دانلود رایگان مقاله لاتین ژنومیک شخصی از سایت الزویر
عنوان فارسی مقاله:
نگرش نسبت به ژنومیک شخصی در میان بزرگسالان قدیمی سوئیس
عنوان انگلیسی مقاله:
Attitudes towards personal genomics among older Swiss adults: An exploratory study
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
The emergence of increasingly inexpensive genome sequencing technologies has increased our potential to identify genetic components of health and disease, thereby contributing to progress towards more individualized, predictive, preventive and precise medicine (Van El et al., 2013). To facilitate this development, genome-wide association and gene–environment interaction studies have become valuable resources for investigating the genetic basis of disease. Capitalizing on hopes and expectations regarding personalized medicine, commercial companies began offering large-scale personal genomic testing and disease-risk profiling outside clinical settings in 2007. Such companies appeared in many countries, operating via online interfaces and initially using a direct-to-consumer approach (DTC) whereby users order tests online and receive personal predictive risk assessments for a variety of diseases directly, without the mediation of a health professional (Vayena and Prainsack, 2013). However, the analytical validity, clinical utility of such tests including the appropriate involvement of health care providers have been highly contested, and significant debate has surrounded these companies ever since their first emergence (Bloss et al., 2013; Vayena et al., 2014a; Vayena, 2014). The leading company in this area remains 23andme, claiming to have one million genotypes in their database (23andme, 2015). Since November 2013, at the request of the US FDA, the company can offer only limited health risk information depending on whether the FDA has been provided with sufficient evidence of the link between a variant and a condition. In the UK, the same company offers a wider range of health risk information as the UK regulators have not stepped into controlling the services. Expert views differ over whether this type of genomic risk information has any value for disease prevention or would only inappropriately burden individuals and the healthcare system (Bloss et al., 2013 & McGowan et al., 2014). Systematic evidence of the impact of personal genomic information on behavior and health outcomes remains limited. Overall, early findings indicate increased physician utilization by DTCPG customers (Bloss et al., 2014). Healthier lifestyle changes on the basis of genomic results was only reported by Egglestone et al., (2013), while others observed no changes or even decreased self efficacy and control over one's health (Bloss et al., 2013; Boeldt et al., 2015). Further, differences in anxiety levels or after test distress in DTCPG users were reported as non-significant and correct interpretation and understanding of PG findings varies with demographic characteristics, level of education and numeracy, genetic knowledge and the format in which the information is presented (Ostergren et al., 2015; Schmidlen et al., 2015). Most findings come from early adopters of DTC-PG. We are still lacking conclusive evidence of how lay people receiving complex genomic information would react to it, given the limited genomic literacy in the general public (Carere et al., 2015; Critchley et al., 2015a, b; Boeldt et al., 2015 Meisel et al., 2015; Ostergren et al., 2015 Schmidlen et al., 2015; Gigerenzer et al., 2007; Gigerenzer and Muir Gray, 2011; Wasson et al., 2013)
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کلمات کلیدی:
Motivations, concerns and preferences of personal genome ... - Nature www.nature.com › Journal home › Archive › Articles Jun 3, 2015 - The study was open to interested adults aged 18 years or older and who were ... Intentions regarding personal results and informed consent choices regarding .... Among participants who did have concerns, three overarching ... Journal of Human Genetics - Effect of genomics-related literacy on non ... www.nature.com › Journal home › Advance online publication › 11 May 2017 May 11, 2017 - Association between genomics-related literacy, calculated as the genomics literacy ... cohort study of the general Japanese population over 40 years old. ..... M. C. Public attitudes towards preventive genomics and personal ... Medical and graduate students' attitudes toward personal genomics https://www.nature.com/gim/journal/v13/n5/pdf/gim9201169a.pdf?origin=ppub by KE Ormond - 2011 - Cited by 36 - Related articles assess knowledge, attitudes, and beliefs of students toward personal ... Key Words: personalized genotyping, personalized genomic testing, ..... P values indicate significant values between precourse and postcourse surveys using ..... aYou have a 37-year-old patient who has a family history of breast and ovarian cancer ... Yet another trial by press release for personal genomics | WIRED https://www.wired.com/2011/.../yet-another-trial-by-press-release-for-personal-genom... May 31, 2011 - This time it's about attitudes towards personal genomics among clinicians, based on “a survey of a representative sample of clinical geneticists ... CyberGenetics: Health genetics and new media - Google Books Result https://books.google.com/books?isbn=1317368177 Anna Harris, Susan Kelly, Sally Wyatt - 2016 - Social Science Health genetics and new media Anna Harris, Susan Kelly, Sally Wyatt ... (2013) 'Attitudes towards Social networking and sharing behaviors among consumers of direct-toconsumer personal genomics', Joz////a/o//e/Woma//zed///eas/c/me, ... The lay diagnosis of two common illnesses among older British people', SocialScience. Exploring Personal Genomics - Page 176 - Google Books Result https://books.google.com/books?isbn=0199644489 Joel T. Dudley, Konrad J. Karczewski - 2013 - Medical Clinical assessment incorporating a personal genome. ... on the individual's health risks, which, ironically, is age-old wisdom that did not require ... database of known etiological associations between diseases and environmental factors.
