دانلود رایگان مقاله لاتین فسفولیپاز d2 در بیماری از سایت الزویر
عنوان فارسی مقاله:
تراکم بینش به نقش فسفولیپاز D2 در بیماری های انسان
عنوان انگلیسی مقاله:
Accumulating insights into the role of phospholipase D2 in human diseases
سال انتشار : 2015
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مقدمه انگلیسی مقاله:
1. Introduction
Phospholipase D2 (PLD2) is a member of PLD family that catalyzes the hydrolysis of phosphatidylcholine (PC) to yield free choline and phosphatidic acid (PA), a lipid signaling molecule (Jenkins and Frohman, 2005; Tu-Sekine et al., 2015). PLD2 has several domains that are conserved among members of the PLD family (Frohman et al., 1999). PA generation is catalyzed by the HKD domain (HKD, contains the HxKxxxxD motif). The Phox homology (PX) domain and pleckstrin homology (PH) domain are important for interactions with phospholipids and other proteins that facilitate specific PLD2 functions (Exton, 2002; Jang et al., 2012; Lopez et al., 1998; Oude Weernink et al., 2007). Recently, the guanine nucleotide exchange factor (GEF) activity of the PH domain was also reported, expanding the potential areas for PLD2 function (Jeon et al., 2011; Lee et al., 2006). In several signaling pathways, PLD-generating PA and PLD itself play critical roles in mediating and coordinating signals. Based on the signaling functions, PLD2 activated in response to various stimuli have been known to contribute to a number of cellular functions, such as growth, proliferation, differentiation, migration, vesicle trafficking, and cytoskeleton remodeling (Cazzolli et al., 2006; Lee et al., 2009). The versatile properties of PLD2 have allowed the prediction of possible roles in pathophysiology in vivo. However, definitive in vivo functions of PLD2 have only recently begun to be demonstrated (Frohman, 2015; Tappia and Dhalla, 2014). Here, we summarize the accumulated direct evidence for the pathophysiological roles of PLD2 from genetically engineered animal models. Future directions for study are also briefly discussed.
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کلمات کلیدی:
Accumulating insights into the role of phospholipase D2 in human ... https://www.researchgate.net/.../285673892_Accumulating_insights_into_the_role_of_p... Official Full-Text Publication: Accumulating insights into the role of phospholipase D2 in human diseases on ResearchGate, the professional network for ... [PDF]Accumulating insights into the role of phospholipase D2 in human ... iranarze.ir/wp-content/uploads/2016/10/E112.pdf Accumulating insights into the role of phospholipase D2 in ... Phospholipase D2 (PLD2) is a lipid-signaling enzyme that produces the signaling molecule. Phospholipases in Health and Disease https://books.google.com/books?isbn=1493904647 Paramjit S. Tappia, Naranjan S. Dhalla - 2014 - Science Du G, Huang P, Liang BT, Frohman MA (2004) Phospholipase D2 localizes to ... al (2008) A role for phosphatidic acid in COPI vesicle fission yields insights into ... The Role of Phospholipase D in Signaling Cascades - Plant Physiology www.plantphysiol.org/content/120/3/645.full by X Wang - 1999 - Cited by 127 - Related articles The genetic manipulation of PLD in the cell was achieved in plants, mammals, and yeast, and this has provided new insights into the involvement of PLD in ... Handbook of Cell Signaling - Page 1174 - Google Books Result https://books.google.com/books?isbn=0080920918 Ralph A. Bradshaw, Edward A. Dennis - 2009 - Science COPI vesicle fission: a role for phosphatidic acid and insight into Golgi maintenance. ... Phospholipase D2 localizes to the plasma membrane and regulates ... Transduction Mechanisms in Cellular Signaling: Cell Signaling Collection https://books.google.com/books?isbn=0123838630 Edward A. Dennis, Ralph A. Bradshaw - 2011 - Science COPI vesicle fission: a role for phosphatidic acid and insight into Golgi maintenance. ... Phospholipase D2 localizes to the plasma membrane and regulates ... Molecular Mechanisms of Exocytosis - Page 82 - Google Books Result https://books.google.com/books?isbn=0387399615 Romano Regazzi - 2008 - Science Shen Y, Xu L, Foster D. Role for phospholipase D in receptor-mediated endocytosis. ... in adrenal chromaffin cells: Insights into NSF/SNAP/SNARE function. [PDF]Insights into the Molecular Mechanisms of Phospholipase D-Mediated ... etd.library.vanderbilt.edu/available/etd-01142014-193543/unrestricted/bruntz.pdf Insights into the Molecular Mechanisms of Phospholipase D-Mediated ...... to function as an inhibitor of endogenous PLD activity (Steed et al., 1998). Likewise,.
