دانلود رایگان مقاله لاتین فعالیت ضد ویروسی بتا کربولین از سایت الزویر
عنوان فارسی مقاله:
فعالیت ضد ویروسی بتا-کربولین طبیعی و مصنوعی ضد ویروس دانگ
عنوان انگلیسی مقاله:
Antiviral activity of natural and synthetic b-carbolines against dengue virus
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Dengue, a mosquito-borne viral infection that prevails in tropical and subtropical regions of the world, is caused by any of the four dengue virus serotypes (DENV 1e4). Dengue is endemic in more than 100 countries and its incidence has increased 30-fold in the past 50 years (Guzman and Harris, 2015; Simmons et al., 2015). DENV infection presents a wide spectrum of manifestations including asymptomatic condition, dengue fever, or severe forms, such as dengue hemorrhagic fever and dengue shock syndrome (John et al., 2015). There is a need for an effective dengue therapeutic that can prevent the development of severe complications and reduce on-going transmission of the virus to mosquitoes and new human hosts. Although several compounds that target virus or host components are in development, only a few agents have been assessed in formal clinical trials and unfortunately the assayed compounds showed no benefit in preventing the outcome of severe forms of the disease or in reducing plasma viremia (Castilla et al., 2015; Whitehorn et al., 2014). The use of natural sources is a well-established strategy to obtain new substances with potential therapeutic activity (Cao et al., 2007; Khan et al., 2013). Among alkaloids, b-carbolines (aromatic structures with three 6-5-6-fused rings) are known to present diverse biological properties. For example, harmine and harmane, which constitute between 2 and 6% of Peganum harmala seeds, have a wide range of therapeutic applications (Moloudizargari et al., 2013; Nenaah, 2010; Patel et al., 2012). Previous studies performed with natural and synthetic b-carbolines have shown that these compounds display antiviral activity against herpes simplex virus (HSV), poliovirus (PV) and human immunodeficiency virus (Bag et al., 2014; Brahmbhatt et al., 2010; Chen et al., 2015; Nazari Formagio et al., 2009; Wang et al., 2007). The antiviral activity of other structurally related alkaloids against viruses with DNA and RNA genome has also been reported (Ashok et al., 2015; Liu et al., 2014; Sako et al., 2008; Salim et al., 2010; Song et al., 2014; van Maarseveen et al., 1999). Particularly, g-car- * Corresponding author. bolines have been proved to be highly potent inhibitors of bovine viral diarrhea virus (BVDV), a bovine pathogen that belongs to the Flaviviridae family (Sako et al., 2008, Salim et al., 2010). Here we evaluated the antiviral activity of natural and synthetic b-carbolines against DENV and the mode of antiviral action of the active compound 9N-methylharmine was investigated.
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کلمات کلیدی:
Recent Advances of Natural and Synthetic β-Carbolines as Anticancer ... https://www.researchgate.net/.../268879894_Recent_Advances_of_Natural_and_Synthet... Oct 15, 2016 - Recent Advances of Natural and Synthetic β-Carbolines as Anticancer ... A Potent Derivative of Indolizino[6,7-b]Indole for Treatment of Human ... Recent Advances of Natural and Synthetic β-Carbolines as Anticancer ... https://www.readbyqxmd.com/.../recent-advances-of-natural-and-synthetic-î-carboline... In this review, we cover recent natural and synthetic β - carbolines with anticancer activity ... Structural features controlling the binding of beta-carbolines to the ... Naturally occurring and synthetic Beta-carbolines as cholinesterase ... agris.fao.org/agris-search/search.do?recordID=US201302287585 by S Ghosal - 1972 - Cited by 19 - Related articles Naturally occurring and synthetic Beta-carbolines as cholinesterase inhibitors [1972]. Ghosal, S. Bhattacharya, S.K. Mehta, R. Naturally occurring and synthetic ... [PDF]Synthesis and Fungicidal Activity of β-Carboline Alkaloids and Their ... www.mdpi.com/1420-3049/20/8/13941/pdf by Z Li - 2015 - Cited by 2 - Related articles Jul 31, 2015 - β-carboline alkaloids are a large group of natural and synthetic indole alkaloids that ... tricyclic pyrido[3,4-b]indole ring structure (Figure 1) [1–3]. Progress in Heterocyclic Chemistry https://books.google.com/books?isbn=0080553087 Gordon W. Gribble, J. Joule - 2007 - Science A few intriguing developments in the area of tetrahydro-B-carboline synthetic ... as synthetic targets as well as key intermediates in natural product synthesis. The Total Synthesis of Natural Products https://books.google.com/books?isbn=0470129522 John ApSimon - 2009 - Science Since the B-carboline nucleus 1 forms a portion of the skeleton of (I) (2) many indole alkaloids, a great deal of effort has been expended into synthetic ... [PDF]Antiviral activity of natural and synthetic β-carbolines against ... iranarze.ir/wp-content/uploads/2016/10/E1092.pdf Aug 24, 2016 - We determined that the natural b-carboline harmol and a synthetic ... Previous studies performed with natural and synthetic b-carbolines. Facile Synthesis of 1,2,3,4-Tetrahydro-β-carbolines by One-Pot ... pubs.acs.org/doi/abs/10.1021/ol900460m by Y Ohta - 2009 - Cited by 46 - Related articles Apr 8, 2009 - Two direct synthetic methods of 1,2,3,4-tetrahydro-β-carboline derivatives have ... The Journal of Organic Chemistry 2017 82 (5), 2364-2374.
