دانلود رایگان مقاله لاتین درمان بازگردش استخوانی پایین از سایت الزویر
عنوان فارسی مقاله:
دام درمان بازگردش استخوانی پایین: اثر بر تخلخل قشری مغز
عنوان انگلیسی مقاله:
The pitfall of treating low bone turnover: Effects on cortical porosity
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
It is well recognized that chronic kidney disease (CKD) patients are exposed to a high risk of fracture. Fractures are indeed associated with significantly higher morbidity and mortality in these patients than in the general population [1,2]. Compromised bone strength leading to fracture may be associated to changes in both trabecular and cortical bone compartments. Although it is well recognized that cortical bone contributes significantly to the mechanical strength of the skeleton, little is known about this compartment from bone biopsy studies. Recently, it has been described that an increase in cortical porosity (Ct.Po) is a common finding in CKD, especially in non-white patients [3]. Moreover, a prospective study using high-resolution peripheral quantitative computed tomography has shown that CKD patients may experience deterioration in cortical bone over time [4]. Mineral bone disease (MBD) therapy is usually applied to control levels of phosphate, calcium and parathyroid hormone (PTH), including phosphate binders, calcitriol as well as adjustments in calcium dialysate concentration. However, there is paucity of data regarding the effects of such therapy on Ct.Po. Therefore, we have aimed to evaluate the effects of one-year CKD-MBD therapy on Ct.Po in patients on conventional hemodialysis.
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