دانلود رایگان مقاله لاتین مقاومت انسولین برای عفونت هپاتیت c از سایت الزویر
عنوان فارسی مقاله:
تغییر در مقاومت انسولین با توجه به پاسخ ویروسی در طول درمان ضد ویروسی برای عفونت هپاتیت C
عنوان انگلیسی مقاله:
Change in insulin resistance according to virological response during antiviral treatment for hepatitis C virus infection
سال انتشار : 2015
برای دانلود رایگان مقاله مقاومت انسولین برای عفونت هپاتیت c اینجا کلیک نمایید.
مقدمه انگلیسی مقاله:
1. Introduction
Hepatitis C virus (HCV) infection is causally associated with impaired glucose homeostasis. Epidemiological surveys have consistently revealed a higher prevalence of insulin resistance and diabetes mellitus (DM) in HCVinfected patients than in the general population or in those with other chronic liver diseases [1e9]. HCV infection may cause insulin resistance, which is the essential component of metabolic syndrome and type 2 DM, through the direct involvement of viral proteins or as an indirect consequence of infection-related cytokine dysregulation [8,10e13]. Because chronic HCV infection is causally associated with impaired glucose homeostasis, it is plausible that viral clearance may ameliorate insulin resistance and prevent DM. Current evidence, however, remains inconclusive in con- firming the efficacy of successful HCV eradication in improving glucose intolerance. Several follow-up studies observing treated patients have reported encouraging results by demonstrating a lower incidence of new-onset type 2 DM in HCV-infected patients who achieved sustained virological response (SVR), as compared with those who could not clear the virus [14e16]. Nevertheless, these studies could not ascertain whether the apparent reduction of DM incidence was the result of viral eradication or simply reflected that patients who were more likely to develop DM were more difficult to treat. Several studies showed that HCV-infected patients with insulin resistance were more difficult to treat [17,18]. In order to elucidate how antiviral treatment as well as viral clearance may impact the glucose homeostasis in patients with HCV infection, it is imperative to measure insulin resistance alongside the therapeutic course. We conducted this study to explore the change in insulin resistance from the baseline, through the end of, and to 24 weeks after the standard regimen with pegylated interferon plus ribavirin. The association between viral clearance and amelioration of insulin resistance was assessed.
برای دانلود رایگان مقاله مقاومت انسولین برای عفونت هپاتیت c اینجا کلیک نمایید.
کلمات کلیدی:
Antiviral treatment in patients with hepatitis C virus-related cirrhosis ... https://www.ncbi.nlm.nih.gov › NCBI › Literature › PubMed Central (PMC) by P Toniutto - 2008 - Cited by 4 - Related articles Antiviral treatment in patients with hepatitis C virus-related cirrhosis awaiting liver ... With current treatment regimens, the rates of sustained virological response ... Change in insulin resistance according to virological response during ... www.sciencedirect.com/science/article/pii/S2351979715000225 by CH Tseng - 2016 - Cited by 2 - Related articles Mar 20, 2015 - In conclusion, antiviral therapy improves insulin resistance during HCV treatment. The durability persists only in patients who achieve SVR. ... Moreover, the reversibility of insulin resistance through viral eradication implicates tremendous clinical benefits by readily available regimens. Monitoring Patients Who Are Starting Hepatitis C Treatment, Are on www.hcvguidelines.org/.../monitoring-patients-who-are-starting-hepatitis-c-treatment-... All patients initiating HCV DAA therapy should be assessed for HBV coinfection with ... NS5A RASs appear to have impact on treatment response with regimens that include an NS5A ... Recommended Monitoring During Antiviral Therapy. Sustained Virologic Response to Antiviral Therapy for Chronic ... https://academic.oup.com/cid/.../7/.../Sustained-Virologic-Response-to-Antiviral-Therapy by BL Pearlman - 2011 - Cited by 218 - Related articles Apr 1, 2011 - In summary, chronic HCV infection is curable with SVR attainment, ... addressed HCV infection recurrence after antiviral therapy–induced SVR. Sustained Virologic Response to Antiviral Therapy ... - Oxford Academic https://academic.oup.com/cid/article-pdf/52/7/889/852267/cir076.pdf by BL Pearlman - 2011 - Cited by 218 - Related articles Sustained virologic response (SVR) is defined as aviremia 24 weeks after completion of antiviral therapy for chronic hepatitis C virus (HCV) infection. In analyses ... Mechanisms of non-response to antiviral treatment in chronic hepatitis C www.csih.org/sites/default/files/.../chevaliez_non-response-in-hcv_2011_review.pdf by A Part - Cited by 28 - Related articles Best Practice/Intervention: Chevaliez S. et al. (2011) Mechanisms of non-response to antiviral treatment in chronic hepatitis C. Clinics & Research in Hepatology ... Predictors of response to antiviral therapy for chronic hepatitis C virus ... https://www.uptodate.com/.../predictors-of-response-to-antiviral-therapy-for-chronic-... Nov 1, 2016 - (See "Treatment regimens for chronic hepatitis C virus genotype 1 infection in adults" and "Treatment regimens for chronic hepatitis C virus ... Hepatitis C Virus Therapy in the Direct Acting Antiviral Era - Medscape www.medscape.com/viewarticle/824178 The sustained virologic response (SVR) in treatment-naive patients is about 80%. Sofosbuvir, the first polymerase inhibitor, is effective in all HCV genotypes. Searches related to response during antiviral treatment for hepatitis C hep c viral load scale hep c viral load undetectable resistance associated variants hcv rav testing hcv hcv drug resistance testing after harvoni treatment hcv viral load test cost ns5a rav testing
