دانلود رایگان مقاله لاتین سیگنال دهی گیرنده آدنوزین درونی از سایت الزویر
عنوان فارسی مقاله:
گرفتن شخصی: سیگنال دهی گیرنده های آدنوزین درونی در رده های سلولی لیمفوبلاست
عنوان انگلیسی مقاله:
Getting personal: Endogenous adenosine receptor signaling in lymphoblastoid cell lines
سال انتشار : 2016
برای دانلود رایگان مقاله سیگنال دهی گیرنده آدنوزین درونی اینجا کلیک نمایید.
مقدمه انگلیسی مقاله:
1. Introduction
The majority of therapeutic drug targets to date are within the G protein-coupled receptor (GPCR) superfamily, a class of membrane-bound proteins [1,2]. As such, GPCRs have been widely and intensively studied for the development of new therapeutics. Among the most well-studied members of this group are the adenosine receptors, a family comprising of 4 different subtypes: A1, A2A, A2B and A3 [3]. The various subtypes have been implied in a broad range of diseases and (patho)-physiological conditions, such as a variety of respiratory and inflammatory conditions for the A2A or cardiovascular disorders for the A1 [4]. Likewise, a wide variety of compounds selectively activating, inhibiting or modulating these receptors are available to date [3,4]. Some of these have even been or are currently in clinical trials [3,4]. Adenosine itself has been long approved for treatment of supraventricular tachycardia [3] and one A2AR antagonist, istradefylline, has made it to the market as adjuvant drug therapy for Parkinson’s disease in Japan [5]. In the emerging era of personalized medicine, it is paramount for drug development to better understand the effects of a drug not only in the overall population, but in the individual patient as well [6]. Genetic differences between individuals can affect drug action. Accordingly, several examples linking GPCR polymorphisms to diseases and drug response variation already exist [7–11], which include many commonly targeted GPCRs [11] such as purinergic [12,13], cannabinoid [9,10] and adenosine [14–16] receptors. Specifically for the adenosine A2A receptor, Single Nucleotide Polymorphisms (SNPs) have been associated with for instance anxiety [17,18], caffeine intake [17], or vigilance and sleep [14]. Despite these examples of statistical association of genotype and condition, as well as extensive mutational characterization of the adenosine receptors, little is known about the direct functional effect of receptor polymorphisms or SNPs. Therefore, an ideal set-up would be to use patient-derived material as a model system to study the influence of polymorphisms on receptor response.
برای دانلود رایگان مقاله سیگنال دهی گیرنده آدنوزین درونی اینجا کلیک نمایید.
کلمات کلیدی:
Getting personal: Endogenous adenosine receptor signaling in ... www.sciencedirect.com/science/article/pii/S0006295216301320 by JM Hillger - 2016 - Cited by 2 - Related articles Sep 1, 2016 - As a showcase we studied adenosine A2A receptor (A2AR) signaling in lymphoblastoid cell lines (LCLs) derived from a family of four from the ... Getting personal: Endogenous adenosine receptor signaling in ... https://www.researchgate.net/.../303983776_Getting_personal_Endogenous_adenosine_... Jan 25, 2017 - Getting personal: Endogenous adenosine receptor signaling in Lymphoblastoid Cell Lines on ResearchGate, the professional network for ... Getting personal: Endogenous adenosine receptor signaling in ... isi-dl.com/item/93813 Getting personal: Endogenous adenosine receptor signaling in lymphoblastoid cell lines. sciencedirect.com. Source Link ... [PDF]Getting personal: Endogenous adenosine receptor signaling in ... iranarze.ir/wp-content/uploads/2016/10/E2317.pdf Jun 11, 2016 - adenosine A2A receptor (A2AR) signaling in lymphoblastoid cell lines ... LCL, lymphoblastoid cell line; NTR, Netherlands Twin Register; PBS, ... Adenosine and adenosine receptors in the pathogenesis and ... - Nature www.nature.com/nrrheum/journal/v13/n1/abs/nrrheum.2016.178.html by BN Cronstein - 2017 - Cited by 2 - Related articles Nov 10, 2016 - The expression and function of adenosine receptors on different cell types ...... adenosine receptor signaling in lymphoblastoid cell lines. Hydrogen Sulfide in Redox Biology https://books.google.com/books?isbn=0128016221 2015 - Science the induction by CoCl2 of intranuclear NF-κB p65 subunit and cellular HIF1α ... in CEM cells but decreased adenosine deaminase activity, adenosine receptor ... of T lymphocytes induces the T cell antigen receptor (TCR) signaling cascade that ... Human B lymphoblastoid cell lines grew in cystine-deficient medium, but T ... Human lymphoblastoid cell line panels: novel tools for assessing ... www.futuremedicine.com › Journal home › TOC by A Morag - 2010 - Cited by 28 - Related articles (2016) Getting personal: Endogenous adenosine receptor signaling in lymphoblastoid cell lines. Biochemical Pharmacology 115, 114-122. Online publication ... Adenosine and Adenine Nucleotides As Regulators of Cellular Function https://books.google.com/books?isbn=0849369282 John W. Phillis - 1991 - Science ... and lymphocyte cell lines secrete adenosine deaminase, Adv. Exp. Med. ... ribonucleotides and deoxyribonucleotides in human T lymphoblastoid cells, ... and intracellular formaton of adenosine, in Purines in Cellular Signaling. ... Marone, G., Vigorita, S., Triggiani, M., and Condorelli, M., Adenosine receptors on human ... External Article Page - Faculty of 1000 f1000.com/prime/ext/726422893 Jun 11, 2016 - As a showcase we studied adenosine A2A receptor (A2AR) signaling in lymphoblastoid cell lines (LCLs) derived from a family of four from the ...
