دانلود رایگان مقاله لاتین واسکولاریزاسیون تومور از سایت الزویر
عنوان فارسی مقاله:
افزایش واسکولاریزاسیون تومور با شیمی درمانی از طریق تشکیل سیگنالینگ شکاف اندوتلیال حاصل از تومور در سرطان پستان
عنوان انگلیسی مقاله:
Chemotherapy enhances tumor vascularization via Notch signalingmediated formation of tumor-derived endothelium in breast cancer
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Angiogenesis is essential for tumor growth and metastasis. The growth of solid tumors is strictly dependent on the development of an adequate blood supply through neoangiogenesis [1,2]. There are several known modes of blood-vessel formation in normal tissues. Vessel formation can occur by sprouting angiogenesis, by the recruitment of bone-marrow-derived and/or vascular-wallresident endothelial progenitor cells that differentiate into endothelial cells (ECs), or by a process of vessel splitting known as intussusception. Tumor vasculature is different from that in normal tissues. Unlike normal tissues, which use sprouting angiogenesis, vasculogenesis, and intussusception, tumors not only use all the above modes of vessel formation [3], but also co-opt preexisting vessels, or tumor vessels can be lined by tumor cells (vascular mimicry) or ECs with cytogenetic abnormalities in their chromosomes, derived from putative cancer stem cells. Numerous studies have demonstrated that the degree of tumor angiogenesis has prognostic impact in different malignancies [4]. In breast cancer, high tumor vascularity is correlated with poor outcome. Conversely, excellent survival has been found in a subset of patients who have tumors with low vascular density [4]. However, while traditional anti-angiogenesis strategies attempt to reduce the tumor vascular supply, their success is restricted by insufficient efficacy or the development of resistance. A phase III clinical trial in patients with advanced-stage triple-negative breast cancer indicated that the addition of bevacizumab, a neutralizing antibody to VEGF-A, to chemotherapy during adjuvant therapy did not improve invasive disease-free survival for patients with triple-negative breast cancer [5]. The mechanisms proposed to explain the resistance to anti-VEGF therapy have focused on the modes of tumor-vessel formation [6–8].
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کلمات کلیدی:
Endothelial cell differentiation of human breast tumour stem/progenitor ... onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2008.00338.x/full by B Bussolati - 2009 - Cited by 97 - Related articles Apr 10, 2008 - When cultured in the presence of serum, mammosphere-derived clones ... However, it is at present unknown whether breast cancer stem cells may exhibit ..... Vessels and tumour formation by endothelial differentiated tumour stem ..... via Notch signaling-mediated formation of tumor-derived endothelium in ... UCH-L1-containing exosomes mediate chemotherapeutic resistance ... onlinelibrary.wiley.com/doi/10.1002/jso.24614/full?scrollTo=references Mar 23, 2017 - Chemotherapy enhances tumor vascularization via Notch signaling-mediated formation of tumor-derived endothelium in breast cancer. CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is ... www.pnas.org/content/104/40/15735.full by Z Miao - 2007 - Cited by 523 - Related articles Oct 2, 2007 - Signaling mediated by the chemokine CCL5 and its receptor CCR5 in breast ... could be induced to be expressed on endothelial cells in culture models, and ... MDA MB 435s CXCR7 cells formed larger tumors than WT or MDA MB ... CXCR7 promotes growth of breast and lung cancer cell-derived tumors. Chemotherapy enhances tumor vascularization via Notch ... - ISI-dl isi-dl.com/item/93447 Chemotherapy enhances tumor vascularization via Notch signaling-mediated formation of tumor-derived endothelium in breast cancer. sciencedirect.com ... Glycans in Diseases and Therapeutics https://books.google.com/books?isbn=3642168337 Mauro S.G. Pavão - 2011 - Science Finally, the interplay of tumor cell-derived Sdc-1 and heparanase can even result in ... of Sdc-1 in MCF7 breast cancer cells result in an IL-8-dependent stimulation of ... 1.3, HSPGs regulate the process of angiogenesis and the formation of blood ... such as vascular endothelial growth factors (VEGFs), platelet-derived growth ... Biochemical pharmacology - Terkko Navigator https://www.terkko.helsinki.fi/.../15465096_chemotherapy-enhance... - Translate this page Oct 7, 2016 - Chemotherapy enhances tumor vascularization via Notch signaling-mediated formation of tumor-derived endothelium in breast cancer.
