دانلود رایگان مقاله لاتین حساسیت عاج دندان با استرانسیم از سایت الزویر
عنوان فارسی مقاله:
استرانسیم حاوی، شبکه های مبتنی بر پلیمر کربوهیدرات به عنوان سیستم های دندان به هم چسبیده برای درمان حساسیت شدید عاج دندان
عنوان انگلیسی مقاله:
Strontium-containing, carbohydrate-based polymer networks as tooth-adherent systems for the treatment of dentine hypersensitivity
سال انتشار : 2016
برای دانلود رایگان مقاله حساسیت عاج دندان با استرانسیم اینجا کلیک نمایید.
مقدمه انگلیسی مقاله:
1. Introduction
Hypersensitivity or dentine sensitivity may be defined as an exaggerated response to a non-noxious stimulus (thermal, chemical, tactile or osmotic), due principally to exposure of the dentine to the oral environment (Bamise & Esan, 2011; Mantzourani & Sharma, 2013; West, Seong, & Davies, 2015). Typically, the loss of enamel and/or the covering of periodontal tissues as a consequence of chipped teeth, fractured restorations, restorative treatments and dental caries have been reported to induce dentine sensitivity (Addy, 1990). There are a limited number of reports detailing the incidence of dentine sensitivity, due at least in part to the lack of routine screening for this clinical problem by dentists (unless prompted to do so by patients) (Mantzourani & Sharma, 2013). As a result, reports of the prevalence of dentine sensitivity vary considerably. For example, Addy (Addy, 1990) reported that the condition occurred in 8–30% of the adult dentate population whereas Chabanski et al. reported a prevalence of dentine sensitivity of 84%, with no identified bias towards gender (Chabanski, Gillam, Bulman, &The most widely accepted theory to explain the mechanism of dentine hypersensitivity involves the transmission of pain producing stimuli to the pulp by rapid movement of the fluid in the dentinal tubules (hydrodynamics) (Bamise & Esan, 2011; Mantzourani & Sharma, 2013). Exposure of external stimuli may cause expansion or contraction of the fluid contained within the capillaries of the dentine. (Absi, Addy, & Adams, 1987). Treatment of dentine sensitivity typically involves the topical application of a desensitising agent which ideally should be non-irritant to the pulp, painless on application, easy to apply, non-staining and consistently effective for prolonged periods of time (Chabanski et al., 1996; Mantzourani & Sharma, 2013; West et al., 2015). The treatments of dentine sensitivity include the use of chemical agents, notably strontium chloride, calcium hydroxide and silver nitrate (Bamise & Esan, 2011; Curtis, West, & Su, 2010; Rosenthal, 1990; Wang et al., 2010), which aim to block the dentinal tubules, thereby reducing the movement of dentinal fluid. Whilst this may be performed by the application of a film-forming lacquer (applied by a dental practitioner), application by the patient is preferred, normally using toothpastes and gels. Clinically, the efficacy of strontium chloride has been shown in a series of studies (Arnold, Prange, & Naumova, 2015; Blitzer, 1967; Seong et al., 2013; Shapiro, Kaslick, & Chasens, 1970; Shapiro, Kaslick, Chasens, & Weinstei, 1970; West et al., 2013, 2015), however, recently, ameta analyses reported by Bae et al. questioned the efficacy of strontium-containing toothpastes (Bae, Kim, & Myung, 2015). It is proposed however that this reflects, at least in part, differences in the formulation platforms used in these clinical studies and reveals one potential area of weakness, namely the formulation of platforms that optimise the delivery of chemical agent (e.g. strontium) to the affected tooth and hence enhance clinical efficacy. Akin to drug delivery platforms designed for the treatment of local disorders (Jones, Irwin, Woolfson, Djokic, & Adams, 1999; Jones, Woolfson, Brown, Coulter, McClelland, & Irwin, 2000), the clinical efficacy of platforms designed for the prevention/treatment of dentine hypersensitivity is dependent on the retention of the platform at the tooth surface (Martens & Surmont, 1991). Mucoadhesive topically applied platforms may be useful in that they maintain the formulation at the applied site for longer periods of time. To date, mucoadhesive platforms have not been specifically designed for application to the tooth surface for the prevention/treatment of hypersensitivity. Therefore, given this scenario, this study specifically describes a bioactive, mucoadhesive platform that is designed for the prevention/treatment of dentine hypersensitivity. In particular, this study describes the design and characterisation of carbohydrate-based platforms in which, by manipulation of the concentrations and ratios within the binary/ternary polymer platforms, compositions may be produced that offer wide ranges of mechanical, viscoelastic, flow, mucoadhesion and strontium release properties that are relevant to this clinical application. Key to performance of these platforms is the use of two cellulose polymers, hydroxyethylcellulose and sodium carboxymethylcellulose. This study additionally seeks to utilise the interaction between strontium ions and the polymeric matrix to design platforms with unique and clinically appropriate physicochemical properties.Inadditionto the aforementioned,this study is unique in the comprehensive nature of the characterisation of such systems, the latter using a wide range of analytical techniques that provide information directly relevant to the clinical performance of the platforms. As such the authors believe that this study will conceptually redefine the design and characterisation of platforms for application to the tooth surface
برای دانلود رایگان مقاله حساسیت عاج دندان با استرانسیم اینجا کلیک نمایید.
کلمات کلیدی:
Strontium-containing, carbohydrate-based polymer networks as tooth ... https://www.sparrho.com/.../strontium-containing-carbohydrate-based-polymer-network... Oct 9, 2016 - Publication date: 10 February 2017 Source:Carbohydrate Polymers, Volume 157 ... Strontium-containing, carbohydrate-based polymer networks as tooth-adherent systems for the treatment of dentine hypersensitivity. PRIME PubMed | hypersensitive tooth journal articles from PubMed www.unboundmedicine.com/medline/research/hypersensitive_tooth Strontium-containing, carbohydrate-based polymer networks as tooth-adherent systems for the treatment of dentine hypersensitivity. [Journal Article] ... PRIME PubMed | Metastron journal articles from PubMed https://www.unboundmedicine.com/medline/research/Metastron ... effective on sensitive skin. Strontium-containing, carbohydrate-based polymer networks as tooth-adherent systems for the treatment of dentine hypersensitivity. PRIME PubMed | polycarbophil journal articles from PubMed https://www.unboundmedicine.com/medline/research/polycarbophil Development and characterization of mucoadhesive buccal gels containing lipid nanoparticles of ibuprofen. ... Lobo JMS; The lipid nanoparticles, namely Nanostructured Lipid Carriers (NLC), as drug delivery systems have .... Strontium-containing, carbohydrate-based polymer networks as tooth-adherent systems for the ... Andrews G[au] - PubMed Result www.cmaj.ca/external-ref?access_num=Andrews%20G&link_type... Strontium-containing, carbohydrate-based polymer networks as tooth-adherent systems for the treatment of dentine hypersensitivity. Carbohydr Polym. 2017 Feb ...
