دانلود رایگان مقاله لاتین مدلسازی سینتیک بچ از سایت الزویر
عنوان فارسی مقاله:
مدلسازی سینتیک بچ تولید کاروتنوئید هوازی با استفاده از مخمر ساکارومایسس سرویزیه
عنوان انگلیسی مقاله:
Modelling of batch kinetics of aerobic carotenoid production using Saccharomyces cerevisiae
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Carotenoids, a diverse group of yellow-orange pigments found in many biological systems, are produced by diverse organisms such as plants, fungi, and bacteria [1–3]. Because of its colored characteristic, it has been extensively used in food pigmentation and as constituents in vitamins and dietary supplements [4–7]. Carotenes, such as -carotene, have important biological roles as a precursor of vitamin A. They have been shown to have positive impacts in human health, having antioxidant effects and properties protective against cancer [8–11]. Presently, some carotenoids are industrially produced by synthetic chemical technology; however some of the by-products have undesirable side effects when consumed and most of the carotenoids such as -carotene have a structural complexity that makes the chemical synthesis an unviable option. For this reason, the production of carotenoids from microbial sources has been the focus of vast literature references [4,12–15]. Overflow metabolism is the incomplete oxidation of the carbon source resulting in the excretion of generally inhibitory organic end products during aerobic operations. This phenomenon, also calledthe “short-term Crabtree effect”, manifests usually at a high substrate concentration [16,17]. Various microorganisms exhibit this phenomena, examples of which include Saccharomyces cerevisiae cultures withaerobic ethanolformation[18,19], Escherichia coli cultures with aerobic acetate formation [20,21], or mammalian cell cultures with aerobic lactate formation [22]. This inhibition effect is undesirable in many processes and leads to complications when trying to quantitatively describe these systems. Mathematical models describing the kinetics of microbial growth, substrate uptake and product formation are very useful for optimization, process control, the reduction of process operating costs, and the increase of product quality of cultivation processes. In this context, kinetic models have been reported for yeast systems such as Xanthophyllomyces dendrorhous [23,24] but there are very few studies dealing with appropriate modelling approach for engineered S. cerevisiae strains, and more specifically those engineered for the production of -carotene. The aim of this work is to develop a suitable and reliable kinetic model for the -carotene production in batch cultures of an engineered S. cerevisiae strain using glucose as the main substrate. This model is also applied to predict cell growth, substrate consumption, ethanol and acetic acid formation and later assimilation. Furthermore, sensitivities of various model parameters were studied to elucidate the need to focus on key model parameters.
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کلمات کلیدی:
9. Modelling of batch kinetics of aerobic carotenoid production ... - 首页 en.ruc.findplus.cn/search_list.html?h=articles&db=edsgao... Translate this page Modelling of batch kinetics of aerobic carotenoid production using ... a cents Models were proposed to predict production of carotenoids and other metabolites. a ... Sparrho | Modelling of batch kinetics of aerobic carotenoid productio https://www.sparrho.com/.../modelling-of-batch-kinetics-of-aerobic-carotenoid.../866... Jul 14, 2016 - Carotenes such as β-carotene have a positive impact in human health as a precursor of vitamin A. The structural complexity of these ... Modeling of Overflow Metabolism in Batch and Fed‐Batch Cultures of ... onlinelibrary.wiley.com/doi/10.1021/bp9801087/abstract by B Xu - 1999 - Cited by 174 - Related articles Abstract. A dynamic model of glucose overflow metabolism in batch and fed-batch cultivations of Escherichiacoli W3110 under fully aerobic conditions is ... [PDF]Kinetics of Bioethanol Production from Waste Sorghum Leaves Using ... www.mdpi.com/2311-5637/3/2/19/pdf by D Rorke - 2017 May 8, 2017 - Abstract: Kinetic models for bioethanol production from waste sorghum leaves by ..... J.P.; Jaladi, T.; Chen, X.; Kao, K.; Karim, M.N. Modelling of batch kinetics of aerobic carotenoid production using Saccharomyces cerevisiae. Thermal Food Processing: New Technologies and Quality Issues, Second ... https://books.google.com/books?isbn=1439876797 Da-Wen Sun - 2012 - Technology & Engineering Characterization and thermal lability of carotenoids and vitamin C of ... Kinetic modeling of anaerobic thermal degradation of ascorbic acid in rose hip ... Effect on orange juice of batch pasteurization in an improved pilot-scale microwave oven. [PDF]Karim CV - UNM School of Engineering https://engineering.unm.edu/news/2016/11/karim-cv.pdf Chair, Session on Model Predictive Control, AIChE Spring Meeting, San Antonio, TX ..... Modelling and sensitivity analysis of batch kinetics of aerobic carotenoid.
