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عنوان فارسی مقاله:
آدنوکارسینوما ریه جهش KRAS G12V ناشی از تشعشع در یک فرد غیر سیگاری
عنوان انگلیسی مقاله:
Radiation-induced KRAS G12V mutant lung adenocarcinoma in a never smoker
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Radiation-induced secondary cancers represent a major clinical concern. Given the prolonged interval between treatment and cancer development, risks are most apparent among individuals cured from their initial cancer. Hodgkin's lymphoma is the paradigm of this clinical scenario. Hodgkin's survivors treated with thoracic radiation face a lung cancer relative risk of 2.6–7.0 compared to the general population [1]. Risk is particularly heightened for individuals treated prior to the widespread use of involved- field radiotherapy, which has substantially reduced the likelihood of secondary malignancies. In some models, the use of involved- field in contrast to extended-field (mantle field) radiation therapy may reduce excess relative risk of lung cancer by more than 50% [2]. Radiation-induced secondary cancers have been noted as early as 1–4 years after treatment, and the excess risk from radiation is thought to last up to 20–25 years [3]. Relatively little is known about the molecular phenotype of radiation-induced lung cancers. In a recent report of seven lung adenocarcinomas attributed to prior radiation therapy in Hodgkin's survivors for which mutational analyses were performed,two cases had EGFR mutations [4]. In an earlier series of 19 secondary primary lung cancer cases after Hodgkin's radiation therapy, TP53 mutations were identified in 11 (58%) and KRAS mutations were detected in two (11%) [5]. The identified KRAS mutations (G12C and G13D) occurred in current or former smokers. Herein we report a case of radiation-induced lung cancer in a never smoker harboring a characteristically smoking-associated KRAS G12V mutation. The identification of such a case highlights the potential of radiation therapy to induce a variety of molecular alterations and the importance of evaluating radiation-induced lung cancers for driver mutations.
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کلمات کلیدی:
L858R-positive lung adenocarcinoma with KRAS G12V, EGFR T790M ... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533255/ by X XIANG - 2015 - Cited by 2 - Related articles Jun 30, 2015 - L858R-positive lung adenocarcinoma with KRAS G12V, EGFR T790M and EGFR ... shadow in the right upper lung that was identified on chest X-ray. ... and gefitinib (250 mg/day) for 3 weeks, which induced infusion reaction. Aurora kinase targeting in lung cancer reduces KRAS-induced ... https://www.ncbi.nlm.nih.gov › NCBI › Literature › PubMed Central (PMC) by EO dos Santos - 2016 - Cited by 3 - Related articles Feb 3, 2016 - KRAS induces expression of AURKA and AURKB in lung cells. a Protein .... 5c, right panel) of H1703 G12V cells induced to express KRASG12V with ...... the tumor microenvironment influence radiation-induced apoptosis? A comprehensive survey of Ras mutations in cancer - NCBI - NIH https://www.ncbi.nlm.nih.gov › NCBI › Literature › PubMed Central (PMC) by IA Prior - 2012 - Cited by 410 - Related articles In contrast, H-Ras favours G12V in all cancers with codon 12 mutations and ... 12 and chemical or UV-radiation induced damage for Q61 mutations in N-Ras. Acute DNA damage activates the tumour suppressor p53 to promote ... https://www.nature.com › Nature Communications › Articles by CL Lee - 2015 - Cited by 6 - Related articles Sep 24, 2015 - To study how blocking p53 during TBI affects radiation-induced clonal ... TBI activates p53 to expand KrasG12D-expressing thymocytes. [PDF]KRAS-G12C Mutation Is Associated with Poor Outcome in Surgically ... www.jto.org/article/S1556-0864(15)30708-5/pdf by E Nadal - 2014 - Cited by 10 - Related articles AKT-inducing inhibition of apoptosis.8 At least nine specific. KRAS mutations have been ... predicted different clinical outcomes.10 For example, KRAS-G12C and KRAS-G12V pre- ... preoperative radiation or chemotherapy. Tissue specimens. EGFR-Mediated Chromatin Condensation Protects KRAS-Mutant ... cancerres.aacrjournals.org/content/canres/early/.../0008-5472.CAN-13-3157.full.pdf by M Wang - 2014 - Cited by 21 - Related articles Exposure of cellular DNA to ionizing radiation (IR) generates various types of damage (1). A ... condensation protects KRAS-mutant cancer cells against IR-induced DSB ... pBABE-Puro vector encoding KRAS G12V or an empty control (kindly ...
