دانلود رایگان مقاله لاتین دیسپرسیو از سایت الزویر
عنوان فارسی مقاله:
ارتقای دیسپرسیو جامد آمورف مبتنی بر سلولز جدید برای غلظت محلول کورستین در شرایط این ویترو
عنوان انگلیسی مقاله:
Novel cellulose-based amorphous solid dispersions enhance quercetin solution concentrations
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Q (Fig. 1) is a dietary flavonol (a subclass of flavonoids) present at high levels in foods including apples, onions, and broccoli (Caridi et al., 2007; Price, Casuscelli, Colquhoun, & Rhodes, 1998). Q intake has been associated with many potential health benefits, including reduced risk of cardiovascular disease (Russo, Spagnuolo, Tedesco, Bilotto, & Russo, 2012), cancer (Firdous et al., 2014; Jaganathan, 2011; Zhou et al., 2010), and diabetes and obesity (Chis¸ , Baltaru,Maier, Mures¸ an, & Clichici, 2013; Gutierrez, Prater, & Holladay, 2014; Song, 2005). Poor Q oral bioavailability severely limits its potential to bene- fit health. This low bioavailability is largely due to its crystallinity, and hence poor solubility (ranging from 2.15 to 7.7 g/mL at 25 ◦C (Lauro et al., 2002; Srinivas, King, Howard, & Monrad, 2010)) in the aqueous milieu of the gut lumen, as well as extensive metabolism and subsequent luminal efflux by gut epithelial cells (Phase-II and Phase-III xenobiotic metabolism, respectively). Improved Q solubility may increase bioavailability by increasing the amount available for absorption, and by saturating Phase-II and Phase-III metabolic enzymes; both effects are likely to result in increased net flux into circulation. Many techniques have been employed to improve Q oral bioavailability, such as protein- or cellulose-based nanoparticles (Fang et al., 2011; Kakran, Sahoo, Li, & Judeh, 2012; Sahu, Saraf, Kaur, & Saraf, 2013), encapsulation (Dian et al., 2014), nanoemulsih
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کلمات کلیدی:
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