دانلود رایگان مقاله لاتین مقاومت به آنتی بیوتیک در عفونت باکتریال گرم منفی در بیماران سرطانی از سایت الزویر


عنوان فارسی مقاله:

مقاومت به آنتی بیوتیک در عفونت باکتریال گرم منفی در بیماران مبتلا به سرطان


عنوان انگلیسی مقاله:

Antibiotic-Resistant Gram-Negative Bacterial Infections in Patients With Cancer


سال انتشار : 2014



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بخشی از مقاله انگلیسی:


ACINETOBACTER BAUMANNII 

Our understanding of the genetic diversity and the population structure of Acinetobacter has given rise to the concept of MDR clonal lineages. The predominant clone type has shifted from clonal cluster 3 (CC3 in the Pasteur scheme, or CC110 in the Oxford scheme) to clonal cluster 2 (CC2 or CC92), associated with carbapenem resistance mediated by the β-lactamase OXA-23 (oxacillinase) [27]. In Pittsburgh, where CC2 is prevalent, the mortality rate of patients with cancer and MDR Acinetobacter baumannii infection reached 55% [28]. Interestingly, a multivariate analysis revealed that the risk factors for acquisition of MDR A. baumannii were related to healthcare exposure, such as need for dialysis and length of previous intensive care, rather than to the underlying cancer [28]. In patients undergoing hematopoietic stem cell transplant, pneumonia (occurring after engraftment) was the main source of MDR A. baumannii bloodstream infections, with overwhelming mortality (95%) [29]. STENOTROPHOMONAS MALTOPHILIA The hallmark of Stenotrophomonas maltophilia is intrinsic antibiotic resistance. Its chromosome harbors 2 β-lactamases: L1, a metallo-β-lactamase with carbapenemase activity that does not hydrolyze aztreonam; and L2, a serine cephalosporinase that is inhibited by clavulanic acid. Additionally, S. maltophilia possesses a relatively impermeable membrane, and like P. aeruginosa, expresses efflux pumps and acquires additional resistance determinants in class 1 integrons. Trimethoprim-sulfamethoxazole (TMP-SMX) remains the main reliable antibiotic option to treat infections caused by S. maltophilia, although resistance to TMPSMX has emerged; tigecycline, minocycline, moxifloxacin, and, inparticular,colistinmayofferactivity [30].Bloodstreaminfection with S. maltophilia is associated commonly with central lines, and strong consideration should be given to catheter removal [31]. Patients with hematologic malignancy may develop fulminant hemorrhagic pneumonia caused by S. maltophilia [32].



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کلمات کلیدی:

Preventing Infections in Cancer Patients: Information for Patients and ... https://www.cdc.gov/cancer/preventinfections/patients.htm Oct 25, 2017 - What Is an Infection? You get an infection when germs enter your body and multiply, causing illness, organ and tissue damage, or disease. Bacteria and viruses cause infections. You can get bacteria from the air, water, soil, or food during the course of your medical treatment. Most bacteria come from your ... Antibiotics to prevent bacterial infections due to chemotherapy in ... www.cochrane.org/.../GYNAECA_antibiotics-prevent-bacterial-infections-due-chemo... Jan 18, 2012 - Antibiotics to prevent bacterial infections due to chemotherapy in cancer patients with a low white blood cell count and no fever. For patients receiving chemotherapy, there is an increased risk of infection due to a low white blood cell count ( neutropenia ) caused by a toxic effect of chemotherapy on the ... Searches related to Bacterial Infections in Patients With Cancer leukemia bacterial infections leukemia and infection leukemia infection symptoms common infections with leukemia how would you explain to a patient with leukemia the importance of avoiding bacterial infections leukemia infection death bacterial infections that cause cancer cancer infection symptoms