دانلود رایگان مقاله لاتین میسل پلیمری هیالورونان از سایت الزویر
عنوان فارسی مقاله:
میسل های پلیمری هیالورونان برای دارورسانی موضعی
عنوان انگلیسی مقاله:
Hyaluronan polymeric micelles for topical drug delivery
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Nanosized materials such as liposomes, micelles, nanoparticles, nanoemulsions and polymeric suspensions are often reported to improve skin penetration of otherwise skin impermeable drugs into the stratum corneum, the topmost skin layer barrier (Karande & Mitragotri, 2009; Kong, Chen, Kweon, & Park, 2011; Lapteva, Mondon, Möller, Gurny, & Kalia, 2014; Lauterbach & MüllerGoymann, 2014; Yang, Bugno, & Hong, 2013). For this reason, colloidal nanosized systems have attracted great attention for topical administration of both cosmetically and pharmaceutically interesting compounds either for local or systemic delivery. At the same time, clinical applicability of the nanostructured systems as skin passive penetration enhancers is still under debate mainly due to the insufficient understanding of the interaction of nano-sized drug delivery vehicles with the skin. This also includes limited knowledge about the fate and deposition of the vehicle material and drug in the skin layers after application (Wu, Price, & Guy, 2009). Compared to larger particles, nanosized systems are more likely to penetrate the stratum corneum. In this way, the nanoparticles have higher probability to access in the deeper skin layers including the circulatory system (Wu, Price, & Guy, 2009) and for this reason the health risk should be always assessed, mainly in case of long term skin exposure to nanosized systems (Bolzinger, Briancon, & Chevalier, 2011). A number of attempts to make general rules regarding particle penetration from published results pointed out apparent inconsistences among the concluded observations (Bolzinger, Briancon & Chevalier, 2011; Contri, Fiel, Pohlmann, Guterres &, Beck, 2011; Prow et al., 2011). The reason for the data contradiction is probably the variety of nanomaterial constituents, used skin models and applied methodologies (Prow et al., 2011). The issue is quite complex and there is a number of potentially relevant parameters (Bolzinger, Briancon, & Chevalier, 2011). Besides the nanomate rial size, other physico-chemical properties of the system including surface chemistry, shape, charge, amphiphilicity, porosity, aggregation and elasticity significantly affect interaction of nanomaterials with skin (Bolzinger, Briancon, & Chevalier, 2011; Yang, Bugno, & Hong, 2013).
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کلمات کلیدی:
Hyaluronan polymeric micelles for topical drug delivery (PDF ... https://www.researchgate.net/.../307866730_Hyaluronan_polymeric_micelles_for_topic... Official Full-Text Publication: Hyaluronan polymeric micelles for topical drug delivery on ResearchGate, the professional network for scientists. Frontiers | Topical drug delivery by hyaluronan polymeric micelles www.frontiersin.org/10.3389/conf.FBIOE.2016.01.02378/.../event_abstract Mar 30, 2016 - Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes ... Hyaluronan polymeric micelles for topical drug delivery pubs.acs.org/doi/abs/10.1021/mp400639e by M Lapteva - 2014 - Cited by 26 - Related articles Jul 24, 2014 - Tacrolimus (TAC) suffers from poor cutaneous bioavailability when administered topically using conventional vehicles with the consequence ... Hyaluronan polymeric micelles for topical drug delivery | Masaryk ... https://www.muni.cz/en/research/publications/1354551 Original title, Hyaluronan polymeric micelles for topical drug delivery. Authors. Daniela Šmejkalová Kristina Nešporová Tomáš Muthný Martina ... Publication Records - IS MU https://is.muni.cz/publications/151062?lang=en - Translate this page Hyaluronan polymeric micelles for topical drug delivery ... Influence of serum albumin on intracellular delivery of drug-loaded hyaluronan polymeric micelles. Advanced Drug Delivery - Google Books Result https://books.google.com/books?isbn=1118662849 Ashim Mitra, Chi H. Lee, Kun Cheng - 2013 - Medical Topical delivery of hydrophobic drugs using a novel mixed nanomicellar ... targeting folate-conjugated hyaluronic acid polymeric micelles for paclitaxel delivery. Enhancing the transdermal penetration of nanoconstructs: could ... www.futuremedicine.com › Journal home › TOC Nanoconstructs, such as liposomes, polymeric micelles, gold nanoparticles, .... Hyaluronic acid: a unique topical vehicle for the localized delivery of drugs to the ... [PDF]03 cerutti www.ilasl.org/index.php/Incontri/article/download/267/273 by F Cilurzo - 2017 nanocarriers able to permeate the skin (e.g., polymeric nanoparticles, metal or solid-lipid, micro- and ...... Hyaluronan polymeric micelles for topical drug delivery. Drug Delivery - Page 52 - Google Books Result https://books.google.com/books?isbn=3642004776 Monika Schäfer-Korting - 2010 - Medical Adv Drug Deliv Rev 32:139–152 Woodle MC, Engbers CM, Zalipsky S (1994) New amphipatic polymer-lipid conjugates forming ... micelles for enhanced intracellular drug delivery to metastatic tumor cells. ... studies of hyaluronic acid- modified liposomes as bioadhesive carriers for topical drug delivery in wound healing.
