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عنوان فارسی مقاله:
تراکم مواد معدنی استخوان ناحیه ای و حجمی و خطر ابتلا به انواع مختلف از شکستگی در مردان مسن
عنوان انگلیسی مقاله:
Areal and volumetric bone mineral density and risk of multiple types of fracture in older men
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
With the increase in the average age of the world population, the number of osteoporotic fractures likely will increase [1]. Worldwide, the total disability adjusted life years (DALYs) lost attributed to fractures was about 58 million in 2008 [2]. Mortality and morbidity are two major consequences of osteoporosis, primarily due to hip fractures [3]. However, the public health impact of osteoporotic fractures is not limited to hip fractures. In Medicare enrollees, while hip fractures had the highest excess cost, many types of fractures were associated with higher health care expenditures [3, 4]. Low bone mineral density (BMD) is an established risk factor for fractures. Indeed, low areal BMD (aBMD) has been linked to most fractures in women except for the heel, ankle, and face [5]. To our knowledge, a similar analysis has not been carried out in older men. We previously showed that low aBMD was related to all non-spine fractures and hip fractures in older men [6,7]. Furthermore, Black et al. reported that a one standard deviation (SD) decrease in trabecular and cortical FN volumetric BMD (vBMD) were associated with a 2.2 and 1.7 increased risk of hip fracture respectively [8]. However, the association between multiple measures of aBMD and vBMD and risk of different types of fractures remains unexplored. Thus, the purpose of the current analysis was to assess the risk of multiple types of fractures in older men by aBMD and vBMD at multiple skeletal sites. A second aim was to compare fracture predictability of different BMD measurements. We hypothesized that older men with lower aBMD and vBMD will be at a higher risk for multiple types of fracture compared to older men with higher aBMD and vBMD respectively. Since the trabecular compartment is more metabolically active, we also hypothesized that older men with lower trabecular vBMD will be at higher risk for multiple types of fractures compared to older men with lower cortical vBMD.
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کلمات کلیدی:
Multiple Genetic Loci for Bone Mineral Density and Fractures — NEJM www.nejm.org/doi/full/10.1056/NEJMoa0801197 by U Styrkarsdottir - 2008 - Cited by 523 - Related articles May 29, 2008 - Multiple Genetic Loci for Bone Mineral Density and Fractures ... Bone mineral density influences the risk of osteoporosis later in life and is useful in the ... We have discovered common sequence variants that are consistently ... Who Will Have a Bone Fracture— Better Bones https://www.betterbones.com/fractures-and-healing/who-will-fracture/ Nov 3, 2015 - Beyond bone mineral density to the new world of fracture risk assessment ... factor like bone density, but rather in assessment of multiple risk factors. .... Secondary disorders linked to osteoporosis, such as type 1 diabetes ... What A Diagnosis Of Osteopenia Means For You— Better Bones https://www.betterbones.com/osteopenia/about-osteopenia/ Jul 7, 2016 - The term osteopenia refers to a bone density which is somewhat less, but not ... BMD at multiple sites and risk of fracture of multiple types: ... Osteoporosis - Wikipedia https://en.wikipedia.org/wiki/Osteoporosis Osteoporosis is a disease where increased bone weakness increases the risk of a broken bone. It is the most common reason for a broken bone among the elderly. .... Fracture risk calculators assess the risk of fracture based upon several criteria, ... risk; the heritability of the fracture, as well as low bone mineral density, ... Predictors of Fracture Risk and Bone Mineral Density in Men with ... https://www.hindawi.com/journals/jos/2011/924595/ by K Neubecker - 2011 - Cited by 6 - Related articles May 9, 2011 - Decrease of bone mineral density (BMD) and fracture risk is increased in .... Multiple linear regression analysis was conducted to further evaluate ... vertebral fracture of all types of FRAX scores: hip FRAX with or without BMD ... Fracture Risk Calculator https://courses.washington.edu/bonephys/FxRiskCalculator.html For FRAX in white women, use the either T-score or BMD. ... In the data-bases used to determine the FRAX risk, different studies used different types of fractures. Is Bone Mineral Density Predictive of Fracture Risk Reduction? www.medscape.com/viewarticle/472681_2 Bone Mineral Density Increase and Fracture Risk Reduction ... risk for each SD reduction in BMD, irrespective of fracture type and BMD measurement ... [13]) BMD = bone mineral density; MORE = Multiple Outcomes of Raloxifene Evaluation.
