دانلود رایگان مقاله لاتین ویروسی فلاونوئید از سایت الزویر
عنوان فارسی مقاله:
فعالیت ضد ویروسی فلاونوئیدهای منتخب ضد ویروس چیکونگونیا
عنوان انگلیسی مقاله:
Antiviral activity of selected flavonoids against Chikungunya virus
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
The Chikungunya virus (CHIKV; genus Alphavirus, family Togaviridae) is an enveloped virus with a positive-sense single-stranded RNA genome (Johnston and Peters, 1996). CHIKV is transmitted through the bites of its vectors, Aedes aegypti and Ae. albopictus (de Lamballerie et al., 2008). In addition to its known endemic areas, which include parts of Africa, islands in the Indian and Pacific Oceans, southern Europe, and Southeast Asia (CDC, 2015), the virus has emerged in other areas. The outbreaks that occurred in Reunion and its neighboring islands in 2005 were among the worst cases ever reported. They involved about one-third of the population and led to more than 250 deaths among the 785,000 inhabitants (Bonn, 2006). Since then, sporadic epidemics have occurred. In October 2013, CHIKV cases were reported in Caribbean islands, from which the virus spread to South and Central America. Although the travelrelated cases seem more applicable in explanations of the existence of CHIKV in United States, the risk of autochthonous cases cannot be dismissed because the activity of the vectors are greater with changes in climate and temperature. As a result of the rapid dispersion of CHIKV, it was projected that more than 1 million people would be infected by the end of 2014 (Higgs and Vanlandingham, 2015). Between the year of 2014 and 2016, more 2 million cases of chikungunya were reported in America and another states in the region (Alfaro-Toloza et al., 2015; RodriguezMorales et al., 2015). CHIKV has three different genotypes, which were named after their region of origin: West African, Asian, and East/Central/South African (Powers et al., 2000). The CHIKV genome with ~11.8 kb contains two open reading frames, one that encodes for nonstructural proteins, including nsP1, nsP2, nsP3, and nsP4, and one for structural proteins such as capsid and the envelope proteins (E1, E2, E3, and 6 k) (Tsetsarkin et al., 2011). Although CHIKV belongs to the Old World alphaviruses, which generally cause polyarthritis and rashes, its new and unique pathogenicity has crossed into the encephalitic group (Smith et al., 2009; Gerardin et al., 2008). There is currently no specific approved antiviral agent or licensed vaccine to prevent CHIKV infection; the only available treatments are supportive, such as nonsteroidal anti-inflammatory drugs taken to alleviate arthralgia and myalgia (Gerardin et al., 2008). Ribavirin, as one of the approved broad-spectrum antiviral drugs, has been tested on patients with CHIKV infection and has led to improvements in joint pain, but further research should be conducted to confirm its effectiveness against CHIKV infection (Queyriaux et al., 2008; Ravichandran and Manian, 2008; Briolant et al., 2004). Many compounds such as arbidol, mycophenolic acid, harringtonine, and chloroquine have also shown antiviral activity against CHIKV in vitro and, more recently, in vivo (Delogu et al., 2011; Khan et al., 2011; Kaur et al., 2013; Shimizu et al., 1972). However, clinical trials have shown that chloroquine is ineffective against CHIKV infection (de Lamballerie et al., 2009).one for structural proteins such as capsid and the envelope proteins (E1, E2, E3, and 6 k) (Tsetsarkin et al., 2011). Although CHIKV belongs to the Old World alphaviruses, which generally cause polyarthritis and rashes, its new and unique pathogenicity has crossed into the encephalitic group (Smith et al., 2009; Gerardin et al., 2008). There is currently no specific approved antiviral agent or licensed vaccine to prevent CHIKV infection; the only available treatments are supportive, such as nonsteroidal anti-inflammatory drugs taken to alleviate arthralgia and myalgia (Gerardin et al., 2008). Ribavirin, as one of the approved broad-spectrum antiviral drugs, has been tested on patients with CHIKV infection and has led to improvements in joint pain, but further research should be conducted to confirm its effectiveness against CHIKV infection (Queyriaux et al., 2008; Ravichandran and Manian, 2008; Briolant et al., 2004). Many compounds such as arbidol, mycophenolic acid, harringtonine, and chloroquine have also shown antiviral activity against CHIKV in vitro and, more recently, in vivo (Delogu et al., 2011; Khan et al., 2011; Kaur et al., 2013; Shimizu et al., 1972). However, clinical trials have shown that chloroquine is ineffective against CHIKV infection (de Lamballerie et al., 2009).
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کلمات کلیدی:
Antiviral activity of silymarin against chikungunya virus : Scientific ... https://www.nature.com › Scientific Reports › Articles by R Lani - 2015 - Cited by 21 - Related articles Jun 16, 2015 - The mosquito-borne chikungunya virus (CHIKV) causes chikungunya ... Quercetin has antiviral activity against herpes simplex virus (HSV) type-1, ... Therefore it was chosen for a time-of-addition assay performed with aim to ... Antiviral activity of selected flavonoids against Chikungunya virus. www.unboundmedicine.com/.../Antiviral_activity_of_selected_flavonoids_against_Chik... Abstract. This study focuses on the antiviral activity of selected flavonoids against the Chikungunya virus (CHIKV), a mosquito-transmitted virus that can cause ... [PDF]COMPUTER AIDED PERSPECTIVE OF SELECTION OF PLANTS AGAINST VIRUSES ... https://sciforum.net/conference/ecsoc-18/paper/2490/download/pdf First the selection of a particular plant against viruses can be done ... Flavonoids, curcumin and other compounds gave good docking scores and better .... flavonoids, gallic acid gave good docking score against Dengue, Chikungunya and HIV. Therapeutics and Vaccines Against Chikungunya Virus | Abstract - DOIs doi.org/10.1089/vbz.2014.1681 Apr 21, 2015 - Therapeutics and Vaccines Against Chikungunya Virus .... Towards Exploring Potential Anti-Chikungunya Activity of Selected Flavonoids. Dana Vanlandingham | Faculty | DMP | College of Veterinary Medicine ... www.vet.k-state.edu › ... › Faculty and staff › Faculty Jan 3, 2017 - Evaluation of Simultaneous Transmission of Chikungunya Virus and ... Antiviral activity of selected flavonoids against Chikungunya virus. In silico study on anti-Chikungunya virus activity of hesperetin - PeerJ https://peerj.com/articles/2602.pdf by A Oo - 2016 - Related articles Oct 26, 2016 - against all four CHIKV non-structural proteins and SPK2. ... Chikungunya virus (CHIKV) is an arthropod-borne virus classified under the ... the specific as well as the surrounding palmitoylation site reduces virus replication ... Flavonoids are a group of polyphenolic plant compounds which are synthesised ...
