دانلود رایگان مقاله لاتین توزیع کیتوزان هیدروکسی پروپیل از سایت الزویر
عنوان فارسی مقاله:
جذب و توزیع کیتوزان هیدروکسی پروپیل محلول آب در موش ها پس از تجویز خوراکی
عنوان انگلیسی مقاله:
Absorption and distribution of water-soluble hydroxypropyl chitosan in mice after oral administration
سال انتشار : 2016
برای دانلود رایگان مقاله توزیع کیتوزان هیدروکسی پروپیل اینجا کلیک نمایید.
مقدمه انگلیسی مقاله:
1. Introduction
As a natural linear cationic polysaccharide, chitosan (CS) has attracted much scientific and industrial interest in the fields of biotechnology, pharmaceutics, food science, waste water treatment, agricultures and textiles (Elchinger et al., 2015; MatiBaouche et al., 2014; Ravi Kumar, Muzzarelli, Muzzarelli, Sashiwa, & Domb, 2004; Sandford & Stinnes, 1991; Shahidi, Arachchi, & Jeon, 1999), due to its unique bioactivity, including its excellent biodegradability, biocompatibility and nontoxicity (McAlindon, LaValley, Gulin, & Felson, 2000; Muzzarelli, 1993; Peng, Han, Liu, & Xu, 2005). In 1983, CS has been approved as feed additive by Food and Drug Administration (FDA). Especially for the pharmaceutical and biomedicine area, most studies indicated that CS has been considered as one of the most excellent candidates for drug delivery systems to enhance drug absorption, control drug release and target therapy as drug carriers (Agnihotri, Mallikarjuna, & Aminabhavi, 2004; Bansal, Sharma, Sharma, Pal, & Malviya, 2011; Bernkop-Schnürch & Dünnhaupt, 2012; Ravi Kumar et al., 2004; Sonia & Sharma, 2011; Wang, Tao, Zhang, Wei, & Ren, 2010). Although many studies have been focused on the applications of CS in food engineering and biomedicine, its bioactive properties in vivo remained unclear, including bio-distribution, body absorption, biodegradation and toxicity, which were in close relation with drug action, medicine persistence and safety. Chae et al. investigated molecular-weight-dependent body absorption of CS in vitro and in vivo. CS oligosaccharides showed higher permeation and absorption profiles with negligible cytotoxic effect, which may be considered as a safe and potential candidate for pharmaceutical and biomedical applications (Chae, Jang, & Nah, 2005). Onishi et al. discovered that chitin with 50% deacetylate was highly biodegradable and was excreted quickly, and there was no accumulation in the mice after intraperitoneal administration (Onishi & Machida, 1999). As for CS micro-particles, Shimoda et al. analyzed its bioadhesive and absorptive characteristics (Shimoda, Onishi, & Machida, 2001; Takishima, Onishi, & Machida, 2002). Our previous study also found that the body absorption of CS was in close relation with its molecular weight and water-solubility (Zeng, Qin, Wang, Chi, & Li, 2008). CS with lower molecular weight had bettersolubility and was absorbed more easily by body tissues. For the absorption and distribution of chitosan, it was difficult for chitosan to be located in vivo, due to its colorless and no UV absorption, and so it was necessary for chitosan to be labeled using fluorescein. At present, isothiocyanate was used as fluorescein most commonly in most past studies (Chae et al., 2005; Onishi & Machida, 1999; Shimoda et al., 2001; Zeng et al., 2008). In spite of these superior properties, plain CS has a major drawback: its solubility is poor above pH 6.0 (Qin et al., 2006). Now that most researches indicated that the bioactivity of CS was in close relation with its molecular weight and solubility, it is necessary to investigate the bioactivity of the water-soluble CS, such as carboxymethyl CS, and CS quaternary ammonium salt. Hydroxypropyl CS (HPCS) is another CS derivative with excellent water solubility, which was potentially suitable for drug carrier and food additive (Bansal et al., 2011; Sonia & Sharma, 2011; Wang et al., 2010). In the past few years, the structure, properties and use of HPCS were studied (Dong, Wu, Wang, & Wang, 2001; Peng et al., 2005), but little research about its metabolism in vivo was done. The safety evaluation of modified natural products is very important for their applications in food and drug carrier. In this paper, HPCS with different molecular weights was used to investigate its absorption and distribution in mice after oral administration by using fluorescein-labeling method.
برای دانلود رایگان مقاله توزیع کیتوزان هیدروکسی پروپیل اینجا کلیک نمایید.
کلمات کلیدی:
Porous quaternized chitosan nanoparticles containing paclitaxel ... https://www.ncbi.nlm.nih.gov/pubmed/22044456 by PP Lv - 2011 - Cited by 59 - Related articles Nov 10, 2011 - Porous quaternized chitosan nanoparticles containing paclitaxel nanocrystals improved therapeutic efficacy in non-small-cell lung cancer after oral administration. ... Mice; Mice, Inbred C57BL; Nanoparticles/administration & dosage ... Drug Carriers; N-(2-hydroxypropyl)-3-trimethylammonium chitosan ... The current view on biological potency of cationically modified chitosan. https://www.ncbi.nlm.nih.gov/pubmed/24930505 by J Stefan - 2014 - Cited by 13 - Related articles The current view on biological potency of cationically modified chitosan. ... N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC) that was ... 1 hour after oral administration as found in C57BL/6j mice using FITC-labeled polymer. [PDF]Design of Chitosan and Its Water Soluble Derivatives-Based Drug ... www.mdpi.com/1660-3397/12/12/6236/pdf by QX Wu - 2014 - Cited by 10 - Related articles Dec 19, 2014 - meaning that, after oral administration, the chitosan microspheres would remove H. .... chitosan must be coated with enteric coatings, like hydroxypropyl .... Y. Biodegradation and distribution of water-soluble chitosan in mice. Absorption and distribution of water-soluble hydroxypropyl chitosan in ... www.zoodyab.ir/.../60855-absorption-and-distribution-of-water-sol... - Translate this page Two kinds of water-soluble hydroxypropyl chitosan (HPCS) samples with different ... in mice by oral administration after being labeled by fluorescein isothiocyanate. ... After oral administration of HPCS, HPCS would undergo a series of ... Oral delivery of therapeutic proteins and peptides: a review on recent ... www.tandfonline.com/doi/full/10.3109/10717544.2013.819611 by S Gupta - 2013 - Cited by 63 - Related articles Jul 20, 2013 - On oral administration of chitosan-hydroxypropyl methylcellulose ... Their efficacies for oral delivery were evaluated before and after coating with chitosan .... microparticles when administered to fasted mice reduced the blood ... Polymeric Biomaterials, Revised and Expanded https://books.google.com/books?isbn=0203904672 Severian Dumitriu - 2001 - Technology & Engineering After intratumoral administration of 5 mg/kg of mitomycin C in the mice, the percentage ... C. Chitosan for Colon-Specific Drug Delivery Following oral administration, ... as ethyl cellulose (131), hydroxypropyl methylcellulose acetate succinates, ...
