دانلود رایگان مقاله لاتین ماتریکس سلولی آدیپوز در مقاومت به انسولین از سایت الزویر
عنوان فارسی مقاله:
مدلسازی مجدد ماتریکس خارج سلولی آدیپوز در مقاومت به انسولین و چاقی
عنوان انگلیسی مقاله:
Adipose extracellular matrix remodelling in obesity and insulin resistance
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
The global epidemic of overweight and obesity is escalating and has become a major health challenge. Obesity is implicated as a cause of many devastating diseases, including diabetes, cardiovas cular disorders, and cancers [1]. Insulin resistance is a pathological condition closely associated with obesity, which may underlie the links between obesity and chronic metabolic diseases [2]. Adipocytes undergo dramatic expansion during the development of obesity. At the same time, the adipose tissue of obese individuals becomes fibrotic in both subcutaneous and omental fat depots [3,4]. Of note, obese insulin-resistant subjects with a similar body mass index display increased fibrosis in adipose tissues than obese insulin-sensitive subjects [5]. These studies suggest that fibrosis in the adipose tissue is closely associated with obesity and insulin resistance. However, how adipose tissue fibrosis occurs and exerts its metabolic impacts on the pathophysiology of obesity and insulin resistance is unknown. It is suggested that the excess deposition of extracellular matrix (ECM) components, such as collagens and osteopontin (OPN), in adipose tissues triggers the necrosis of adipocytes, which attracts classically activated pro-inflammatory macrophages and causes tissue inflammation and metabolic dysfunction (Fig. 1). In addition to imposing physical restriction on adipose tissue expansion, excess ECM deposition may cause adipocyte death and adipose inflammation through the signalling via
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کلمات کلیدی:
Adipose Extracellular Matrix Remodelling in Obesity and Insulin ... https://www.researchgate.net/.../302971397_Adipose_Extracellular_Matrix_Remodellin... The extracellular matrix (ECM) of adipose tissues undergoes constant remodelling to allow adipocytes and their precursor cells to change cell shape and ... [PDF]Adipose extracellular matrix remodelling in obesity and insulin ... iranarze.ir/wp-content/uploads/2016/10/E457.pdf Please cite this article in press as: D. Lin et al., Adipose extracellular matrix remodelling in obesity and insulin resistance, Biochem. Pharmacol. (2016),. The emerging role of skeletal muscle extracellular matrix remodelling ... onlinelibrary.wiley.com/doi/10.1111/obr.12548/full?scrollTo=references May 5, 2017 - The extracellular matrix and insulin resistance. Trends Endocrinol Metab ... Adipose tissue remodeling and obesity. J Clin Invest 2011; 121: ... Aberrant Epicardial Adipose Tissue Extracellular Matrix Remodeling in ... https://www.nature.com › Scientific Reports › Articles Mar 3, 2017 - Aberrant Epicardial Adipose Tissue Extracellular Matrix Remodeling in ..... insulin resistance), was a hallmark of WAT enlargement in obesity. Increased IL-32 Levels in Obesity Promote Adipose Tissue ... - Diabetes diabetes.diabetesjournals.org/content/early/2016/09/12/db16-0287 by V Catalán - 2016 - Cited by 2 - Related articles Sep 2, 2016 - ... Promote Adipose Tissue Inflammation and Extracellular Matrix Remodeling. ... are associated with insulin resistance in human obesity. AMPK Activation by Metformin Suppresses Abnormal Extracellular ... diabetes.diabetesjournals.org/content/65/8/2295 by T Luo - 2016 - Cited by 13 - Related articles TGF-β1-induced insulin resistance is suppressed by AMPK agonists and the ... Physiologically, extracellular matrix (ECM) components such as collagens and ... However, how persistent aberrant ECM remodeling is initiated by obesity remains ... The Extracellular Matrix Protein MAGP1 Is a Key Regulator ... - Diabetes diabetes.diabetesjournals.org/content/63/6/1858 by MC Levin - 2014 - Cited by 4 - Related articles Components of the ECM include structural proteins, such as collagen and fibrillins, and ... In obesity, it is believed that altered expression of ECM components may ... of insulin resistance, suggesting that MFAP5 is related to ECM remodeling ...
