دانلود رایگان مقاله لاتین فیبر عضلانی اسکلتی از سایت الزویر
عنوان فارسی مقاله:
مطالعه ساختاری فیبرهای عضلانی اسکلتی در سلامت و pseudomyotonia
عنوان انگلیسی مقاله:
Structural study of skeletal muscle fibres in healthy and pseudomyotonia affected cattle
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
The bovine “congenital pseudomyotonia” (PMT) is a muscular disorder clinically characterized by stiffness and progressive impairment of muscle relaxation induced by intense exercise (Testoni et al., 2008). Recently PMT was depicted as the true and unique animal model, although unconventional, of human Brody disease (Brody, 1969). Muscle contractures occur when animals are forced to move fast or are exposed to transport stress. If the exercise is prolonged, the contracture hampers the movement and affected animals consequently fall down. After a few seconds of rest, the stiffness disappears and the animals regain the ability to get up and move. Up to now, PMT pathological condition has been reported in Chianina (Testoni et al., 2008), in Romagnola (Murgiano et al., 2012) italian breeds and as a single case in a Dutch improved Red and White cross-breed calf (Grünberg et al., 2010) . Cattle PMT is an inherited recessive autosomal disorder, due to a sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) deficiency, resulting from a defect of ATP2A1 gene, coding for SERCA1 isoform (Drögemüller et al., 2008). In mammals, three genes encode three main SERCA isoforms which are expressed in striated muscles in a tissue-dependent fashion and according to the stage of development (Periasamy and Kalyanasundaram, 2007; Vangheluwe et al., 2009). SERCA1 isoform is expressed in adult fast-twitch type II skeletal muscle fibres. The SERCA2a variant is selectively expressed in slow-twitch type I skeletal muscle fibres and in the heart. SERCA is the main intrinsic protein component of nonjunctional sarcoplasmic reticulum (SR) membranes (Fleischer and Inui, 1989). It consists of three cytoplasmic domains, called Nucleotide-binding (N) Phosphorylation (P) and Actuator (A) domains, 10 transmembrane helices (M domain) and small SR luminal loops (Toyoshima et al., 2000).
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کلمات کلیدی:
PRIME PubMed | Pseudomyotonia in Romagnola cattle caused by ... www.unboundmedicine.com/.../Pseudomyotonia_in_Romagnola_cattle_caused_by_n... Bovine congenital pseudomyotonia (PMT) is an impairment of muscle ... We obtained four PMT affected Romagnola cattle and noted striking clinical ... Structural study of skeletal muscle fibres in healthy and pseudomyotonia affected cattle. Structural study of skeletal muscle fibres in healthy and ... - infona.pl https://www.infona.pl/resource/bwmeta1.element.elsevier-259b8e65.../collections Structural study of skeletal muscle fibres in healthy and pseudomyotonia affected cattle. Francesco Mascarello, Roberta Sacchetto · Details · Contributors · Fields ... manuscript revised www.jbc.org/content/early/2014/10/06/jbc.M114.576157.full.pdf by E Bianchini - 2014 - Cited by 5 - Related articles Oct 6, 2014 - Skeletal muscles of affected cattle are ... fibers from a biopsy from a pseudomyotonia affected .... from healthy Chianina cattle euthanized at. Pseudomyotonia in Romagnola cattle caused by novel ... https://bmcvetres.biomedcentral.com/articles/10.1186/1746-6148-8-186 by L Murgiano - 2012 - Cited by 6 - Related articles Oct 9, 2012 - Bovine congenital pseudomyotonia (PMT) is an impairment of muscle relaxation ... In muscular dystonia type II affected Belgian Blue cattle, Charlier et al. ... In case 3 the cryostat sections showed enlarged fibers with pale cytoplasm (Figure 1A) and .... Healthy animals carrying the ATP2A1 exon 8 variants (c. Pseudomyotonia disease: Malacards - Research Articles, Symptoms ... www.malacards.org/card/pseudomyotonia An important gene associated with Pseudomyotonia is ATP2A1 (ATPase ... study of skeletal muscle fibres in healthy and pseudomyotonia affected cattle.
