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عنوان فارسی مقاله:
حذف مشروط IGF-I در استخوان به طور غیر منتظره ای پیوند استخوانی شکاف شکستگی در موش را تسریع میبخشد
عنوان انگلیسی مقاله:
Conditional deletion of IGF-I in osteocytes unexpectedly accelerates bony union of the fracture gap in mice
سال انتشار : 2016
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مقدمه انگلیسی مقاله:
1. Introduction
Bone has an amazing ability to regenerate itself without a scar after injuries, such as fractures. The repair of long bone fractures is mediated by endochondral bone repair, which is divided into four major overlapping stages: 1) the initial inflammatory response, 2) the formation of soft callus, 3) the formation of hard callus, and 4) the bone remodeling and bony union of the fracture gap [1]. The remodeling phase involves resorption of cartilage and conversion of the cancellous callus bone into cortical bone that is indistinguishable from native bone. This phase also includes neovascularization to re-establish blood flow to the fracture site [2]. The mechanism responsible for fracture repair is highly complex and involves actions of the various cell types (including osteoblasts, osteoclasts, chondrocytes, osteocytes, endothelial cells, and mesenchymal stem cells) through local expression of the variety of growth factors and signaling molecules that lead to coordinated development of cartilaginous callus, bony remodeling of the callus, bony union of the gap, and the eventual restoration of the bone structure and strength. The osteocyte, which is the most abundant cell type in the cortical bone, has an extensive network of dendrites extending to and making contact with other osteocytes, periosteal and endosteal lining cells, bone surface osteoblasts and osteoclasts, and bone marrow cells through a widespread, interconnected canaliculi system [3]. This network of canaliculi allows soluble osteocyte-derived paracrine signaling molecules to migrate freely from the osteocyte to act on other bone cells [4]. Hence, the osteocyte is strategically well positioned within the bone matrix to sense physical and biochemical signals that regulate bone metabolism, remodeling, and local regeneration. There is now increasing evidence that the osteocyte and its secretory factors, such as sclerostin (Sost), may play key regulatory roles in fracture repair. For instance, earlier studies have suggested that surviving osteocytes at fracture sites are important for robust cellular recruitment of the various cell types and the release of osteopontin during the initial phase of fracture healing [5] and that osteocytes participate in the periosteal callus cartilage formation and bone regeneration during fracture healing [6]. More recent studies have shown that during hip fracture healing, the expression of Sost by osteocytes at the fracture site was downregulated [7]. Mice lacking the Sost gene accelerated fracture healing [8,9]
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کلمات کلیدی:
Conditional deletion of IGF-I in osteocytes unexpectedly ... - Bone www.thebonejournal.com/article/S8756-3282(16)30216-2/abstract by KHW Lau - 2016 - Cited by 1 - Related articles •Osteocyte Igf1 cKO mice formed smaller calluses with less cartilage but more bony tissue than wild-type littermates. •Conditional deletion of Igf1 in osteocytes ... [PDF]Supplemental Information to Conditional Deletion of IGF-I in ... https://www.researchgate.net/profile/K_H_Lau/.../Supplemental-Information.pdf Conditional Deletion of IGF-I in Osteocytes Unexpectedly Accelerates Bony Union of the Fracture. Gap in Mice. K.-H. William Lau1,2, Charles H. Rundle2, ... Osteoporosis - Page 536 - Google Books Result https://books.google.com/books?isbn=0080553478 Robert Marcus, David Feldman, Dorothy Nelson - 2007 - Medical The IGF-II receptor is the same as the mannose-6-phosphate receptor, does not ... on the role of IGF-I during development, and conditional gene deletions have ... Conditional Deletion of Insulin-like Growth Factor-I ... - Cancer Research cancerres.aacrjournals.org/content/canres/68/9/3495.full.pdf by BW Sutherland - 2008 - Cited by 63 - Related articles Figure 1. Conditional deletion of IGF-IR in prostate epithelial cells causes proliferation. A, left, immunohistochemical analysis with anti-Cre antibody to show how. Insulin-like Growth Factor Signaling During Myogenesis https://books.google.com/books?isbn=1109113293 Hongxia Ren - 2009 IGFBP-5 mutant resistant to proteolysis should not potentiate IGF-II actions, and rather ... Conditional deletion of IGF-IR in adipose tissue leads to significantly ... The Growth Hormone/Insulin-Like Growth Factor Axis during Development https://books.google.com/books?isbn=0387262741 Isabel Varela-Nieto, Julie Ann Chowen - 2005 - Medical Recently, several types of conditional IGF-IR receptor knockouts have been ... deletion (MeuCre) with mice bearing the floxed IGF-H2 allele, conditional mutants ... Conditional Deletion of Insulin-Like Growth Factor-I in Collagen Type ... press.endocrine.org/doi/pdf/10.1210/en.2007-0608 by KE Govoni - 2007 - Cited by 82 - Related articles To determine the role of local IGF-I, type 1α2 collagen-Cre mice were crossed with IGF-I loxP mice to generate Cre+ (conditional mutant) and Cre− (control) loxP ... Non-Coding RNAs: Molecular Biology and Molecular Medicine https://books.google.com/books?isbn=0306478358 Jan Barciszewski - 2003 - Science Deletions ofH19 Sequence at the Endogenous Locus Mutation of the DMD at the ... to activation of this normally silent allele.42,43 Conditional deletion of the DMD ... Conversely, maternal inheritance of a DMD deletion activates the silent Igfi ...
