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عنوان فارسی مقاله:
تعامل بین سیستم های سروتونین و کانابینوئید هیپوکامپ در واکنش پذیری به تشخیص تازگی شی و اسپاتیال
عنوان انگلیسی مقاله:
Interaction between hippocampal serotonin and cannabinoid systems in reactivity to spatial and object novelty detection
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Among the numerous serotonin (5-HT) receptors, the 5-HT4 receptors, appear to be of particular importance in cognitive processes [1–3]. High density of 5-HT4 receptors in the limbic sys tem, mainly on the pyramidal neurons of hippocampus, suggests a potential role in learning and memory [4,5]. These receptors belong to the superfamily of G-protein coupled receptors which are positively coupled to adenylate cyclase (AC) [6] leading to the intracellular accumulation of cAMP. This increase of cAMP observed after the application of 5-HT4 agonists contributes to the neuronal excitability of pyramidal cells of hippocampus by inhibiting potassium channels [7,8]. Behavioral studies have shown that 5- HT4 selective agonists improve social learning in rats [9], enhance accuracy performances in delayed matching tasks in macaques [10] and enhance place and object recognition in young adult rats [11]. Indeed, a pro-cognitive effectfor 5-HT4 receptor agonists in several phases of memory has been confirmed [12].
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کلمات کلیدی:
Frontiers | Role of the Endogenous Cannabinoid System in Nicotine ... journal.frontiersin.org/article/10.3389/fpsyt.2015.00041/full by IH Gamaleddin - 2015 - Cited by 15 - Related articles Mar 6, 2015 - Recently, other components of the endogenous cannabinoid system have ... using reverse transcription polymerase chain reaction (RT-PCR) (24). ..... of nicotinic acetylcholine receptors on hippocampal serotonin release. [PDF]Involvement of the CA1 GABAA receptors in ACPA-induced ... www.iricss.org/fa/Documents/Articles-91-92/92-18.pdf by B Yousefi - 2013 - Cited by 26 - Related articles Rationale: Cannabinoids are shown to modulate the hippocampal memory processing ...... ters (Sullivan, 1999) including serotonin (Molina-Holgado, Amaro, ... dopaminergic system in reactivity to spatial and non-spatial changes in mice. Anandamide - Page 304 - Google Books Result https://books.google.com/books?isbn=0080887899 2009 - Science Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus. Nat. ... (2008). The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system. ... Cyclooxygenase-2 does not contribute to postischemic production of reactive oxygen species. [PDF]Cannabinoids and prefrontal cortical function: Insights from preclinical ... www.cogsci.ucsd.edu/~pineda/.../marijuana/Cannabinoids%20and%20PFCtx.pdf by A Egerton - 2006 - Cited by 131 - Related articles 686. 4.1. Dopamine, GABA and glutamate . .... role for the endocannabinoid system in regulating dopamine .... hippocampal rather than prefrontal cortical function (for review, see .... recently confirmed using the rat lateralized reaction time task. Lifestyle Medicine, Second Edition - Page 1419 - Google Books Result https://books.google.com/books?isbn=1439845441 James M. Rippe - 2013 - Medical Exercise activates the endocannabinoid system. ... is required for voluntary exercise-induced enhancement of progenitor cell proliferation in the hippocampus. Sexdependent longterm effects of adolescent exposure to THC and/or ... onlinelibrary.wiley.com/doi/10.1111/bph.12519/pdf by AB Lopez‐Rodriguez - 2014 - Cited by 16 - Related articles Nov 13, 2013 - effects of THC and/or MDMA on glial reactivity and on serotoninergic and cannabinoid systems were assessed by ... expression and functionality of hippocampal CB1 receptors. (Mateos ... gesting that the cannabinoid system may play a role in the ... glial (astrocytes and microglia) cells and on the serotonin. Cannabinoid–serotonin interactions in alcohol ... - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2006.04054.x/pdf by S Kelaï - 2006 - Cited by 33 - Related articles Because cannabinoid and serotonin (5-HT) systems have been proposed to ... phosphate-c-S binding in the hippocampus of both mouse strains. Conversely ...... differences in reactivity to cannabinoid receptor ligands for both ethanol intake ...
