دانلود رایگان مقاله لاتین کاهش توده استخوان ران در موش از سایت الزویر
عنوان فارسی مقاله:
کاهش توده استخوان ران در هر دو موش با چربی خون با رژیم پرانرژی و ژنتیکی
عنوان انگلیسی مقاله:
Reduced femoral bone mass in both diet-induced and genetic hyperlipidemia mice
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Previous studies found an increased risk of osteoporosis in subjects with atherosclerotic diseases or metabolic syndrome, suggesting an underlying link may mediate those chronic metabolic diseases. Hyperlipidemia, especially hypercholesterolemia, serving as the most prominent and well-established risk factor for atherosclerosis and a major component of metabolic syndrome, has been suggested to be the possible link. For example, higher risk of hip fracture was found in women after a diagnosis of a cardiovascular disease [1]. In postmenopausal women not taking hormone replacement therapy, total cholesterol (TC) and low density lipoprotein (LDL) levels have been found to be negatively associated with bone mineral density (BMD) at all measured sites [2] . In Japanese postmenopausal women, higher LDL-C levels were associated with increased risks for non-vertebral fractures [3]. Hypercholesterolemia mice also present an osteoporotic phenotype, including increased osteoclasts (OCs), reduced trabecular number and mechanical properties [4]. Statins, the first-line drugs for hypercholesterolemia, show beneficial influence of increasing BMD and reducing fracture risk in humans [5,6]. Statins regulate lipid metabolism exclusively through liver, where they inhibit cholesterol synthesis, leading to increased LDL uptake by the hepatocytes. Therefore, it seems likely that the beneficial effects of statins originate mainly from lipid-lowering, and not from direct effects on bone. Low-density lipoprotein receptor-knockout (LDLR−/−) mice, presenting with markedly increased serum TC, LDL-C levels and moderately elevated triglyceride (TG) levels as a result of impaired removal of cholesterol-rich lipoproteins from the plasma compartment, are widely used animal models for studying mechanism underlying hyperlipidemia related diseases such as atherosclerosis, type 2 diabetes and nonalcoholic steatohepatitis [7,8]. Soares et al. found smaller trabeculae, thinner spongy bone and impaired biomechanical properties in LDLR−/− mice, rendering these mice were more prone to fracture [9]. Low-density lipoprotein receptor-related protein 5 (LRP5) and LRP6, members of the LDLR family, are co-receptors of Wnt signaling pathway and are all involved in lipid as well as bone metabolism. Human carrying LRP5 or LRP6 mutations exhibit hypercholesterolemia and impaired glucose tolerance [10,11]. On the other hand, mice with either heterozygous or homozygous mutations in LRP5 or heterozygous mutations in LRP6 show limb defects and decreased BMD [12]. Homozygous lossof-function mutations in LRP5 lead to the autosomal recessive osteoporosis-pseudoglioma syndrome (OPPG) in human, presenting with severe osteoporosis and early onset blindness [13]. Furthermore, individuals carrying LRP5 mutations showed lower BMD and higher prevalence of fractures accompanied by hypercholesterolemia [11]. The co-existence of deficient lipid and bone metabolism in carriers of mutant LDLR-related proteins further highlights their potential reciprocal interactions.
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کلمات کلیدی:
Hyperlipidemia induces resistance to PTH bone ... - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/jbmr.312/pdf by AP Sage - 2011 - Cited by 46 - Related articles Dec 15, 2010 - bone quality—cortical mineral content, area, and thickness. D-4F significantly ... PTH anabolism in mice with genetic and diet-induced hyperlipidemia. Methods. LdlrÀ/À and ApoeÀ/À mice (both on a C57BL/6 background) and. Hyperlipidemia induces resistance to PTH bone anabolism in mice via ... onlinelibrary.wiley.com/doi/10.1002/jbmr.312/full by AP Sage - 2011 - Cited by 46 - Related articles May 24, 2011 - Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids ... 2011 American Society for Bone and Mineral Research. ... from a genetic or a dietary source, lipid oxidation products attenuate osteogenic ... with a reduction in BMD and BMC in both mice and canines.9, 18, 19. Animal Models for the Study of Human Disease https://books.google.com/books?isbn=0124159125 P. Michael Conn - 2013 - Science For this reason, a diet-induced obesity mouse model has been used to study the ... animal models, both spontaneous and induced, available in different species, ... men.101 Osteoporosis is characterized by reduced bone mass (osteopenia), ... and a variety of genetically manipulated animals (Tables 16.3 and 16.4), and ... Adverse effects of hyperlipidemia on bone regeneration and strength onlinelibrary.wiley.com/doi/10.1002/jbmr.541/pdf by F Pirih - 2012 - Cited by 53 - Related articles Oct 10, 2011 - genetic mutations in cholesterol uptake and clearance, such as in low-density ... (10) Diet-induced hyperlipidemia is also associated with a reduction in bone mineral content and density in both mice and canines.(11–13) ... BMT- ABCA1 - The Journal of Lipid Research www.jlr.org/content/early/2015/11/03/jlr.M064303.full.pdf by C Tang - 2015 - Related articles Nov 3, 2015 - carbohydrate with added cholesterol (HFHSC); HDL, high density lipoprotein; LPS, ... in vivo using bone marrow transplanted (BMT) wild-type (WT) (BMT-WT) ... macrophage inflammation and diet-induced atherosclerosis in mice (18, 23). .... increased both body mass and adiposity, there were no significant ... Hyperlipidemia Promotes Osteoclastic Potential of Bone Marrow Cells ... atvb.ahajournals.org/content/early/2003/12/11/01.ATV.0000112023.62695.7f.full.pdf marrow preosteoclasts derived from mice with genetic and diet-induced hyperlipidemia and from controls. Results showed that osteoclastic activity was greater ... Quercetin improves high-fat diet induced bone loss in obesity-prone ... www.fasebj.org/content/30/1_Supplement/lb241.short?related-urls=yes&legid... Quercetin improves high-fat diet induced bone loss in obesity-prone mice ... Bone formation related gene expression and osteoclast differentiation related gene ... Results Body weight of DIO-Q mice were 12.5% lower than DIO mice. ... (P<0.05), and MDA were both significantly higher than that of the control group (P<0.05).
