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عنوان فارسی مقاله:
بیوسنتز 4-استیل آنتراکوئینول B در قارچ آترود یا سینا مومیا از طریق گذرگاه مربوط به سنتز Q کوآنزیم
عنوان انگلیسی مقاله:
Biosynthesis of 4-acetylantroquinonol B in Antrodia cinnamomea via a pathway related to coenzyme Q synthesis
سال انتشار : 2017
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مقدمه انگلیسی مقاله:
1. Introduction
Antrodia cinnamomea is a well-known medicinal fungus often produced commercially by submerged fermentation in Taiwan. This fungus is known for its potent anti-hepatocellular carcinoma function. In a previous study, the key anti-hepatic compound from themyceliumofA. cinnamomea, 4-acetylantroquinonolB(4-AAQB), was isolatedandidentified. This compoundcaninhibitproliferation of hepatocellular carcinoma cells HepG2 with an IC50 of 0.1 g/mL [1].Whenthe HepG2 cells were treated with4-acetylantroquinonol B, CDK2 and CDK4 decreased and p27 increased in a dosedependent manner [2]. The treatment also increased the levels of p53 and p21 proteins. A previous study found that in the biosynthesis of 4-acetylantroquinonol B [3], based on the biosynthesis pathway of coenzyme Q,the benzoquinone ring might be produced from shikimic acid via the shikimate pathway and that the polyisoprenoid side chain may be produced from farnesyl diphosphate via the mevalonate pathway. Furthermore,the structure of 4-AAQB is very similar to that of coenzyme Q, so we suspected that the biosynthesis pathway of 4-AAQB was closely related to Coenzyme Q. Previous reports have discussed the biosynthesis of coenzyme Q. For Saccharomyces cerevisiae, the benzoquinone ring is formedfrom 4-hydroxybenzoic acid (4-HBA), which can be synthesized from chorismate via the shikimate pathway [4]. In E. coli, the aromatic ring also comes from 4-HBA, and nine enzymes involved in modification of the ring [5]. Recent research on the overproduction of coenzyme Q10 in microorganisms has been extensive [6]. Throughout the pathway, the exogenous addition of correct precursors to the medium, and overexpression of various enzyme genes are strategies for improving the yield of coenzyme Q10. We proposed that in A. cinnamomea, 4-AAQB was synthesized via the biosynthesis pathway of CoQ, after which CoQ would be converted to 4-AAQB. Various precursors of CoQ were tested in this study in order to construct the possible biosynthesis pathway of 4AAQB in A. cinnamomea (Fig. 1)
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کلمات کلیدی:
Biosynthesis in Antrodia Cinnamomea - NCBI - NIH https://www.ncbi.nlm.nih.gov/labs/articles/28001060/ Dec 21, 2016 - ... 4-Acetylantroquinonol B via a Polyketide Pathway Using Orsellinic ... cinnamomea, have a similar chemical backbone to coenzyme Q (CoQ). Coenzyme Q0 from Antrodia cinnamomea in Submerged ... - NCBI https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241310/ by CH Chung - 2014 - Cited by 6 - Related articles Nov 6, 2014 - We investigated the anticancer effects of Antrodia cinnamomea, ... Lung cancer is the leading cause of cancer-related morbidity in many countries [19]. Thus ..... (SKOV-3) cells via modulation of HER-2/neu signaling pathway. Biosynthesis of Antroquinonol and 4-Acetylantroquinonol B via a ... pubs.acs.org/doi/abs/10.1021/acs.jafc.6b04346 by KCC Chou - 2016 - Related articles Dec 6, 2016 - Biosynthesis of antroquinonol and 4-acetylantroquinonol B via polyketide pathway using orsellinic acid as a ring precursor in Antrodia cinnamomea ... cinnamomea, have similar chemical backbone to that of coenzyme Q ... Biosynthesis of Antroquinonol and 4-Acetylantroquinonol B via a ... pubs.acs.org/doi/full/10.1021/acs.jafc.6b04346 by KCC Chou - 2016 - Related articles Dec 6, 2016 - ... Using Orsellinic Acid as a Ring Precursor in Antrodia cinnamomea ... ring is formed through the shikimate pathway, such as coenzyme Q (from ... be closely related to the biosynthesis of CoQ via the shikimate pathway in A. Coenzyme Q0 from Antrodia cinnamomea in Submerged ... - Hindawi https://www.hindawi.com/journals/ecam/2014/246748/citations/ Sep 16, 2014 - Coenzyme Q0 from Antrodia cinnamomea in Submerged Cultures Induces ... B in Antrodia cinnamomea via a pathway related to coenzyme Q ... Genomic and transcriptomic analyses of the medicinal fungus Antrodia ... www.pnas.org/content/111/44/E4743.full.pdf by MYJ Lu - 2014 - Cited by 19 - Related articles Oct 21, 2014 - Antrodia cinnamomea, a polyporus mushroom of Taiwan, has long been used as a remedy ... an annual market of over $100 million (US) in Taiwan. ..... tional gene IDs in the P450-related pathways of “metabolism of xenobiotics ... involved in the biosynthesis of coenzyme Q10 for ubiquinone bioproduction,.
