دانلود رایگان مقاله لاتین رسوراترول به عنوان القاء هموگلوبین جنینی از سایت الزویر
عنوان فارسی مقاله:
بررسی رسوراترول و آنالوگ به عنوان القاء بالقوه هموگلوبین جنینی
عنوان انگلیسی مقاله:
The investigation of resveratrol and analogs as potential inducers of fetal hemoglobin
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Βeta-thalassemia, a global health burden, is an inherited disorder of beta globin chain production. The disease is characterized by reduced synthesis of functional β-globin chains, leading to imbalanced globin chain ratio, ineffective erythropoiesis and anemia [1]. As a result, thalassaemic patients require regular blood transfusions with regular iron chelation therapy as a means of managing the disease. However, this treatment is not curative and still has substantial morbidity. A very promising therapeutic approach for β-thalassemia is the production of fetal hemoglobin (HbF) through pharmacological reactivation of endogenous gamma-globin genes as γ-globin can substitute for the absent or reduced adult β-globin [2,3]. The currently available HbFinducing chemical agents have limited clinical application due to their moderate therapeutic properties and potential cytotoxic effects [4,5]. Therefore, identification of novel agents with higher HbF inducing activity and lower cytotoxicity has been one of the major challenges over the past few years. Oxidative stress has been observed in various types of thalassemia as well as in other hereditary and acquired hemolytic anemias. This can be mainly attributed to iron overload due to increased iron absorption in the gastrointestinal tract [6], multiple blood transfusions as well as to increased intracellular denaturation of imbalanced hemoglobin subunits resulting in dissociation of heme from globin and iron from heme [7,8]. Labile non-transferrin bound iron can be involved in chemical reactions that generate reactive oxygen species (ROS) that affect various cellular components, particularly the cell membrane, damaging vital organs including the heart, liver and endocrine system [9]. In addition, endogenous antioxidant mechanisms are depleted due to the increased need to neutralize the oxidative stress [10]. Oral administration of vitamin E in transfusion-independent beta-thalassemia patients was shown to decrease ROS production and increase glutathione reductase levels in red blood cells [11]. Moreover, natural antioxidants such as curcuminoids [12] and fermented papaya preparation [13] were studied for their potential use towards elimination of antioxidant stress.
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کلمات کلیدی:
FK228 Analogues Induce Fetal Hemoglobin in Human Erythroid ... https://www.hindawi.com/journals/anemia/2012/428137/ by L Makala - 2012 - Cited by 2 - Related articles Mar 7, 2012 - Fetal hemoglobin (HbF) improves the clinical severity of sickle cell ..... been used to screen pharmacological agents as potential HbF inducers. [PDF]Medicinal Chemistry of Fetal Hemoglobin Inducers for Treatment of ... www.unife.it/comunicazione/servizi/Vetrina_ricerca/RG-All1.pdf by R Gambari - 2007 - Cited by 75 - Related articles Keywords: Fetal hemoglobin; β-thalassemia; Histone deacethylases; Hydroxyurea; DNA-binding drugs; Rapamycin. This paper is .... OF POTENTIAL INDUCERS OF FETAL HEMO- ..... patients, but clinical development of these analogs was. The investigation of resveratrol and analogs as potential inducers of ... https://www.deepdyve.com/.../the-investigation-of-resveratrol-and-analogs-as-potential-i... Read "The investigation of resveratrol and analogs as potential inducers of fetal hemoglobin" on DeepDyve - Instant access to the journals you need! The investigation of resveratrol and analogs as potential inducers of ... iranarze.ir/wp-content/uploads/2016/10/E2347.pdf Dec 1, 2015 - The investigation of resveratrol and analogs as potential inducers of fetal hemoglobin. Andria Theodorou a,b, Marios Phylactides a,⁎, Luca ... A reduced curcuminoid analog as a novel inducer of fetal hemoglobin ... link.springer.com/10.1007/s00277-012-1604-1 by N Chaneiam - 2013 - Cited by 6 - Related articles Oct 19, 2012 - A reduced curcuminoid analog as a novel inducer of fetal hemoglobin ... especially bisdemethoxycurcumin are potential γ-globin enhancers. Wintrobe's Clinical Hematology - Page 897 - Google Books Result https://books.google.com/books?isbn=1469846225 John P. Greer, Daniel A. Arber, Bertil Glader - 2013 - Medical Butyrate and its analogs, including short-chain fatty acid derivatives, have been used ... In general, the small-scale studies of the induction of fetal hemoglobin in ... of the disease.770 Moreover, there are concerns about the potential for serious ... Hemoglobins—Advances in Research and Application: 2013 Edition: ... https://books.google.com/books?isbn=1481688642 2013 - Medical For more information on this research see: Antisickling fetal hemoglobin reduces ... Linkoping. University. Hospital: A. potential. role. of. fetal. hemoglobin. in. the ... nucleoside analog (NA) 9-betaD-arabinofuranosylguanine (AraG) revealed a ... induce global DNA demethylation and induction of Hb gamma and P-gp both at ... Wintrobe's Clinical Hematology https://books.google.com/books?isbn=0781765072 John P. Greer - 2009 - Medical 5-Azacytidine is a cytidine analog that, when incorporated into newly synthesized ... In general, the small-scale studies of the induction of fetal hemoglobin in ... are concerns about the potential for serious side effects from the longterm use of ... Induction of fetal hemoglobin expression by the ... - Blood Journal www.bloodjournal.org/content/101/5/2001.full.pdf by O Witt - 2003 - Cited by 112 - Related articles Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin ... Among these compounds, butyrate analogues have been studied over many years ..... as described. Figure 1 shows that the HbF-inducing potential of the.
