دانلود رایگان مقاله لاتین پروتئین ماکروفاژ از سایت الزویر
عنوان فارسی مقاله:
تعاملات بین پروتئین ماکروفاژ اریتروبلاست و مهاجرت سلولی
عنوان انگلیسی مقاله:
Novel interactions between erythroblast macrophage protein and cell migration
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Cell migration forms the basis of essential functions of living systems such as wound healing, tissue remodeling, and embryogenesis. Also, cell migration plays a vital role in tumor cell motility in metastasis [1]. Similarly, migration of macrophages is crucial for a broad array of functions such as response to infection, and regeneration [2]. Conventionally, macrophages are considered to be the key regulators of inflammatory responses, but recently their role has been defined in many pathophysiological conditions such as atherosclerosis [3], rheumatoid arthritis [4], systemic lupus erythematous [5], and cancer [6]. Erythroblast macrophage protein was first identified via culture of erythroid progenitors and is present on both erythroblast and macrophage cells. Moreover, it mediates homophilic interactions between erythroblast and macrophage cells and facilitates enucleation of erythroblasts [7]. Subunits of Emp include a relatively small, extracellular amino terminus involved in cell-to-cell contact, a single transmembrane domain, and a large cytoplasmic domain involved in downstream signaling [8]. Previous studies demonstrated that Emp-null mice were not viable and had impaired development of both erythroid and macrophage lineages [9]. Furthermore, Emp-null macrophages were small, round, and had condensed, with less organized actin filaments resulting in the lack of cytoplasmic projections, and demonstrate immature macrophage morphology. Emp expression is intense in the nuclei of immature macrophages, and increases at the plasma membrane and all along the microspikes in mature macrophages [10,11]. However, how the differential expression of Emp is correlated to its functions is unknown. Therefore, the present study addresses the role of differential expression of Emp in macrophages in relation to its pathophysiology to mimic the malignancy. In the present study, we utilized the GIPZ lentiviral shRNA gene silencing system to down-regulate expression of Emp and evaluated its role in macrophage cell motility. Since little is known about how
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کلمات کلیدی:
Absence of Erythroblast Macrophage Protein (Emp) Leads to Failure ... www.jbc.org/content/281/29/20181.full by S Soni - 2006 - Cited by 101 - Related articles Jul 21, 2006 - Abstract. In mammals, the functional unit for definitive erythropoiesis is the erythroblastic island, a multicellular structure composed of a central ... EmuJ_000079900 - Erythroblast macrophage protein EMP ... - UniProt www.uniprot.org/uniprot/A0A087VXP1 Hide 10 20 30 40 50. MASAASCSEI ELTEYMGMKA VYELLNKKYR VNHRELEKNS ANLNRIIDKF 60 70 80 90 100. GNVNTSEEAA EFIGRVITAV RGSKRKADEI ... MAEA - Macrophage erythroblast attacher - Homo sapiens (Human ... www.uniprot.org/uniprot/Q7L5Y9 Recommended name: Macrophage erythroblast attacher. Alternative name(s):. Cell proliferation-inducing gene 5 protein. Erythroblast macrophage protein. Protein Fyv10/Macrophage erythroblast attacher (IPR027714 ... https://www.ebi.ac.uk/interpro/entry/IPR027714 This entry includes the yeast Fyv10 protein and the animal macrophage erythroblast attacher protein (EMP). Fyv10 is involved in the proteasome-dependent ... Erythroblast macrophage protein Antibodies - Antibody Resource Page https://www.antibodyresource.com/search/...7638.../erythroblast-macrophage-protein 69 Erythroblast macrophage protein antibodies from 17 antibody suppliers. Click each Erythroblast macrophage protein antibody that interests you to view the ... Research paper: Requirement for erythroblast-macrophage protein ... https://www.researchgate.net/.../5347892_Requirement_for_erythroblast-macrophage_p... Jan 25, 2017 - Emp, erythroblast-macrophage protein was initially identified as a mediator of erythroblast-macrophage interactions during erythroid ... WikiGenes - MAEA - macrophage erythroblast attacher https://www.wikigenes.org/e/gene/e/10296.html MAEA - macrophage erythroblast attacher ... and apoptosis, it appears likely that these novel members of the PMP22/EMP/MP20 protein family are also involved ...
