دانلود رایگان مقاله لاتین مانع روده در مدل موش اندوتوکسمیا از سایت الزویر
عنوان فارسی مقاله:
GYY4137 ameliorates آسیب مانع روده ای در مدل موش اندوتوکسمیا
عنوان انگلیسی مقاله:
GYY4137 ameliorates intestinal barrier injury in a mouse model of endotoxemia
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Sepsis remains a leading cause of death in critically ill patients, the most common kind of which is caused by infection with Gramnegative bacteria, featured by increased level of lipopolysaccharide (LPS) in the blood, also known as endotoxemia [1]. Previous reports have revealed the vital role of intestinal barrier injury in the gut derived infection and the consequent septic multiple organ dysfunction in the pathogenesis of endotoxemia [2,3]. The intestinal barrier is mainly determined by tight junctions (TJs), which function as a physical barrier between the luminal content and the internal milieu [4]. Previous studies have reported that LPS was able to induce decreased expression of TJ proteins and altered localization of TJs via NF-KB mediated MLCK-P-MLC2 signaling, leading to the increased flux of noxious antigens in the lumen into the internal milieu, providing ‘‘fuel” for the unremitting inflammatory responses both locally and systematically [5–9]. Hydrogen sulfide (H2S) has been validated as the third ‘‘gasotransmitter” after carbon monoxide and nitric oxide [10,11]. The physiological function of H2S can be complex, including vasodilation, anti-inflammation and protecting gastric mucosal integrity [12–14]. In the previous reports from our laboratory and others, sodium hydrosulfide (NaHS) has been widely used as a donor to release H2S [15–17]. However, recent studies suggested that NaHS released large amounts of H2S over a few seconds under physiological conditions, which mimicked the toxic instead of the physiologic effects of H2S [18]. As a new synthetic compound, GYY4137 in aqueous solution was found to be able to release lower concentrations of H2S over longer time periods and thus was used in multiple studies regarding the effects of H2S [19,20]. However, the effect of GYY4137 on the intestinal barrier function in endotoxemia and the underlying mechanisms have not been illustrated. The current study indicates that GYY4137 preserves the intestinal barrier function in the context of endotoxemia via multipathways and throws light on the development of potential therapeutic approaches for endotoxemia.
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کلمات کلیدی:
PubPharm - GYY4137 ameliorates intestinal barrier injury in a mouse ... https://www.pubpharm.de/vufind/Record/1982051515 - Translate this page GYY4137 ameliorates intestinal barrier injury in a mouse model of endotoxemia. Enthalten in: Biochemical pharmacology : an international journal devoted to ... Elsevier Pharma on Twitter: "#Biochemical #Pharmacology #journal ... https://twitter.com/elspharma/status/769713885276504065 Aug 27, 2016 - #Biochemical #Pharmacology #journal GYY4137 ameliorates intestinal barrier injury in a mouse model of endotoxemia http://bit.ly/2bICEht. Xin Wang - Publications - Neurotree https://neurotree.org/beta/publications.php?pid=127981 Effect of Long Noncoding RNA H19 Overexpression on Intestinal Barrier ... Wang X, Pan Y, Wang P, Liu Y. GYY4137 ameliorates intestinal barrier injury in a ... SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in ... online.liebertpub.com/doi/abs/10.1089/ars.2015.6331 by L Xie - 2016 - Cited by 15 - Related articles Nov 10, 2015 - GYY4137, a slow-releasing H2S donor, improved cell viability, reduced ... GYY4137 ameliorates intestinal barrier injury in a mouse model of ... Hydrogen Sulfide Attenuates Inflammatory Hepcidin by Reducing IL-6 ... online.liebertpub.com/doi/abs/10.1089/ars.2015.6315 by H Xin - 2016 - Cited by 10 - Related articles GYY4137 ameliorates intestinal barrier injury in a mouse model of endotoxemia. Shanwen Chen , Dingfang Bu , Yuanyuan Ma , Jing Zhu , Lie Sun , Shuai Zuo ... Hydrogen Sulfide Attenuates Inflammatory Hepcidin by Reducing IL-6 ... dx.doi.org/10.1089/ars.2015.6315 GYY4137 ameliorates intestinal barrier injury in a mouse model of endotoxemia. Shanwen Chen , Dingfang Bu , Yuanyuan Ma , Jing Zhu , Lie Sun , Shuai Zuo ...
