2003). Accordingly, activation of the CRF1 receptor, expressed predominantly in the cerebral cortex, the cerebellum and the anterior pituitary, is believed to initiate the endocrine, autonomic and behavioral reactions to stress (Bale and Vale, 2004; Reul and Holsboer, 2002; Van Pett et al., 2000), while activation of the CRF2 receptor, limited centrally to subcortical regions (amygdala, hippocampus, hypothalamus), is thought to terminate these stress responses (Bale and Vale, 2004; Reul and Holsboer, 2002; Van Pett et al., 2000). Actually, the role of CRF2 receptor in the regulation of the HPA axis is still under debate (Fekete and Zorrilla, 2007; Suda et al., 2004), because studies in mice and rats led to contradictory results (Bale et al., 2000, 2002; Jamieson et al., 2006; Maruyama et al., 2007; Pelleymounter et al., 2004). Besides the regulation of the stress responses, CRF and the urocortins have been implicated in drug addiction (Bruijnzeel and Gold, 2005; Sarnyai et al., 2001). For instance nicotine, the addictive substance of tobacco, can activate the HPA axis, just like any other stressor may do, although its impact on behavior depends on the dose and the time of administration. On the one hand, acute administration of low doses of nicotine promotes anxiolytic and antidepressant behavior (Andreasen and Redrobe, 2009; Balerio et al., 2005; Varani and Balerio, 2012). On the other hand, acute or chronic administration of higher doses of nicotine provokes anxiety and depression (Bura et al., 2010; Hayase, 2007; Hayase, 2011). In addition, nicotine withdrawal syndrome has an affective component represented by anxiety- and depression-like symptoms (Kenny and Markou, 2001; Markou, 2008; Wonnacott et al., 2005), which are common in the withdrawal phase of all kinds of drug addiction.
برای دانلود رایگان مقاله بهبود آگونیست اینجا کلیک نمایید.
کلمات کلیدی:
Disruption of the CRF2 Receptor Pathway Decreases the ... - Nature www.nature.com/npp/journal/v33/n12/pdf/npp20088a.pdf?origin=ppub by F Papaleo - 2008 - Cited by 43 - Related articles Feb 20, 2008 - To investigate the role for the CRF2 receptor pathway in somatic opiate ... have greatly ameliorated the management of opiate with- drawal and ... CRF receptor antagonists reduce ..... receptor pathway increased the expression of anxiety-like and depression-like behavior, and exacerbated HPA axis res-. Neuropsychopharmacology - Disruption of the CRF2 Receptor ... www.nature.com › Journal home › Archive › Original Articles Feb 20, 2008 - Opiate-like drugs have greatly ameliorated the management of opiate ... CRF receptor antagonists reduce stress-induced reinstatement of ..... of the CRF1 receptor pathway decreased anxiety-like and depression-like behavior ... Miklos Palotai - Google Scholar Citations scholar.google.com/citations?user=UQEBuVMAAAAJ&hl=en Harvard Medical School, Brigham and Women`s Hospital - bwh.harvard.edu Neuropeptide AF induces anxiety-like and antidepressant-like behavior in ... Selective CRF2 receptor agonists ameliorate the anxiety-and depression-like state ... Corticotropin releasing factor receptor antagonists - Gut gut.bmj.com/content/53/7/919.full.pdf by Y Taché - 2004 - Cited by 52 - Related articles New corticotropin releasing factor (CRF) antagonists in irritable ... affinity for CRF1 than for CRF2 receptor, .... receptor antagonists for the treatment of anxiety, ... depression-like behavior in mice. ..... dietary change can ameliorate symp-. References in Role of neuropeptides in anxiety, stress, and ... www.neuropeptidesjournal.com/article/S0143-4179(13)00080-2/references Role of neuropeptides in anxiety, stress, and depression: From animals to humans ...... Takeda, M., Baba, A. Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone. ...... and neuroendocrine effects of the selective CRF2 receptor agonists urocortin ... [PDF]The Role of the Amygdala in Anxiety Disorders - InTech https://www.intechopen.com/download/pdf/41589 the amygdala function to ameliorate heightened fear and/or anxiety. This is important, given that ..... Furthermore, CRF2 receptor antagonists infused ...... Low Anxiety/Depression-Like Behaviour: Effects of Chronic Paroxetine Treatment. J. PDF (968 KB) - Cell Press www.cell.com/neuron/pdf/S0896-6273(12)00861-6.pdf by JR Schank - 2012 - Cited by 50 - Related articles Oct 4, 2012 - Ucn:s are high-affinity agonists for CRF2R, with varying degrees of affinity for CRF1R. .... Modulation of. LS function by CRF2 receptors may, however, also impact .... and high measures of both anxiety- and depression-like behav- iors that are ameliorated by alcohol consumption (Ciccocioppo et al., 2006 ...
