دانلود رایگان مقاله لاتین ویتامین e و آسیب دیواره آئورت از سایت الزویر
عنوان فارسی مقاله:
ویتامین E کم کردن آسیب دیواره آئورت ناشی از الکل در موش
عنوان انگلیسی مقاله:
Vitamin E attenuates alcohol-induced aortic wall damage in rats
سال انتشار : 2015
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مقدمه انگلیسی مقاله:
1. Introduction
The association between chronic ethanol consumption and the risk of cardiovascular morbidity is intricate. On one hand, it has been reported that light-to-moderate ethanol consumption reduces cardiovascular mortality as well as the prevalence of ischemic stroke.1 In addition, it has been reported that light-to-moderate ethanol consumption has also been implicated with lower incidence of heart attacks and angina pectoris.2,3 It has also been shown that light-tomoderate ethanol consumption inhibits the synthesis of prostacyclin, aggregation of platelet, endogenous plasminogen activator.4 Thus, the protective effect of moderate alcohol intake is largely due to with improved homeostasis and attenuated thrombosis. Long-term alcohol consumption, on the other hand, has been linked with adverse vascular effects.5 A growing body of evidence suggest that long term ethanol consumption impairs antioxidant balance through oxidative modification of biomolecules such as polyunsaturated fatty acid, proteins and DNA.6,7 We have recently demonstrated that long term ethanol administration (4.5 g/kg; 20% w/v in saline) once a day for six weeks induces the development of pro-inflammatory and pro-atherosclerotic processes including increased blood pressure, serum levels of C-reactive protein(CRP), intercellular adhesion molecule-1, endothelial leukocyte adhesion molecule-1 (E-selectin), and the appearance of infiltrated monocytes in the aorta, as well as foam-cell formation in early plaques.6 Based on the above-mentioned observations, we propose that the atherogenic effect of heavy long ethanol consumption is entirely or partially mediated by oxidative stress. To test this hypothesis, we attempted to investigate the role of oxidative stress in aorta VSMC proliferation in ethanol treated rats as well as the protective effect of vitamin E supplementation.
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کلمات کلیدی:
Melatonin and Vitamin C Attenuates Alcohol ... - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2009.00469.x/pdf by MF Sönmez - 2009 - Cited by 20 - Related articles At the end of the experiment, rats were killed and aorta tissues were removed. Some parts ... administration provide partial protection against alcohol-induced damage. ... 38039 Kayseri, Turkey (fax +90 352 437 52 85, e-mail drmfatihsonmez. Melatonin and Vitamin C Attenuates Alcohol-Induced Oxidative Stress ... onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2009.00469.x/abstract by MF Sönmez - 2009 - Cited by 20 - Related articles Oct 15, 2009 - ... and Vitamin C Attenuates Alcohol-Induced Oxidative Stress in Aorta ... Turkey (fax +90 352 437 52 85, e-mail drmfatihsonmez@hotmail.com). Melatonin and Vitamin C Attenuates Alcohol-Induced Oxidative Stress ... onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2009.00469.x/full by MF Sönmez - 2009 - Cited by 20 - Related articles Oct 15, 2009 - At the end of the experiment, rats were killed and aorta tissues were removed. ... Alcohol-induced oxidative stress is linked to the metabolism of ethanol [23]. ..... vitamin C or vitamin E, reduced vascular oxidative stress [47–49] ... Alcohol, Nutrition, and Health Consequences https://books.google.com/books?isbn=1627030476 Ronald Ross Watson, Victor R. Preedy, Sherma Zibadi - 2012 - Medical Sonmez MF, Narin F, Balcioglu E. Melatonin and vitamin C attenuates alcohol-induced oxidative stress in aorta. Basic Clin Pharm Toxicol. 2009;105:410–5. 88. Attenuation of Alcohol-Induced Apoptosis of Hepatocytes in Rat Livers ... onlinelibrary.wiley.com/doi/10.1111/j.1530-0277.2000.tb04592.x/abstract by LJ Mi - 2000 - Cited by 82 - Related articles Reprint requests: Charles S. Lieber, M.D., Alcohol Research Center, Bronx ... 130 West Kingsbridge Road, Bronx, NY 10468; Fax: 718-733-6257; E-mail: liebercs@aol.com ... PPC attenuates alcohol-induced apoptosis of hepatocytes; this effect may ... Behrouz Ilkhanizadeh, Vitamin E attenuates alcohol-induced aortic wall ...
