دانلود رایگان مقاله لاتین نانودوت کربن فلورسنت از سایت الزویر
عنوان فارسی مقاله:
نانودوت های کربن فلورسنت برای تصویربرداری سلول های سرطانی
عنوان انگلیسی مقاله:
Fluorescent carbon nanodots for targeted in vitro cancer cell imaging
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Cancer is one of the deadliest human diseases [1] with over 10 million new cases reported every year [2]. The treatment of cancer is complex and requires targeted therapeutics along with a variety of nanoplatforms making it a thrust area of research [3,4]. Progress in biomedical fields [5,6] has taken early stage cancer diagnostics research to new dimensions [6–10] with great demand for high resolution optical imaging using organic dyes and inorganic nanoparticles (metal quantum dots) [11–15]. However, the use of various organic dyes and metal quantum dots as fluorescent probes for optical bioimaging [16–18] has been hampered due to poor photostability, low water solubility, high toxicity and low biocompatibility [19,20]. Recently, fluorescent carbon nanomaterials particularly quantum/nano dots has been materialized as the most attractive probes in nanomedicine [21–23] due to prolonged photostability, good water solubility, high biocompatibility and low toxicity [23–26]. In literature, number of publications withluminescence behavior of carbon quantum dots being obtained from various carbon sources by top-down and bottom-up approaches has been reported [27–38]. However, expensive precursors, long reaction time (2–3 days), sophisticated synthetic routes and harsh experimental conditions are barrier in the large scale synthesis of CQDs [37–44]. Additionally, large scale synthesis of photoluminescent carbon quantum dots within confined size limits (≤10 nm) with long-term photostability is still a challenge [45,46]. In the present investigation, we report an ambient large scale synthesis of green fluorescent carbon quantum/nano dots (GCQDs) and their potential application in early cancer diagnostics (Scheme 1). To obtain GCQDs, carbon fibers were subjected to chemical slicing. Here, we firstly report one pot large scale synthesis of GCQDs (>50% conversion efficiency) at ambient conditions. Folic acid (FA) was used as a targeting ligand to target the MCF-7 breast cancer cells through receptor mediated endocytosis. FA is a commonly used targeting ligand because of low molecular weight, good water solubility, high biocompatibility and over expression of folate receptors (FRs) on lung, breast, ovarian and renal cancer cells [47,48]. GCQDs-FA exhibited good biocompatibility and targeting ability leading to its high deep intracellular uptake and potential applications in cancer cell imaging. Additionally, we also report dual targeting ability of folic acid functionalized GCQDs (cell cytoplasm and nucleus) on MCF-7 breast cancer cell lines and high biocompatibility on L929 normal cells.
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کلمات کلیدی:
Highly Biocompatible Carbon Nanodots for Simultaneous Bioimaging ... onlinelibrary.wiley.com/doi/10.1002/adfm.201400961/abstract by Y Choi - 2014 - Cited by 63 - Related articles Jul 17, 2014 - ... (CD-PEG) for targeted delivery to FA-positive cancer cells, and ZnPc is ... targeted photodynamic therapy after irradiation in vitro and in vivo. Photoluminescent carbon nanotags from harmful cyanobacteria for ... https://www.nature.com › Scientific Reports › Articles by HU Lee - 2014 - Cited by 36 - Related articles Apr 11, 2014 - The cancer cell uptake and intracellular location of the G- and ..... In vivo cancer targeting and imaging with semiconductor quantum dots . Nat. In vivo: cancer targeting and imaging with semiconductor quantum dots www.nature.com › Journal home › Archive › Research › Article Jul 18, 2004 - We report the development of bioconjugated QD probes suitable for in vivo targeting and imaging of human prostate cancer cells growing in ... Functional manganese dioxide nanosheet for targeted photodynamic ... iopscience.iop.org/article/10.1088/2053-1583/aa652f/meta by S Kim - 2017 Apr 10, 2017 - ... for targeted photodynamic therapy and bioimaging in vitro and in vivo ... targeted delivery of ZnPc into folate receptor positive cancer cells and the ZnPc .... nanodots for simultaneous bioimaging and targeted photodynamic ... PEI–folic acid modified carbon nanodots for cancer cell-targeted ... pubs.rsc.org/-/content/articlehtml/2016/ra/c5ra27249a by J Wang - 2016 - Cited by 1 - Related articles Feb 9, 2016 - PEI–folic acid modified carbon nanodots for cancer cell-targeted delivery and two-photon excitation imaging .... In this study, we aimed to detect cancer cells overexpressing the folate receptor (FR) in vitro by using folic acid ... Measuring Biological Impacts of Nanomaterials https://books.google.com/books?isbn=3319248235 Joachim Wegener - 2016 - Science Tao HQ et al (2012) In vivo NIR fluorescence imaging, biodistribution, and ... Strongly green-photoluminescent graphene quantum dots for bioimaging applications. ... carbon dots as biocompatible nanoprobes for targeting cancer cells in vitro.
