دانلود رایگان مقاله لاتین یادگیری هیجانی در موش ناک اوت از سایت الزویر
عنوان فارسی مقاله:
اختلال نقص در یادگیری هیجانی در موش ناک اوت neurotrimin
عنوان انگلیسی مقاله:
Deficit in emotional learning in neurotrimin knockout mice
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Neurotrimin (Ntm), in humans also called human neurotrimin (Hnt), is a glycophosphatidylinositol (GPI)-anchored cell-adhesion molecule belonging to the IgLON protein family with Lsamp (also Lamp), Obcam (also Opcml) and kilon (also Negr1) [31]. It has been shown that Ntm, and other members of the IgLON family, regulate the development of neuronal projections via cell type specific attractive and repulsive mechanisms that are mediated by both homophilic and heterophilic interactions [6,7,17]. Reed et al. [29] have suggested that only Ntm might be both a homo- and a heterophilic cell adhesion molecule, whereas Lsamp and Obcam act only as heterophilic cell adhesion molecules. Lodge et al. [18] have shown that GPI-anchored Ntm has an alternatively-spliced isoform, possibly modulating the activity of all the IgLONs, that is secreted and co-expressed with the anchored version of the protein in the retina, cerebellum, and DRG neurons. In DRG neurons, Ntm promotes neurite outgrowth via Ntm forming noncovalent homodimers in the plane of the membrane. Conversely, Ntm inhibits neurite outgrowth in sympathetic neurons via heterophilic interactions because sympathetic neurons do not express Ntm [30,34]. McNamee et al. [21] have proposed that IgLONs may not have a primary role in axon guidance, but may be even more important for cell-cell adhesion and recognition. According to the Eurexpress transcriptome atlas created by Diez-Roux et al. [5], there is a strong widespread expression of Ntm in mouse E14.5 embryonic brain, spinal cord, peripheral nervous system, ganglia, eye, skeleton and limbs. Gil et al. [7] have shown that in adult rat brain, Ntm protein is largely expressed in a complementary pattern to that of Lsamp in the nervous system, with co-expression at a few sites. Ntm is expressed at high levels in sensory-motor cortex and, of particular note, is transiently expressed in neurons of cortical barrel fields and corresponding thalamic “barreloids”. Ntm is expressed also in the spinal cord [8] and is mediating estrogen-induced sympathetic pruning in some peripheral targets like myometrium; estrogen increases Ntm synthesis and secretion in myometrial smooth muscle cells, so Ntm seems to contribute to sympathetic myometrial neurodegeneration elicited by estrogen [13]. The spatial-temporal expression pattern of Ntm suggests that this adhesion molecule plays a role in axonal fasciculation of specific cerebellar systems and may also be involved in the formation of excitatory synapses and their stabilization into adulthood as it accumulates coincident with synaptogenesis [3],however,inhippocampalneurons in vitro, overexpression of Lsamp or Obcam increased synaptic number, while the over-expression of kilon reduced synaptic number and Ntm had no effects [9]. Ntm also mediates the inhibition of Schwann cell proliferation andmigration following nerve injury repair through rapid regulation of a certain microRNA (miR-182) which targets FGF9 and Ntm [38].
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کلمات کلیدی:
IgLON cell adhesion molecules regulate synaptogenesis in ... onlinelibrary.wiley.com/doi/10.1002/cbf.1600/abstract by T Hashimoto - 2009 - Cited by 32 - Related articles Aug 26, 2009 - Abstract. IgLON cell adhesion molecules (CAMs) belonging to the immunoglobulin superfamily comprise of LAMP, neurotrimin (Ntm), OBCAM, ... Article metrics for: Cell type- and brain region-resolved mouse brain ... www.nature.com › Home › archive › issue › Resource › Article › Article metrics Nov 2, 2015 - Deficit in emotional learning in neurotrimin knockout mice. Timur Mazitov,; Aleksandr Bregin,; Mari-Anne Philips,; Jürgen Innos,; Eero Vasar. Social Emotional Learning | Committee for Children www.cfchildren.org/second-step/social-emotional-learning Social-emotional learning is recognizing and managing emotions, having empathy for others, maintaining cooperative relationships, and making responsible ... Deficit in emotional learning in neurotrimin ... - Terkko Navigator https://www.terkko.helsinki.fi/.../15523176_deficit-in-emotional-le... Translate this page Deficit in emotional learning in neurotrimin knockout mice. Added 179 days ago (15.10.2016). Journal: Behavioural Brain Research · Google Translate ... SEL Impact - Casel https://www.casel.org/impact/ Teachers across America know that social and emotional learning is essential to student success in school, the workplace, and life. A survey of teachers ... Healthcare Database Search - HDAS - Journals and databases www.library.nhs.uk/hdas/simpleresults?Keyword=*Mice&Field... Deficit in emotional learning in neurotrimin knockout mice. Author(s) ... Neural oscillations as a bridge between glutamatergic system and emotional behaviors in ... Philips M[au] - PubMed Result bjgp.org/external-ref?access_num=Philips%20M&link_type=AUTHORSEARCH 3: Mazitov T, Bregin A, Philips MA, Innos J, Vasar E. Deficit in emotional learning in neurotrimin knockout mice. Behav Brain Res. 2017 Jan 15;317:311-318. doi: ...
