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عنوان فارسی مقاله:
پروستاگلاندین E2 تسهیل کننده جایگزینی درون سلولی گیرنده EP4 در سلول های بنیادی نورواکتودرمال NE-4C
عنوان انگلیسی مقاله:
Prostaglandin E2 facilitates subcellular translocation of the EP4 receptor in neuroectodermal NE-4C stem cells
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Prostaglandin E2 (PGE2) is a bioactive lipid derived from plasma membrane phospholipids, through enzymatic metabolism of arachidonic acid by cyclooxygenases -1 and -2 (COX -1,-2) and prostaglandin synthase [1]. PGE2 mediates biosynthetic pathways that regulate biological functions such as sleep, fever, inflammation, and pain [2]. PGE2 also plays a critical role in the proper development of the nervous system. It induces differentiation of neuronal cells [3] and plays a regulatory role in membrane excitability and synaptic transmission in neurons [4]. PGE2 can also increase dendritic length and alter neuronal firing activity in the brain [5]. PGE2 exerts it physiological function through its four cell surface G protein-coupled receptors (GPCRs) designated EP (E-Prostanoid) 1-4, with different affinities [1,6,7]. Activation of EP1 receptor is associated with an increase of intracellular calcium [Ca2þ]i, mediated by phospholipase C and inositol 1,4,5-triphosphate (IP3) [7,8]. EP2 and EP4 are coupled to the stimulatory Gs protein and cause an increase in cAMP through activation of adenylate cyclase [9], which in turn activates protein kinase A (PKA) and mediates phosphorylation of cAMP response element binding the protein (CREB) transcription factor [10]. Activation of a specific EP3 isoform, can both decrease and increase cyclic AMP (cAMP) and IP3. It is also shown that the EP4 receptor signaling can operate via Gi proteins- phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) pathways [11,12]. Interest in the PGE2/EP4 pathway is increasing given its diverse capability of regulating central nervous system activity [13]. EP4 has a protective function by reducing cerebral injury and improving functional outcome after stroke [14], and in suppressing brain inflammation [15]. The EP4 receptor has been suggested to contribute to PGE2-induced changes in body temperature [16]. Furthermore, EP4 activation can decrease the level of amyloid-beta in the brain and improve behavioral performance in a murine model of Alzheimer's disease [17]. The EP4 receptor along with EP3C (EP3γ) mediates PGE2-induced sensitization of sensory neurons [18]. PGE2-prolonged sensitization of nociceptive dorsal root ganglion neurons may also contribute to the transition from acute to chronic pain by facilitating EP4 receptor synthesis and anterograde axonal trafficking [19]. We have previously found that the PGE2/EP4 pathway plays an inhibitory role in regulating the intracellular calcium homeostasis in mouse neuroblastoma (Neuro-2a) cells via PI3K mechanism [20]. Expression of the EP4 receptor is higher during early neurogenesis as compared to later embryonic stages in mouse embryos suggesting its importance in the developing nervous system [21].
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کلمات کلیدی:
Prostaglandin E2 facilitates subcellular translocation of the EP4 ... www.sciencedirect.com/science/article/pii/S2405580816300851 by JM Davidson - 2016 - Related articles Jun 2, 2016 - EP4 receptors translocate to growth cones in differentiating NE-4C neuronal ... of the EP4 receptor in neuroectodermal (NE-4C) stem cells and ... Prostaglandin E2 facilitates subcellular translocation of the EP4 ... iranarze.ir/wp-content/uploads/2016/10/E1217.pdf Prostaglandin E2 facilitates subcellular translocation of the EP4 receptor in neuroectodermal NE-4C stem cells. Jennilee M. Davidson b,c, Christine T. Wong a,b, ... Prostaglandin E2 facilitates subcellular translocation of the EP4 ... https://www.researchgate.net/.../303771579_Prostaglandin_E2_facilitates_subcellular_tr... Download research paper (PDF): Prostaglandin E2 facilitates subcellular translocation of the EP4 receptor in neuroectodermal NE-4C stem cells on ... EP4 receptor localization in differentiated NE-4C cells. The EP4 ... https://www.researchgate.net/.../303771579_fig4_EP4-receptor-localization-in-differenti... The EP4...' from publication 'Prostaglandin E2 facilitates subcellular translocation of the EP4 receptor in neuroectodermal NE-4C stem cells' on ResearchGate, ... Relationship of EP1‐4 prostaglandin receptors with rat hypothalamic ... onlinelibrary.wiley.com/.../1096-9861(20001204)428:1%3C20::AID-CNE3%3E3.0.CO;... by T Oka - 2000 - Cited by 133 - Related articles Oct 26, 2000 - To investigate which subtypes of EP receptors mediate systemic ... In these nuclei, EP4 receptor mRNA was strongly expressed and the Fos-IR ... Potentiation of PGE2-mediated cAMP production during neuronal ... onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.2001.00577.x/abstract by SY Choi - 2001 - Cited by 26 - Related articles Oct 15, 2001 - Potentiation of PGE2-mediated cAMP production during neuronal differentiation of human neuroblastoma SK-N-BE(2)C cells ... Improvement of cognitive function in Alzheimer's disease model mice ... onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2011.07567.x/abstract by T Hoshino - 2012 - Cited by 22 - Related articles Jan 23, 2012 - Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP4 receptor ... [PDF]the role of lipid mediator prostaglandin e2 in early ... - YorkSpace yorkspace.library.yorku.ca/xmlui/.../Davidson_Jennilee_M_2015_Masters.pdf?...2 by JMANN DAVIDSON - 2015 - Related articles Apr 17, 2015 - subcellular localization of the EP4 receptor to the plasma .... differentiated neuroectodermal stem cells . .... Prostaglandin E2 facilitates subcellular translocation of the EP4 ... Differentiation of NE-4C stem cells into neurons
