دانلود رایگان مقاله لاتین ژل پکتین سیلیکا از سایت الزویر
عنوان فارسی مقاله:
ژل پکتین-سیلیکا به عنوان دی ماتریکس برای آزادسازی دارو کنترل شده در دستگاه گوارش
عنوان انگلیسی مقاله:
Pectin-silica gels as matrices for controlled drug release in gastrointestinal tract
سال انتشار : 2016
برای دانلود رایگان مقاله ژل پکتین سیلیکا اینجا کلیک نمایید.
مقدمه انگلیسی مقاله:
1. Introduction
Ulcerative colitis is the one of the most severe diseases of the digestive system. Prevalence of the disease is increasing with time and in different regions around the world (Latella & Papi, 2012; Ouyang et al., 2005). According to the epidemiological studies, the total number of patients with ulcerative colitis is from 25 to 240 per 100 thousand. The mortality rate ranges from 0.4 to 0.7 per 100 thousand populations per year (Kappelman et al., 2008; Kornbluth & Sachar, 2010; Munkholm, 2003; Satyrova & Mikhailova, 2010). An increasing number of diseases, attaches social importance to problem of medical treatment of ulcerative colitis. The disease has a significant impact on the quality of life for the majority of patients (Boonen et al., 2002). Patients with ulcerative colitis often require hospitalization, specialized medical care and regular intake of medicines (Longobardi, Jacobs, & Bernstein, 2004). Nowadays, the main drugs in the treatment of ulcerative colitis are the products based on the 5-amino salicylic acid (mesalazine) (Desreumaux & Ghosh 2006; Iacucci, de Silva, & Ghosh, 2010). The major limitation for its oral administration is the instability under the stomach conditions and rapidlymetabolized and inactivated inthe intestinal mucosa, becoming inactive N-acetyl-5-aminosalicylic acid, which leads to low efficiency and other serious side effects (Desreumaux & Ghosh, 2006; Schroeder, 2002). Effects from mesalazine are dosedependent, so it is important to ensure necessary concentrations of mesalazine in the field of inflammation. Therefore, the creation of effective coatings, which will prevent unwanted loss of mesalazine in the unaffected areas of the gastrointestinal tract (GIT) and thus ensure maximum delivery to the colon, is an urgent task. The creation of hybrid materials consisting of biopolymers and inorganic complexing agent develops rapidly nowadays. Organosilicon compounds occupy a special place among the hybridmaterials. It is shown that porous silicon-based materials can biodegrade in the gastric environment, and silicone is a suitable material for the encapsulation, transmission and effective release of drugs (Salonen, Kaukonen, Hirvonen, & Lehto, 2008; Vivero-Escoto, Slowing, Trewyn, & Lin, 2010). In the preparation of organosilicon compounds in particular polysaccharide-silicɑ compounds, different precursors such as tetraethyl orthosilicate (TEOS) (Angelova, Rangelova, Yuryev, Georgieva, & Muller, 2012; Assifaoui, Bouyer, Chambin, & Cayot, 2013; Rangelova, Aleksandrov, Angelova, Georgieva, & Muller, 2014; Samuneva et al., 2008), sodium metasilicate (Nurdin & Purwasasmita, 2013; Wu et al., 2011) and tetrakis (2-hydroxyethyl) orthosilicate (Shchipunov & Karpenko, 2004) are used. One of the most desirable biopolymers for the preparation of protective coatings is pectin. Pectin demonstrates diverse physiological activities: immunomodulatory, antidotal, antioxidant, gastroprotective (Khasina, Sgrebneva, Ovodova, Golovchenko, &
برای دانلود رایگان مقاله ژل پکتین سیلیکا اینجا کلیک نمایید.
کلمات کلیدی:
Pectin-silica gels as matrices for controlled drug release in ... - NCBI https://www.ncbi.nlm.nih.gov/pubmed/27988004 by FV Vityazev - 2017 - Cited by 1 - Related articles Pectin-silica gels as matrices for controlled drug release in ... https://www.researchgate.net/.../308351265_Pectin-silica_gels_as_matrices_for_controll... The synthesis of pectin-silica gels for controlled drug release in gastrointestinal tract (GIT) using low methoxyl (LM) and high methoxy (HM) pectins and ... Oral Controlled Release Formulation Design and Drug Delivery: Theory ... https://books.google.com/books?isbn=1118060326 Hong Wen, Kinam Park - 2011 - Science Macheras P, Argyrakis P. Gastrointestinal drug absorption: is it time to ... and kinetics of drug release from matrix-based oral controlled drug delivery systems. Magnetic hyperthermia controlled drug release in the GI tract: solving ... www.nature.com › Scientific Reports › Articles by JC Bear - 2016 - Related articles Sep 27, 2016 - Magnetic hyperthermia controlled drug release in the GI tract: ... waxy matrix by radiofrequency was sufficient to melt the matrix in air and water ... Handbook of Polymers for Pharmaceutical Technologies, Structure and ... https://books.google.com/books?isbn=1119041368 Vijay Kumar Thakur, Manju Kumari Thakur - 2015 - Technology & Engineering More recently, combined matrix systems prepared with a mixture of an inert and a ... units in the gastrointestinal tract, reducing high local drug concentration. ... Drug release from inert matrix systems occurs by diffusion through the pores of the matrix ... of Polymeric Matrices for Controlled Drug Release 103 4.2.1 Inert Matrices. Controlled Drug Release of Highly Water-Soluble Pentoxifylline from ... link.springer.com/article/10.1023/A:1018944516678 by M Otsuka - 1994 - Cited by 34 - Related articles Controlled Drug Release of Highly Water-Soluble Pentoxifylline from Time-Limit ... was investigated for controlling drug release in the gastrointestinal tract. The system ... The drug release from the wax matrix increased significantly after tablet ... [PDF]Overview of Controlled Release Mechanisms - Springer www.springer.com/cda/content/document/cda.../9781461408802-c1.pdf?SGWID... distribution in the gastrointestinal (GI) tract, and releases drug by a controlled ..... In typical polymeric controlled release systems, the polymer matrix does not. Sparrho | Pectin-silica gels as matrices for controlled drug release https://www.sparrho.com/...matrices-for-controlled-drug-release-in-gastrointestinal.../... Pectin-silica gels as matrices for controlled drug release in gastrointestinal tract. Imported: 06 Oct '16 | Published: 25 Sep '16. Fedor V. Vityazev, Maiia I. Alginate/hydrophobic HPMC (60M) particulate systems: new matrix for ... www.scielo.br/scielo.php?pid=S1984-82502011000400021&script=sci_arttext by K Ghosal - 2011 - Cited by 12 - Related articles The release kinetics of the beads indicated a purely relaxation-controlled delivery, ... is an excellent matrix to formulate site-specific and controlled drug release ... in the gastrointestinal (GI) tract, more uniform drug absorption, less inter- and ...
