دانلود رایگان مقاله لاتین مضرات بنگال ماکرو ترومبو سیتو پنیا از سایت الزویر
عنوان فارسی مقاله:
بنگال ماکرو ترومبو سیتو پنیا کاملا بی ضرر نیست
عنوان انگلیسی مقاله:
Bengal macrothrombocytopenia is not totally an innocuous condition
سال انتشار : 2016
برای دانلود رایگان مقاله مضرات بنگال ماکرو ترومبو سیتو پنیا اینجا کلیک نمایید.
مقدمه انگلیسی مقاله:
1. Introduction
Abnormal giant platelets are sometimes seen as an incidental finding in routine blood examinations, many of them are associated with acquired disorder such as idiopathic thrombocytopenic purpura (ITP) and myelodysplasia. In contrast inherited macrothrombocytopenia comprises a heterogeneous group of rare disorders, characterised by abnormal giant platelets, thrombocytopenia and bleeding tendency with variable severity; from no or mild bleeding tendency to severe bleeding diathesis and sometimes associated with syndromic features like renal failure, hearing loss and presenile cataracts. Many of these disorders share common clinical and laboratory features, making accurate diagnosis difficult and patients are often misdiagnosed and treated for idiopathic thrombocytopenic purpura (ITP). Bleeding syndromes that arise through an inherited defect of platelet production and giant platelets constitute a heterogeneous group of platelet disorders [1,2], some including the Bernard-Soulier syndrome (BSS) [3], MYH9 related macrothrombocytopenia (MYH9-RD) [4,5] and Mediterranean macrothrombocytopenias (MM) [6], sitosteroleamia/phytosteroleamia [7,8], the disease is caused by a mutation in either of the ABCG5 or ABCG8 genes which encode an ATP-binding cassette protein called Sterolin [9,10], a rare X linked GATA-1 associated macrothrombocytopenia has been associated with dyserythropoiesis and thalassemia [11] and Harris platelet syndrome (HPS) in healthy donors from West Bengal [12]. Inherited macrothrombocytopenias were previously considered to be relatively rare, but their prevalence is likely under estimated from complexities of diagnosis and spectrum of subclinical phenotype and limited knowledge is available about them, recent progress in the elucidation of the responsible genes for several inherited macrothrombocytopenias led to advances in understanding the pathophysiology and pathogenesis of the disease, however, in approximately half of the cases with inherited macrothrombocytopenia, the molecular cause remain unknown [13]. One of the first inherited giant platelet disorder associated with abnormal red cell morphology was found in Mediterranean Macrothrombocytopenia (MM) reported in healthy Mediterranean immigrants to Australia, which was associated with stomatocytosis, macrothrombocytopenia and splenomegaly. Harris platelet syndrome (HPS) is the most common giant platelet disorder to be described [14] so far in healthy blood donors from the north-eastern part of the Indian subcontinent (Bhutan, Nepal and Bangladesh) and is characterised by mild to severe thrombocytopenia, with giant platelets, absent bleeding symptoms and normal platelet aggregation studies.
برای دانلود رایگان مقاله مضرات بنگال ماکرو ترومبو سیتو پنیا اینجا کلیک نمایید.
کلمات کلیدی:
Bengal macrothrombocytopenia is not totally an innocuous condition https://www.researchgate.net/.../303559814_Bengal_macrothrombocytopenia_is_not_tot... Sep 9, 2016 - Bengal macrothrombocytopenia is not totally an innocuous condition on ResearchGate, the professional network for scientists. Bengal macrothrombocytopenia is not totally an innocuous condition ... https://www.deepdyve.com/.../bengal-macrothrombocytopenia-is-not-totally-an-innocuo... Read "Bengal macrothrombocytopenia is not totally an innocuous condition" on DeepDyve - Instant access to the journals you need! Bengal macrothrombocytopenia is not totally an innocuous condition ... https://sfakianakismedblog.wordpress.com/.../bengal-macrothromb... Translate this page May 27, 2016 - Bengal Macrothrombocytopenia is a newly described entity, previously ... Bengal macrothrombocytopenia is not totally an innocuous condition. Bengal macrothrombocytopenia is not totally an innocuous condition. f1000.com/prime/pubmed/ref/27519935 Inherited macrothrombocytopenia is a subgroup of thrombocytopenias, and is characterised by the presence of giant platelets and decreased platelet count with ... Stomatocytic haemolysis and macrothrombocytopenia (Mediterranean ... onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2005.05599.x/full by DC Rees - 2005 - Cited by 83 - Related articles Jul 6, 2005 - The exact nature of this condition, now known as Mediterranean ..... She did not bruise easily but had an episode of haematoperitoneum, which ... Stomatocytic haemolysis and macrothrombocytopenia (Mediterranean ... onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2005.05599.x/abstract by DC Rees - 2005 - Cited by 83 - Related articles Jul 6, 2005 - Stomatocytic haemolysis and macrothrombocytopenia (Mediterranean ... condition that combines stomatocytic haemolysis with the presence of very large platelets. ... (ii) that phytosterolaemia, which does not respond to standard statin ... macrothrombocytopenia is not totally an innocuous condition, Blood ... PRIME PubMed | macrothrombocytopenia journal articles from PubMed www.unboundmedicine.com/medline/research/macrothrombocytopenia PubMed Journal articles for macrothrombocytopenia were found in PRIME PubMed. ... Bengal macrothrombocytopenia is not totally an innocuous condition.
