دانلود رایگان مقاله لاتین استرس اکسیداتیو از سایت الزویر
عنوان فارسی مقاله:
شناسایی استرس اکسیداتیو ناشی از مرگ سلول توسط سورافنیب و اولئانولیک اسید در سلول های سرطان کبد انسان
عنوان انگلیسی مقاله:
Identification of a novel oxidative stress induced cell death by Sorafenib and oleanolic acid in human hepatocellular carcinoma cells
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
HCC is the second most common cause of death from cancer worldwide and estimated to be responsible for nearly 745,000 deaths in 2012 [1]. Only 30–40% of patients are eligible for curative treatment, including liver resection, transplantation and percutaneous ablation [2,3]. At present, there is no effective systemic chemotherapy available for patients with advanced HCC. Sorafenib, an oral multikinase inhibitor, is currently the only routinely used chemotherapeutic drug, which improves the median survival and the time to radiologic progression up to 2.8 months compared to patients who received a placebo treatment [4]. Unfortunately, due to its toxicity, the administration of Sorafenib is reserved only to a limited group of patients. The underlying liver dysfunction in HCC patients, which leads to an even lower tolerance of treatment toxicity, presents a significant problem in the standard therapy with Sorafenib [5]. This highlights the need to develop novel strategies for the induction of cell death in HCC cells. Due to the lack of more effective treatment strategies in HCC, one strategy is to improve the efficacy of Sorafenib in HCC cells. Sorafenib has been reported to induce the generation of ROS in human HCC cell lines in vivo and in vitro in a dose-dependent manner [6,7]. The levels of ROS in Sorafenib-treated HCC patients correlate with the clinical efficacy of Sorafenib [6]. Another approach to induce ROS and cell death in HCC cells is the use of OA, a natural triterpenoid [8–10]. In Chinese medicine, OA has been used for many decades in the treatment of liver disorders such as viral hepatitis [8]. Recently, an antitumor effect of OA in vitro and in vivo has been shown in HCC [8]. We previously identified a novel synergistic induction of ROS production and cell death by combining the Smac mimetic BV6, which antagonizes Inhibitor of Apoptosis (IAP) proteins [11,12], and OA in human HCC cells [10]. Searching for new strategies to overcome Sorafenib resistance in HCC, in the present study we investigated the effects of the combination of Sorafenib and OA on human HCC cells.
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کلمات کلیدی:
Identification of a novel oxidative stress induced cell death by ... https://www.researchgate.net/.../306373352_Identification_of_a_novel_oxidative_stress... References, authors & citations for 'Identification of a novel oxidative stress induced cell death by Sorafenib and oleanolic acid in human hepatocellular ... IJMS | Free Full-Text | Oleanolic Acid Alters Multiple Cell Signaling ... www.mdpi.com/1422-0067/18/3/643/htm by L Žiberna - 2017 Mar 16, 2017 - Research Group on Community Nutrition and Oxidative Stress and ... Nowadays, cancer has been considered as an important cause of death and it is ..... Extrinsic apoptosis was induced in human lung cancer cells by oleanolic acid ... chemotherapeutic drug (sorafenib) in hepatocellular carcinoma [89]. Oleanolic Acid and Ursolic Acid Induce Apoptosis in HuH7 Human ... pubs.acs.org/doi/abs/10.1021/jf100574j by MH Shyu - 2010 - Cited by 128 - Related articles Apr 23, 2010 - Oleanolic acid (OA) and ursolic acid (UA) are commonly found in plants and ... of apoptosis in human hepatocellular carcinoma HuH7 cells and the .... novel oxidative stress induced cell death by Sorafenib and oleanolic acid ... Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse ... pubs.acs.org/doi/abs/10.1021/ja411006a by R Skouta - 2014 - Cited by 85 - Related articles Mar 4, 2014 - Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in ... Heat stress induces ferroptosis-like cell death in plants. Identification of a novel oxidative stress induced cell death by ... www.bioportfolio.com › Topics › Stress › Research Aug 17, 2016 - Summary of "Identification of a novel oxidative stress induced cell death by Sorafenib and oleanolic acid in human hepatocellular carcinoma ... [PDF]Identification of a novel oxidative stress induced cell death by ... iranarze.ir/wp-content/uploads/2016/10/E2303.pdf Identification of a novel oxidative stress induced cell death by Sorafenib and oleanolic acid in human hepatocellular carcinoma cells. Matthias Lange a,b, ... sorafenib - Results from #20 - OncToday https://www.onctoday.com/component/tags/tag/138-sorafenib.html?limit=10... Identification of a novel oxidative stress induced cell death by Sorafenib and oleanolic acid in human hepatocellular carcinoma cells. Published August 23, 2016 ... Identification of a novel oxidative stress induced cell death by ... www.drugpapers.com/.../Identification-of-a-novel-oxidative-stress-induced-cell-death... PDF Source for 'Identification of a novel oxidative stress induced cell death by Sorafenib and oleanolic acid in human hepatocellular carcinoma cells.' : The lack ...
