دانلود رایگان مقاله لاتین فقدان سازش تمامیت الیاف الاستیک از سایت الزویر
عنوان فارسی مقاله:
فقدان سازش تمامیت الیاف الاستیک تابع شریان کاروتید مشترک: مفاهیمی برای پیری عروقی
عنوان انگلیسی مقاله:
Loss of elastic fiber integrity compromises common carotid artery function: Implications for vascular aging
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
The mechanical functionality, structural integrity, and adaptive capacity of central arteries result in large part from cellular regulation of the myriad structural constituents that constitute the wall, and their interactions. Notwithstanding the many contributors to the mechanics of the arterial wall, four are of primary importance: elastic fibers, fibrillar collagens, contractile smooth muscle, and proteoglycans/glycosaminoglycans.1,2 Of these four, elastic fibers are unique - they alone do not turnover during maturity and they are not effectively repaired or replaced during disease or injury. That is, functional elastic fibers are produced prior to adulthood and they have a half-life on the order of 25e70 years in both mice and humans under normal conditions.3e6 These fibers are thus uniquely susceptible to damage by mechanical fatigue in addition to normal degradation by proteolysis.7e9 Because elastic fi- bers cannot be effectively repaired or replaced, congenital and acquired losses of elastic fiber integrity have irreversible consequences on arterial mechanics and mechanobiology, and thus the physiology and pathophysiology. Genetically induced changes in, proteolytic degradation of, or mechanical damage to elastic fibers contribute, therefore, to central artery stiffening in aging and hypertension, which in turn promote diverse cardiovascular, renovascular, and neurovascular diseases.10e12 Indeed, loss of elastic fiber integrity also plays direct mechanical roles in atherosclerosis, aneurysms, and dissections.13e15 Elastic fibers in central arteries are organized into concentric fenestrated elastic sheets, or laminae, that form a three-dimensional network in the media. These fi- bers consist primarily of a core of elastin (90%) plus multiple elastin-associated glycoproteins.2,16 The glycoproteins fibulin-5 and fibrillin-1 are fundamental to the elastogenesis and long term mechanical and biological stability, respectively, of the composite fibers.17,18 Elastic fibers also associate with proteoglycans and minor collagens (e.g., collagen VIII), though specific contributions of these constituents to mechanical functionality is less clear.16 Nevertheless, loss of elastic fiber integrity has five primary consequences to the arterial wall: loss of resilience and thus a decrease in elastic recoil,19 decrease in collagen fiber undulation and thus diminished distensibility and extensibility,20 loss of cellematrix interactions and thus altered smooth muscle cell phenotypic activity,17,21 increased intramural inflammation due to the chemotactic character of elastin degradation products,9 and possible premature entrance into the cell death cycle, or anoikis.22 Among the many important consequences of reduced elastic fiber integrity, we focused on the mechanical functionality of the common carotid artery (CCA) in the mouse. Specifically, we contrasted passive biaxial mechanical behaviors of carotids from control, elastin haploinsufficient (Elnþ/), fibrillin-1 deficient (Fbn1mgR/mgR), and fibulin-5 null (Fbln5/) mice with elastase-treated carotids from control mice. In this way, we assessed graded effects on wall structure and function due to elastic fibers ranging from normal to fully compromised. New biaxial data (Elnþ/) are presented and compared with previously published data (controls from,23 elastasetreated and Fbn1mgR/mgR from,20 and Fbln5/ from 24) using new approaches for interpreting the data. By treating control and elastase-treated data as upper and lower bounds of elastic fiber functionality, respectively, we elucidated graded changes in carotid artery mechanics across the three genetic models. Importantly, total elastic energy displays a strong qualitative correlation with the severity of elastic fiber disarray. Meth
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کلمات کلیدی:
Elastin Haploinsufficiency Induces Alternative Aging Processes in the ... online.liebertpub.com/doi/abs/10.1089/rej.2007.0587 by M Pezet - 2008 - Cited by 63 - Related articles Jan 3, 2008 - With aging, elastin is progressively degraded, leading to arterial ... Loss of elastic fiber integrity compromises common carotid artery function: ... Jacopo Ferruzzi - Google Scholar Citations scholar.google.com/citations?user=ykYPgDwAAAAJ&hl=en PhD Student, Yale University - yale.edu Biomechanical phenotyping of central arteries in health and disease: advantages of ... Loss of elastic fiber integrity compromises common carotid artery function: ... JCI - Citations to Developmental adaptation of the mouse ... https://www.jci.org/articles/view/19028/citations Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in ... Loss of elastic fiber integrity compromises common carotid artery function: ... FastRef | FastFormat https://fastformat.co/b/fastref?q=author:'M.R.%20Bersi' - Translate this page [Artigo] Loss of Elastic Fiber Integrity Compromises Common Carotid Artery Function: Implications for Vascular Aging · J. Ferruzzi; M.R. Bersi; R.P. Mecham; ... Assembly of Lung Elastin - Robert Mecham - Grantome grantome.com/grant/NIH/R01-HL053325-21 When elastin is not expressed because of loss of function mutations, the lung does .... (2016) Loss of Elastic Fiber Integrity Compromises Common Carotid Artery ...
