دانلود رایگان مقاله لاتین حساسیت درد زای ستاستیلاسیون هیستون از سایت الزویر
عنوان فارسی مقاله:
TBI ناشی از حساسیت درد زای ستاستیلاسیون هیستون
عنوان انگلیسی مقاله:
TBI-induced nociceptive sensitization is regulated by histone acetylation
سال انتشار : 2017
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مقدمه انگلیسی مقاله:
1. Introduction
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide, affecting all ages and demographics (Hyder et al., 2007). In the United States alone, approximately 1.7 million new cases are reported annually (Coronado et al., 2011; Faul and Coronado, 2015). While the vast majority of these injuries are mild, even these have been associated with a number of adverse consequences. These include memory impairment, anxiety, depression and other changes with variable patterns of onset and persistence (Murphy and Carmine, 2012; Rao et al., 2015). One of the most common complaints of patients after TBI is, however, chronic pain; it has been estimated that more than 50% of TBI patients develop chronic pain at some point after their injuries (Nampiaparampil, 2008). TBI was observed to confer an odds ratio of 5.0 for chronic pain in a recently described military cohort (Higgins et al., 2014). Unlike some of the more severe motor and cognitive consequences, chronic pain after TBI appears to be at least as likely to be experienced by those with mild as opposed to severe injuries (Nampiaparampil, 2008). While the overall prevalence of chronic pain after TBI is high, the anatomical distribution of those symptoms is very broad. The mostcommonly reported painful areas include the head, spine, limbs, and chest; amongst those with pain, limb pain is experienced by more than one-third of TBI patients (Mittenberg et al., 1992; Lahz and Bryant, 1996). Moreover, greater than 80% of polytrauma patients suffering from both TBI and peripheral injury report ongoing pain (Sayer et al., 2009). Relatedly, TBI worsens the functional outcomes of injuries to the extremities (Andruszkow et al., 2013). Although only limited experimentation has been conducted, we are beginning to define the interactions of TBI with pain signaling pathways using laboratory models. For example, reduced periorbital and forepaw mechanical nociceptive thresholds were observed in both rats and mice using the Controlled Cortical Impact (CCI) model of TBI (Macolino et al., 2014). Recently Mustafa et al. used a closed-head TBI model in rats to demonstrate that multiple centers in the trigeminal sensory system (TSS) showed changes in the expression of pain-related genes. Correlations between changes in NK1 receptor expression and 5-HT fiber density with facial nociceptive sensitization were noted (Mustafa et al., 2016). An additional report from our laboratory showed hindpaw sensitization in rats after TBI using the Lateral Fluid Percussion (LFP) model as well as changes in spinal levels of brain derived neurotrophic factor (BDNF), a pain signaling related neurotrophin (Feliciano et al., 2014). The involvement of BDNF is particularly interesting in that the spinal expression of this gene is strongly regulated to control pain sensitivity after limb injury and chronic opioid exposure (Li et al., 2008; Liang et al., 2014). The mechanism for upregulation of spinal BDNF expression in these settings appears to involve the epigenetic acetylation of histone protein at the H3K9 mark leading to enhanced gene transcription. More broadly, epigenetic changes in the setting of TBI were recently reviewed with the conclusion that they likely participate in modulating multiple long-term consequences of TBI (Wong and Langley, 2016). To begin our studies we characterized TBI-induced bleeding and blood-brain barrier breakdown after lateral fluid percussion (LFP) injury. We went on to examine the hypothesis that test agents able to block histone acetylation would reduce the severity and duration of nociceptive sensitization after TBI and that histone deacetylase inhibitors would have opposite effects. Further, we expected to observe that animals with dual TBI and hindpaw injuries, a model of polytrauma, might also respond to inhibitors of histone acetylation.
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کلمات کلیدی:
Chronic Pain in Neurotrauma - Brain Neurotrauma - NCBI Bookshelf https://www.ncbi.nlm.nih.gov › NCBI › Literature › Bookshelf by RA Moshourab - 2015 - Cited by 1 - Related articles Traumatic brain injury (TBI) and spinal cord injury (SCI) impose a high personal, social, .... Evoked pain can either be induced by a noxious (hyperalgesia) or ..... In conclusion, altered input from sensitized trigeminal nociceptors coupled with ... Nociceptive sensitization and BDNF up-regulation in a rat ... - NCBI https://www.ncbi.nlm.nih.gov/pubmed/25246352 by DP Feliciano - 2014 - Cited by 11 - Related articles Sep 20, 2014 - Nociceptive sensitization and BDNF up-regulation in a rat model of ... Our findings suggest that TBI-induced up-regulation of spinal BDNF ... Nociceptive Neuropeptide Increases and Periorbital Allodynia in a ... https://www.ncbi.nlm.nih.gov › NCBI › Literature › PubMed Central (PMC) by MB Elliott - 2012 - Cited by 23 - Related articles May 8, 2012 - TBI was induced using an electromagnetic stereotaxic impactor ..... nociceptive pathway, and in turn induce central sensitization and elicit ... TBI-induced nociceptive sensitization is regulated by histone ... - ISI-dl isi-dl.com/item/301591 ... thieme-connect.com, wiley.com, worldscientific.com. SEARCH. TBI-induced nociceptive sensitization is regulated by histone acetylation. sciencedirect.com ... Recent IBRO Reports Articles - Elsevier https://www.journals.elsevier.com/ibro-reports/recent-articles Feb 24, 2017 - TBI-induced nociceptive sensitization is regulated by histone acetylation ... Chronic pain after traumatic brain injury (TBI) is very common, but ... Nociceptive sensitization and BDNF up-regulation in ... - Academia.edu www.academia.edu/.../Nociceptive_sensitization_and_BDNF_up-regulation_in_a_rat_... Our findings suggest that TBI-induced up-regulation of spinal Traumatic brain injury Chronic pain BDNF levels might contribute to chronic TBI-related pain, and ... IBRO | IBRO Reports, Open Access Journal ibro.info/news/ibro-reports-open-access-journal/ Jan 24, 2017 - Our findings demonstrate that TBI induces sustained nociceptive sensitization, and changes in spinal neuronal histone proteins may play an ...
