دانلود رایگان مقاله لاتین غنی سازی مولفه تیونینگ از سایت الزویر
عنوان فارسی مقاله:
غنی سازی مولفه تیونینگ در اسید آمینه عاملدار شده
عنوان انگلیسی مقاله:
Tuning component enrichment in amino acid functionalized (organo)silicas
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Since the development of mesoporous silica materials, such as the MCM and SBA families [1,2], research on these materials has ever been increasing. They are characterized by large pore sizes, i.e., between 2 and 50 nm and large surface areas, often exceeding 1000 m2 /g. Moreover, the functionality of silica materials can easily be manipulated by incorporation of active sites in the walls (co-condensation) or by anchoring active species on the surface (post-functionalization). As a result, mesoporous silica materials exhibit promising performances in many applications including adsorption [3,4], chromatography [5,6], electronics [7,8], drug delivery [9,10] and catalysis [11,12]. In the framework of catalysis, an interesting research field is situated in the use of aminated silica materials to catalyze carbon-carbon coupling reactions [13–22]. These reactions are widely used in the pharmaceutical industry and fine chemicals production [23]. Moreover, a bright future in the valorization of biomass-based resources has been forecasted for these reactions [24,25]. However, mesoporous silica materials exhibit a limited hydrothermal stability, which is often related to the hydrolysis of SiO-Si bonds [26,27]. Hence, the water tolerance of these materials should be enhanced in order to further broaden their scope of application. In 1999, three research groups, independent from one another, incorporated organic groups in the pore walls through the condensation of bridged organobissilanes, with the general formula (R′O)3-Si-R-Si- (OR′)3, in the presence of a surfactant [28–30]. The presence of the organic moieties specifically results in periodic mesoporous organosilicas (PMOs), which have a more hydrophobic character compared to the original silica materials. It turns the PMOs into materials which are comparatively more robust in an aqueous environment [31]. Originally, only a limited number of organobissilanes (methane, ethane, ethene and benzene bissilanes) were used. Nowadays, a wide variety is available, providing opportunities to tune the hydrophobicity of the organosilica materials. Moreover, these organobissilanes allow the incorporation of a more extended range of functional groups in the materials, either by the direct introduction via the organobissilanes or by the post-modification of the organic moieties incorporated in the pore walls [32]. In this work, the wide variety of organo(bis)silanes is used to probe the selective enrichment of reactant molecules in amino acid functionalized catalysts and, consequently, optimize the catalytic performance in different environments. A catalyst library comprising different cysteine functionalized materials is prepared and the effect of the incorporation of different organic moieties is investigated in the aldol reaction of acetone with 4-nitrobenzaldehyde. Additionally, the ability of the materials to cope with traces of water in the reaction mixture is studied.
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کلمات کلیدی:
Highly Specific Enrichment of Glycopeptides Using Boronic Acid ... pubs.acs.org/doi/pdf/10.1021/ac801912t by Y Xu - 2008 - Cited by 210 - Related articles Dec 8, 2008 - A novel boronic acid functionalized mesoporous silica, which holds the ... tides, which contain several hydrophilic amino acids, reveal as. Specific Enrichment of Phosphoproteins Using Functionalized ... pubs.acs.org/doi/abs/10.1021/ja511833y by L Hwang - 2015 - Cited by 17 - Related articles Feb 5, 2015 - Analysis of protein phosphorylation remains a significant challenge due to the low abundance of phosphoproteins and the low stoichiometry of ... Sparrho | Tuning component enrichment in amino acid functionalized (o https://www.sparrho.com/item/tuning...enrichment-in-amino-acid-functionalized.../9c7d... Tuning component enrichment in amino acid functionalized (organo)silicas. Imported: 10 Oct '16 | Published: 06 Oct '16. Jeroen Lauwaert, Judith Ouwehand, ... Essential Amino Acids—Advances in Research and Application: 2012 Edition https://books.google.com/books?isbn=1464994439 2012 - Medical “The extreme complexity of protein samples is becoming a great challenge for ... a new method using hydrazide-functionalized magnetic microspheres was ... can be selectively and sensitively enriched from complex and low-volume samples. Highly specific enrichment of glycopeptides using boronic acid ... - NCBI https://www.ncbi.nlm.nih.gov/pubmed/19117470 by Y Xu - 2009 - Cited by 209 - Related articles Jan 1, 2009 - A novel boronic acid functionalized mesoporous silica, which holds the attractive ... high surface area and large accessible porosity, was developed to enrich glycopeptides. ... Amino Acid Sequence; Boronic Acids/chemistry* ... Amine-functionalized TiO₂ nanoparticles for highly selective - NCBI https://www.ncbi.nlm.nih.gov/pubmed/26078180 by H Liu - 2015 - Cited by 4 - Related articles May 16, 2015 - Specific enrichment of trace phosphoproteins or phosphopeptides from ... was investigated by the standard protein digests and human serum.
