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عنوان فارسی مقاله:
نوروژنومیک: فرصت ادغام علوم اعصاب، ژنومیک و بیوانفورماتیک پژوهش در آفریقا
عنوان انگلیسی مقاله:
Neurogenomics: An opportunity to integrate neuroscience, genomics and bioinformatics research in Africa
سال انتشار : 2015
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مقدمه انگلیسی مقاله:
1. Introduction
Human populations globally show genetic and genomic diversity. Improved understanding of this diversity can provide information that would shape the future of basic, applied and translational medicine (Gurdasani et al., 2015). Until recently, not much was known about genomic diversity among the different African populations. However, recent developments in research funding, training and infrastructure are making important contributions to building genomics research capacity on this continent (H3Africa Consortium et al., 2014). This means that major biomedical research questions relevant to the African population can be addressed by research scientists working in Africa. A significant example is the recent sequencing and assembly of the tsetse fly genome which is aiding in-depth studies into Human African trypanosomiasis disease biology (International Glossina Genome Initiative, 2014). Additionally, whole genome sequencing and bioinformatic analyses of patients' genomes during the recent Ebola virus disease outbreak provided vital information on disease epidemiology and future directions (Gire et al., 2014). The African Genome Variation Project also recently characterised genomic variations among certain key African ethnic groups (Gurdasani et al., 2015). These developments are a few examples demonstrating that genomics hold a lot of promise for biomedical research and medical care in Africa, particularly in providing insights into individual and population variations in disease susceptibility and resistance, as well as differential drug responses. The decreasing costs of high-throughput sequencing technologies also offer an opportunity to African laboratories in acquiring such technologies to advance their research activities (Karikari, in press). While genetics refers to the study of single genes and their associated biological effects, genomics is usually concerned about studying the totality of genes and non-coding elements in an individual's genome (i.e., the complete collection of genes and genetic material in the organism), in order to identify how these components function individually or collectively. Due to the wide coverage of sequencing technologies, it has been possible to extensively characterise genetic variants in populations studied to date, as well as gain in-depth insights into disease mechanisms and the development of potential therapies. Genomic diversity may lead to variations in the neural basis of development (neurodevelopment), behaviour (neurobehaviour), evolution (neuroevolution) and drug response (neuropharmacology); the study of these areas is referred to as neurogenomics (Boguski and Jones, 2004; Chandrasekaran et al., 2011; Deriziotis and Fisher, 2013; Tsuji, 2013). While genomics research is developing in Africa, there is limited application of these advances in neuroscience. Here, we discuss that the further development of neurogenomics in Africa would help to obtain further genomic-scale insights into neurological diseases, through the combined efforts of expertise in neurobiology, genome science and bioinformatics.
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کلمات کلیدی:
Neurogenomics - UCL www.ucl.ac.uk › UKPDC › Research Groups Feb 1, 2011 - Neurogenomics Group. The aim of our group is to translate recently discovered genetic risk traits for complex neurological and psychiatric ... Focus on neurogenomics : Nature Neuroscience : Nature Research www.nature.com › Home › archive › issue › Editorial May 27, 2014 - In this Focus on neurogenomics, we have compiled a series of Perspectives and Reviews on the success of genome-wide association and ... Neurogenomics: at the intersection of neurobiology and ... - Nature www.nature.com › Journal home › Archive › Perspective Apr 27, 2004 - Neurogenomics is the study of how the genome as a whole contributes to the evolution, development, structure and function of the nervous ... Neurogenomics: An opportunity to integrate neuroscience, genomics ... www.sciencedirect.com/science/article/pii/S221206611530003X by TK Karikari - 2015 - Cited by 12 - Related articles Jul 22, 2015 - Furthermore, neurogenomics would harness African scientists' expertise in neuroscience, genomics and bioinformatics to extend our ... Neurogenomics: An Egyptian perspective - NCBI - NIH https://www.ncbi.nlm.nih.gov › NCBI › Literature › PubMed Central (PMC) by WMY Mohamed - 2015 - Cited by 2 - Related articles May 5, 2015 - It has also spawned new fields, such as Genomics, which was born in Europe ( Goetz, 2004 ), and the sub-field neurogenomics, which ... Neurogenomics: at the intersection of neurobiology and ... - NCBI - NIH https://www.ncbi.nlm.nih.gov/pubmed/15114353 by MS Boguski - 2004 - Cited by 55 - Related articles Informatics Center for Neurogenetics and Neurogenomics (ICNN) https://www.semel.ucla.edu/core/icnn Informatics Center for Neurogenetics and Neurogenomics (ICNN). As with other areas of biomedical science, the post-genome era raises the prospect of ... Searches related to Neurogenomics neurogenomics definition neurogenomics genova frontiers in human neuroscience impact factor frontiers in neuroscience impact factor 2016 frontiers in neurology frontiers in cellular neuroscience nutrigenomics neuropharmacology
